UK - Warnings Over Fatal Ectasy Tablets In The South

Urinary retention can cause hyponatremia by not allowing the kidneys to rid the body of excess water. This leads to an electrolyte imbalance (dangerously low sodium levels in the blood) which - depending on the amount of excess water and sodium levels - can lead to coma and/or death.

MDMA (by an unknown mechanism) has been shown to cause vasopressin secretion, which is an antidiuretic hormone.[1] This by itself has caused fatal hyponatremia in users who drank too much water too quickly.[2]

Diphenhydramine inhibits parasympathetic nerve impulses by selectively blocking the binding of the neurotransmitter acetylcholine to its receptor in nerve cells. The nerve fibers of the parasympathetic system are responsible for the involuntary movement of smooth muscles present in the gastrointestinal tract, urinary tract, lungs, etc.[3] No more nerve impulses to the bladder means urinary retention. Diphenhydramine is strictly contraindicated in anyone with an enlarged prostate for this reason.

Usually you'd have to drink a lot of water and within a quick time period while on either MDMA or diphenhydramine for things to get serious. But combine the vasopressin secretion from the MDMA with a lack of nerve impulses to the bladder due to the diphenhydramine and the risk of developing hyponatremia is increased.

[1] http://www.ncbi.nlm.nih.gov/pubmed/16574714
[2] http://en.wikipedia.org/wiki/Leah_Betts
[3] http://en.wikipedia.org/wiki/Anticholinergic

Further Reading:

"Urinary retention: a cause of hyponatremia?" - http://www.ncbi.nlm.nih.gov/pubmed/17119339

Does Ecstasy by itself cause urinary retention, if somebody drinks way too much water while high on ecstasy?
 
Does Ecstasy by itself cause urinary retention, if somebody drinks way too much water while high on ecstasy?

Assuming it's actual MDMA, yes it does tend to, regardless of the amount of water someone drinks. That being said, it's not like it makes it impossible to take a piss. Just less frequent IME. However, if you're rolling and - for whatever reason - you decide to drink 10 bottles of water in the span of a couple of hours, you could end up in the hospital due to "water poisoning".
 
PMA + MDMA - PMA by itself is quite efficient at raising core body temperatures and heart-rate to dangerous levels. I say efficient because only a small dosage is required, and it happens virtually all the time. MDMA also slightly raises core body temperatures as well as HR, but by itself rarely to dangerous levels. Combine it with PMA however and the results are usually life threatening (if not fatal). Even when used alone, PMA can be extremely dangerous because its therapeutic dosage range is so thin.

MDMA + DXM - The combination may lead to serotonin syndrome, which is considered a medical emergency and can be fatal. Furthermore, DXM inhibits an enzyme in the liver (CYP2D6) which is used to break down and remove MDMA from the body. With the enzyme not being able to do its job (inhibited = switched off), MDMA levels in the body can increase to levels where its adverse effects may be cause for concern, particularly in those who like to chase the high by ingesting another dose a couple of hours later.

MDMA + Diphenhydramine - As a potent anticholinergic, diphenhydramine (among other things) can cause urinary retention. Therefore it's possible that combining with MDMA increases the risk of hyponatremia (water poisoning) as users typically drink water to alleviate dry mouth caused by the MDMA. Like DXM, diphenhydramine is also a CYP2D6 inhibitor.

MDMA + Methamphetamine - IME, this combo can lead to severe dehydration, bruxism (teeth grinding), hypertension, tachycardia, anxiety, paranoia, restlessness, and possible panic attacks in susceptible individuals. It may also increase any neurotoxicity caused by either the meth, or the mdma. Also, some people (at least one that I personally know of) began their meth habit after they bought and used a "meth bomb" (ecstasy pill with lots of methamphetamine, and little to no actual mdma) at a party.

MDMA + Ephedrine/Caffeine - Similar to MDMA + Methamphetamine, only milder in most cases. IME the risk of dehydration is actually worse when combining MDMA with ephedrine.

What about those people that got seizures or got put into comas from ecstasy? Was that caused by the ecstasy itself, or by the other substances that was laced with the ecstasy?
 
What about those people that got seizures or got put into comas from ecstasy? Was that caused by the ecstasy itself, or by the other substances that was laced with the ecstasy?

I dont even know why i bother explaining you something when you already now evertything, maybe because im fucked up right now and im in a good mood. Anyways ECSTASY is suposed to = MDMA or MDA, nothing else. For some people Methylone,MDEA can be acceptable though. BUt they are all MDXX. ANd most ofthe clean tabs and capsules are MDMA. Nowadays most of the E isnt MDMA,or isnt only MDMA. Anyways, ro4eva explained very clearly that its the COMBINATION that causes the symptoms. Like you just read what he wrote and its all there. Why do you ask things like that,when you know the answer? Troll us ? Because youre bored? Because you want to ask question and have no better idea?
 
Really? Mdma + pma for example can cause most of the time serotonin syndrome which is deadly. Mdma + Dxm can cause the same thing, resulting in death again if things go sour. Even if you dont die serotonin syndrome is no joke. There was a case recently in which a woman took E + coke + mephedrone and died, cardiac arrest i think. Mdma + amphetamine or Mdma + methamphetamine causes overheating and mroe dehyadration than mdma alone, i dont know about any deaths for that. Mdma + coke, while it is completly pointless because one blocks the other kinda, can be very dangerous heartwise. If some body takes MDMA onyl, the cances they have to die from it are almost non exsitant.

MDMA + methamphetamine is a classic and probably the original idea of lacing pills, back a decade ago when mdma was 50 dollars and "speed" was 20 dollars a pill, in eastern canada, at one point mdma lost popularity and the mix of the 2 was more popular because people would remain "tripping" after the mdma had worn off, while pure mdma pills meant 5 hours of partying max and the contraindications of alcohol being taken with it....while alcohol + meth (orally at least) has proven fine to me in the past due to it reducing heart rate/ aiding in chilling out.

It's all sad though, because since about after 2005, pure mdma pills are hard to come by, most often they are 2c-b or some mdmx + speed or just outright speed,but the amphetamine market has exploded and it has kinda been made obvious by now that white pills = meth/amphetamine....but then around 2009 there was a lot of fucking BZP/ pipes that would fizz on your tongue and that's about when I got out of the game.

The last great pills I got were rectangular white ICE pills, they were obviously meth + a little of mdmx...which seem to be what most people refer as good pills now..:p
 
MDMA + methamphetamine is a classic and probably the original idea of lacing pills, back a decade ago when mdma was 50 dollars and "speed" was 20 dollars a pill, in eastern canada, at one point mdma lost popularity and the mix of the 2 was more popular because people would remain "tripping" after the mdma had worn off, while pure mdma pills meant 5 hours of partying max and the contraindications of alcohol being taken with it....while alcohol + meth (orally at least) has proven fine to me in the past due to it reducing heart rate/ aiding in chilling out.

It's all sad though, because since about after 2005, pure mdma pills are hard to come by, most often they are 2c-b or some mdmx + speed or just outright speed,but the amphetamine market has exploded and it has kinda been made obvious by now that white pills = meth/amphetamine....but then around 2009 there was a lot of fucking BZP/ pipes that would fizz on your tongue and that's about when I got out of the game.

The last great pills I got were rectangular white ICE pills, they were obviously meth + a little of mdmx...which seem to be what most people refer as good pills now..:p

Yeah def alcohol while on ice made the mhigh more euphoric and a bit less tense and jittery. To be honest there wasnt a problem for me to eat some MDMA and to have a few light beers or soem chmpagne while rolling. But liquor....bleeeh. I noticed too, often, if id take E pills i would have a more energetic and speedy roll than molly caps. There are exception though. THe strongest pill i ever had, was orange, and like more little then your normal E. Id say either Mda or MDMA + MDA. But i droped two at once and had the impression i ate a truckload of mdma lol, i was floooooored. For hours. Like the first roll,even stronger, roliing on the floor mumbling all kinds of non sense. THose were limited sadly.

And yeah youe right man nowadays most of waht is suposed to be E is all kinds of shit. Everybody going crazy about the G pill, blue or orange,dependeing, oh its mdma and lsd bla bla bla everytime it was 2c-B. Halloween were 2c-E or I im not sure. Of course there is the LSD infused canadians, which are obviously some kind or rc (even though he say mdma and ketamin ive tried and a lot of my friends tough and its a strange high) http://www.pillreports.com/index.php?page=display_pill&id=18711. The dreaded diamonds, i had the pleasure of trying some of the first batchs, but this? http://www.pillreports.com/index.php?page=display_pill&id=25543 ? somebody pissed of the presser lol.

But yeah everybody in the pill scene knows white = speed. My favorite speed pills were the rectangular ICE. the Roman clocks (first batches), the white one with the joker imprinted on it (heavy), sonic, A1's. Are you really sure there is mdxx in ice? Because i only felt a strong meth high...no rolling feeling. WHat was your experience?
 
Damn man, you canadian too ? The best speedy "rolls", i think they had mdma in it due to massive feelsgoodman and augmentation of tactile pleasure but 2 years ago when I was still bothering with pills, the white roman clocks, the white rectangular ICE and the weird gears of war clock-piece shaped pills were the best shit, then I got these pieces of shit with a grenade and a small heart on top of the grenade which made me have huge terror-inducing ventricular asystoles made me just say fuck that shit, go to my doctor and tell him the truth "Alright, I give in, I need something for the ADD : PI that ruined a lot of my school years and work years, methylphenidate makes me have seizures (it did back when I was 17/18 and I never touched a ritalin pill after that, just 3 weeks of "treatment") so I was scripted Dexedrine, because that is paid for by gov insurance, while Adderall XR isn't and the government doctors at the ministry of health have to approve of your doctor's script and have forms filled yadayada same with Vyvanse....i know it doesn't make sense....Dex IR and Dex spansules (all brand name too, we dont have generics for it) are awwright with em. Probably some doctors up the chain really love their dexies....but I notice how these lack the mdmx or whatever there is that makes you want to fuck for 48 hours in these, maybe its just that meth is more sexual...adderall XR 25mg when I got it at first was also very pervy, lol, but it was too expensive for me to pay all for it, 135 dollars for 30 speed pills just isn't right with me.
 
Damn man, you canadian too ? The best speedy "rolls", i think they had mdma in it due to massive feelsgoodman and augmentation of tactile pleasure but 2 years ago when I was still bothering with pills, the white roman clocks, the white rectangular ICE and the weird gears of war clock-piece shaped pills were the best shit, then I got these pieces of shit with a grenade and a small heart on top of the grenade which made me have huge terror-inducing ventricular asystoles made me just say fuck that shit, go to my doctor and tell him the truth "Alright, I give in, I need something for the ADD : PI that ruined a lot of my school years and work years, methylphenidate makes me have seizures (it did back when I was 17/18 and I never touched a ritalin pill after that, just 3 weeks of "treatment") so I was scripted Dexedrine, because that is paid for by gov insurance, while Adderall XR isn't and the government doctors at the ministry of health have to approve of your doctor's script and have forms filled yadayada same with Vyvanse....i know it doesn't make sense....Dex IR and Dex spansules (all brand name too, we dont have generics for it) are awwright with em. Probably some doctors up the chain really love their dexies....but I notice how these lack the mdmx or whatever there is that makes you want to fuck for 48 hours in these, maybe its just that meth is more sexual...adderall XR 25mg when I got it at first was also very pervy, lol, but it was too expensive for me to pay all for it, 135 dollars for 30 speed pills just isn't right with me.

If you don't mind me asking, are you with Trillium?
 
Damn man, you canadian too ? The best speedy "rolls", i think they had mdma in it due to massive feelsgoodman and augmentation of tactile pleasure but 2 years ago when I was still bothering with pills, the white roman clocks, the white rectangular ICE and the weird gears of war clock-piece shaped pills were the best shit, then I got these pieces of shit with a grenade and a small heart on top of the grenade which made me have huge terror-inducing ventricular asystoles made me just say fuck that shit, go to my doctor and tell him the truth "Alright, I give in, I need something for the ADD : PI that ruined a lot of my school years and work years, methylphenidate makes me have seizures (it did back when I was 17/18 and I never touched a ritalin pill after that, just 3 weeks of "treatment") so I was scripted Dexedrine, because that is paid for by gov insurance, while Adderall XR isn't and the government doctors at the ministry of health have to approve of your doctor's script and have forms filled yadayada same with Vyvanse....i know it doesn't make sense....Dex IR and Dex spansules (all brand name too, we dont have generics for it) are awwright with em. Probably some doctors up the chain really love their dexies....but I notice how these lack the mdmx or whatever there is that makes you want to fuck for 48 hours in these, maybe its just that meth is more sexual...adderall XR 25mg when I got it at first was also very pervy, lol, but it was too expensive for me to pay all for it, 135 dollars for 30 speed pills just isn't right with me.
Ya man i m born in Qc but im 100 % european. Ive heard of the gears of wars pill but never tried it. I hate methyphenidate too, it makes edgy and paranoid whitout any ehuproia. Coke and ice ftw lol. Ive beend on adderal for a year.... 60 mg a day xr but i would eat like 200-250 mgs in a couple of days then get drunk and stoned as hell and sleep a few hurs,repeat cycle,when i ran out i turned to the loyal ice pills. Iyeah i noticed too ICE pills and Clocks were making me horny like a mtufucka hahahaha. My doc made me laugh, i was in a DPG ddetention youth center, he knew i had a stim absue history, he wasl ike yeah imma give hyou some adderal. I want to get on dexies though, ive tried them and there way cleaner the nadderal. Adderal has that dirty ass felling when you abuse it.
 
Ah c'est bon. J'aime la ville de Montréal. Je pense à déménager là-bas. J'aime la sensation européenne de l'endroit. Cela me rappelle la maison.

My French is rather rusty BTW =D

That read just fine! unless you cheated and put that through google translate...it sounds a little france french, and not as Québécois (north american french) ;)

Québécois correction : Ah c'est good. J'aime ça Montréal comme ville. J'pense bien déménager là-bas moment donné. J'aime l'ambiance européenne. Ca me rappelle mon chez-nous.

=D

As for myself I only moved in that city because the second BA I decided to take once I got bored with being a chemist....(I wasn't so good either) and the degree in computer networking I wanted to take was only available in da MTL....I come from way up north so sometimes this city's disgusting humidity making 25c feel like you're walking through 38 to 42 c of piss up to your neck isn't something I got used to yet....and obviously since I come from the 10th and last metro area of Canada, which is a small town by american standards, 175 000 people or so and it is very vast (it was the result of several 40-50k people towns merging over a large territory) makes me find french and english montrealers both equally snob sometimes. And the culture shock was quite something, my hometown is 99% white and catholic, here at first I was annoyed, not racism, just annoyed by so much difference, being unused to so many different cultures showing up right and left. I got used to that for the most part, especially when I go to a dépanneur that is ran by an old asian guy who has problems with both french and english going "DIX!" for a 6 pack of heineken when it's 10,76, so I give them 10 dollars and that's it ;)

The north americanisation of the language makes it so that we use english words thrown in since such a long time, especially in mechanics language and also computers and we use contractions a lot like american english does.

And yeah...eastern canada is bizarre, not only milk comes in bags(only if you buy it this way ugh) but meth comes in pills! Crystal or "Ice" when used it is almost only used in mtl's gay village..makes sense, i'm not a big fan of meth and when I would eat methbombs sometimes I'd get so horny I'd have intrusive thoughts of getting with somebody of the same sex, which still disgusted me as they happened, but I just felt like I had to FUCK SOMETHING RIGHT NOW. So I would look at all that straight porn I downloaded and got bored of over the years, I got so much but when I became a bit older and had sex regularly with women, porn lost a lot of its appeal, but thankfully I had it then when I would end up alone awake at 6 am cos i was eating and snorting meth pills during festivals and parties and didnt want to cheat on my far away girlfriend....meth is fucking insane like that, I never set foot on Beaudry and the one after that on the metro's green line, I did get out at frontenac but the place isn't extremely gay, the upper class gay people (among a lot of straights, the line starts to blur around that part..) live there and I never was offered crystal meth "ice" over there when I was in that neighborhood.

I'm pretty glad whoever controls the meth market outside of the crazed homosexual orgy party scene are decent enough to sell their meth in a way most people use as eaten and snorted....somehow those ways of confusing meth are all much milder than what seems to happen to those who smoke it (smoking the pills dont work...its made of that crank powder from the 80's and 90's that I heard bikers in the USA used to do and deal a lot...doesn't surprise me out bikers decided it was the way to deal it too)...a lot of these meth pills test positive for beta blockers too, small dosages of atenolol is often found from them.

And we also have this thing that seems so weird to the rest of the world outside quebec and the atlantic provinces, "mescaline" which is really pcp cut with lactose, it has lost some popularity but I know it is still out there, since the 70's, and somehow even if I saw human trainwrecks early on when i started to toke and drop lsd, I never was much interested in doing pcp, but once I did because I saw what starting material the people selling this stuff would use (some sort of pcp yellow to greenish putty) which they call "pure" but it's gotta be around 20% pure because "mescaline" as it is made is 1g of that thing to make anything between 10 to 18 grams of "mess"...which people snort or eat, the stories I heard of people snorting so fucking much of it, like snorting 1/4's of mess because they liked it so much. That putty is strange, it isn't smokable most of the time, so it doesn't have this characteristic of american pcp, people usually know their dosage, it is so cut to death (thankfully with inactives, unless you're allergic to lactose, lol, sometimes quinine is used to, isn't that a heart medication sometimes?) i don't know what it is they use to mix the liquid pcp with it, I know the liquid pcp does go around and they call it 1/50 to 1/100 meaning 1g of it will yield 50 to 100g of mess....it's so fucking bizarre I know.

I would prefer to put my hands on the "pure" when it was known as 1/50 and put a tiny bit of it over a joint and experience the whole noise I heard americans go, especially my old fav rappers of the late 80's and 90's the beasties, dust, and i agree there is something different to the experience when it is smoked, a lot more stimulant, i can see how someone with aggressive tendencies could feel euphoria from the analgesia and stimulant feeling....while eaten or snorted pcp was a lot more like a weird ass psychedelic (that was before I knew anything about dissociatives) and K wasn't available yet when I was trying that shit....I've only used it about 8-10 times but it was pretty damn fun and it made me empty pool tables in front of a new girlfriend I would still feel nervous in front of, it would really boost my confidence to the max...I remember how it made me also beat all of guitar hero 3's songs with 5 stars and 100% scores at hard one night when I decided to do it.

What a bizarre drug pcp is....and I mention all of this now..because I don't know...I've had a lot of dexedrine and feel chatty...

I can add that some people here would indeed make mdma+meth+pcp gelcaps...that particular person I knew of would make those and even throw in pieces of blotter he would cut off with scissors, what a crazy scumbag that guy was, so funny to know he's totally straight now and never went to prison or never was murdered.

Probably because he didn't ever sell anything with PMA in it. (guess you didn't see that comin).

I'm gonna go drink a couple beers downtown and chill, my brain is going fast like a 777...
 
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