Personally, using marijuana in the form of a bong rip once every two to three hours is how I get the most out of life. Using any other drugs at all disrupts the harmony and balance I get out of using weed at this rate. Using weed any more than this will make me very lazy, and using weed any less will cause me to be more of an egotistical person and less chill.
Man, tons of people smoke weed every day and are living the best version of themselves. It sounds like that's not the case for you. Of course many of them are burnouts too, since there is a fine line between use and overuse. However, there are a few people out there who used LSD or another strong drug just once, and would testify that it ruined their minds. I personally would advise that nobody in their right mind ever even so much as touch acid, and that those stronger psychedelics are complete and utter nonsense compared to the chillness of weed, which it is really difficult to do long term damage to yourself with. I personally used LSD a handful of times, and it fucked up my cardiovascular system due to how vasoconstrictive it is. I nearly died from the cardiovascular stress on a large dose of acid - that would never happen with weed.