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Misc intranasal phenibut

X

xxxyyy

Bluelighter
Joined
Aug 27, 2011
Messages
1,498
Location
germany
oral phenibut is pretty wasteful because of the first-pass effect, so i've been experimenting with different ROAs. anyone who ever snorted it will know that this works well, however it's only a viable option if you're extremely fond of pain. however, i found a way around that and i figured i'd share it since it works really well. aside from the phenibut you'll need:
one 5ml syringe + another syringe (doesn't matter which size)
saline
baking soda
optionally cotton or a cig filter

first, mix your desired amount of phenibut (500mg is my go-to dose) with 4ml saline in a large spoon, stir then heat until it looks like most of the powder is dissolved. then i run it through a cig filter but this is purely optional, drawing it into the 5ml syringe. clean your spoon, add a dash of baking soda and 1ml saline, heat and stir until the baking soda is dissolved. draw into second syringe. squirt the baking soda/saline mix into the phenibut solution. now time is of the essence, as it will start foaming like crazy. stick into nostril, slowly squirt the solution home while snorting. voila, no more burn and a quick and pronounced effect.
 
I've done this before without heating, just plugged it after it stopped foaming. It worked pretty well. I'm curious if it works as well as the new "free amino acid" version that is designed for sublingual use.
 
ohhh man. i once snorted maybe like, 500 mg or 1 g of powder phenibut and i regretted it. it burns! not a big fan of phenibut, it just makes me feel weird; the effects that it does have do definitely kick in faster when it is snorted vs when it is consumed orally. i'll stick to my etizolam...
 
xxxyyy said:
oral phenibut is pretty wasteful because of the first-pass effect, so i've been experimenting with different ROAs. anyone who ever snorted it will know that this works well, however it's only a viable option if you're extremely fond of pain. however, i found a way around that and i figured i'd share it since it works really well. aside from the phenibut you'll need:
one 5ml syringe + another syringe (doesn't matter which size)
saline
baking soda
optionally cotton or a cig filter

first, mix your desired amount of phenibut (500mg is my go-to dose) with 4ml saline in a large spoon, stir then heat until it looks like most of the powder is dissolved. then i run it through a cig filter but this is purely optional, drawing it into the 5ml syringe. clean your spoon, add a dash of baking soda and 1ml saline, heat and stir until the baking soda is dissolved. draw into second syringe. squirt the baking soda/saline mix into the phenibut solution. now time is of the essence, as it will start foaming like crazy. stick into nostril, slowly squirt the solution home while snorting. voila, no more burn and a quick and pronounced effect.
Click to expand...

could you explain the 'first pass' effect? snorting phenibut to me honestly seems like a ridiculously stupid idea. isn't it common knowledge that intranasal is not an effective ROA for most drugs? unless you're doing lines of cocaine or speed, but people who snort benzos or opiates definitely don't know what they're doing. i don't know how you would get a 'high' from phenibut by snorting it.

alovesupreme said:
ohhh man. i once snorted maybe like, 500 mg or 1 g of powder phenibut and i regretted it. it burns! not a big fan of phenibut, it just makes me feel weird; the effects that it does have do definitely kick in faster when it is snorted vs when it is consumed orally. i'll stick to my etizolam...
Click to expand...

I vehemently disagree. phenibut is wonderful.
 
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timsul999 said:
could you explain the 'first pass' effect?
Click to expand...

The first-pass effect (also known as first-pass metabolism or presystemic metabolism) is a phenomenon of drug metabolism whereby the concentration of a drug is greatly reduced before it reaches the systemic circulation. It is the fraction of lost drug during the process of absorption which is generally related to the liver and gut wall. -Straight from the wiki page

timsul999 said:
isn't it common knowledge that intranasal is not an effective ROA for most drugs?
Click to expand...

No.

timsul999 said:
people who snort benzos or opiates definitely don't know what they're doing.
Click to expand...

Really? Why don't you check the nasal bioavailability of oxymorphone compared to its oral b/a and then tell me snorting opiates is pointless. I'm not trying to sound rude but you seem very misinformed. My apologies to the OP for getting off topic
 
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Oh ROXIanne! said:
The first-pass effect (also known as first-pass metabolism or presystemic metabolism) is a phenomenon of drug metabolism whereby the concentration of a drug is greatly reduced before it reaches the systemic circulation. It is the fraction of lost drug during the process of absorption which is generally related to the liver and gut wall. -Straight from the wiki page



No.



Really? Why don't you check the nasal bioavailability of oxymorphone compared to its oral b/a and then tell me snorting opiates is pointless. I'm not trying to sound rude but you seem very misinformed. My apologies to the OP for getting off topic
Click to expand...


okay, fair enough, but most would be snorting tylenol along with the opiate. I'm not familiar with the roa ba for every drug, but it's pointless to snort everything you get your hands on and count on it being as reliable as taking it orally.

i didn't know that phenibut had that, i thought it was a prodrug and took awhile to metabolize. hence the 4 hour onset.
 
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>
ebola? said:
I'm more interested in the viability of reaction of the compound to a salt where phenibut is the anion. Could this be as simple as titrating phenibut into a dilute NaOH solution?
Click to expand...
>>
sekio said:
Yes, titrate to ph 7 (6-8 will work) where the compound is doubly protonated and hence very water sol.

I think the molar ratio is 22.2% the weight of your phenibut acid in naoh.
Click to expand...
 
Sorry i'm REALLY bad in chemistry...at least in theory ;)

Does that mean i just dissolve the Phenibut powder in NaOH till i reach ph 6-8? Is it really that simple?
 
^ But regular Phenibut seems very caustic...i don't think it's good news for your backdoor, or how you're preparing your dose?

And to quote myself...
THCified said:
Does that mean i just dissolve the Phenibut powder in NaOH till i reach ph 6-8? Is it really that simple?
Click to expand...
 
i haven't had pH paper strips around so i did a taste test. if i licked a little of the solution and it was thoroughly unpleasant/acidic, i'd add more baking soda. i can only discern it by taste, optimally it should taste salty with just a hint of acid bite in it. this is what you're after and works best both up the nose and up the butt.
phenibut reacts visibly with baking soda, and the end product, if taken orally just tastes very salty but it doesn't feel like you ate a scotch bonnet and chased it with distilled vinegar. neither intranasal nor retal administration produce any pain or unpleasantness.
 
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THCified said:
Sorry i'm REALLY bad in chemistry...at least in theory ;)

Does that mean i just dissolve the Phenibut powder in NaOH till i reach ph 6-8? Is it really that simple?
Click to expand...

Indeed it is,
From Sekio's molar ratio you should expect to use roughly 4.55g phenibut per gram of NaOH
Do report back if you try this! I'd be very interested to see how it turns out :)
 
THCified said:
Sorry i'm REALLY bad in chemistry...at least in theory ;)

Does that mean i just dissolve the Phenibut powder in NaOH till i reach ph 6-8? Is it really that simple?
Click to expand...

Sodium hydroxide is a skin irritant and a caustic base depending upon the molarity of the NaOH. I suggest using diluted NaOH.

Please use extreme caution preparing and make damn sure that your pH is dead on before plugging this. Otherwise, things could become very unpleasant/dangerous for your ass.
 
^
Truth, you do not want to plug excess sodium hydroxide. Eye protection is also a must when handling NaOH.
 
brutus said:
Sodium hydroxide is a skin irritant and a caustic base depending upon the molarity of the NaOH. I suggest using diluted NaOH.

Please use extreme caution preparing and make damn sure that your pH is dead on before plugging this. Otherwise, things could become very unpleasant/dangerous for your ass.
Click to expand...

I couldn't possibly agree more.
 
Toucan said:
^
Truth, you do not want to plug excess sodium hydroxide. Eye protection is also a must when handling NaOH.
Click to expand...

Along with gloves. I recommend using nitrile. But if someone is reading this and doesn't already know this elementary information, then they need to think twice before going ahead with this simple chemistry experiment.
 
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