• CD Moderators: someguyontheinternet
  • Cannabis Discussion Welcome Guest
    Posting Rules Bluelight Rules

[MEGA] Synthetic Cannabinoid Discussion - Take 3

Status
Not open for further replies.
Well, here comes the verbal lashing....but

It's a blend from a smoke shop (stupid, I know) because I rent a room in a house and can't have packages delivered. However, he has been in business for several years and is reputable.

It feels just like a strong indica for seriously 10 MAYBE 15 minutes at the most.
 
Depends on the day, but on average I would say 2 to 3 times a day (about three hits each time)
 
Can anyone with chemistry knowledge comment on possible dangerous side effects from STS-135 by referring to the molecule etc?

I had 100mg of this stuff, had a day off yesterday but had been vaping for 2-3 days prior. I don't plan to repurchase, however wouldn't mind finishing this batch. I have heard of weird withdrawal/headaches/etc from these synthetics in the past with previous families/analogues, let alone this far down the chain. Is it starting to get a bit pushy/risky or provided these are dosed correctly and not abused (few vapes a day at most) are these a suitable temporary substitute for cannabis?

I smoked lots of JWH-018 a few years back in spice blends and pure. I recently smoked another herbal blend and wasn't a fan of the high. STS-135 is reasonable, however I like my drugs, I noticed it seems to be a bit more of a chemically stoned/headspace and can be a bit stronger but much shorter duration. Quite similar to my recollection of JWH.
 
2ne1 is one hell of a nice smoke cheaper than the other noids to more thc than with others where you get mental trippy opiate Dissociative like not with this one you got up the dose its very nice
 
xTalK said:
Can anyone with chemistry knowledge comment on possible dangerous side effects from STS-135 by referring to the molecule etc?
Click to expand...

435px-STS-135_structure.png

^^ STS-135

the adamantane group (spiky bit at the top of the image) could potentially cleave off and form the chemical Amantadine:

Amantadine_stereo.png


from the Wikipedia article on Amantadine:

Indications

Parkinson's disease

Amantadine is a weak antagonist of the NMDA type glutamate receptor, increases dopamine release, and blocks dopamine reuptake. This makes it a weak therapy for Parkinson's disease. Although, as an antiparkinsonian it can be used as monotherapy; or together with L-DOPA to treat L-DOPA-related motor fluctuations (i.e., shortening of L-DOPA duration of clinical effect, probably related to progressive neuronal loss) and L-DOPA-related dyskinesias (choreiform movements associated with long-term L-DOPA use, probably related to chronic pulsatile stimulation of dopamine receptors).

Despite a 2003 Cochrane review of the scientific literature concluding that there is inadequate evidence to support the use of amantadine for Parkinson's, the drug continues to be prescribed for this indication.[1]

Influenza

Amantadine is no longer recommended for treatment of influenza A infection.
For the 2008/2009 flu season, the United States' Centers for Disease Control and Prevention (CDC) found that 100% of seasonal H3N2 and 2009 pandemic flu samples tested have shown resistance to adamantanes.[6] The CDC issued an alert to doctors to prescribe the neuraminidase inhibitors oseltamivir and zanamivir instead of amantadine and rimantadine for treatment of current circulating flu.[7][8]

Off-label uses

Amantadine is frequently used to treat the chronic fatigue often experienced by patients with multiple sclerosis.[9] Additionally, there have been anecdotal reports[10] and a small number of pilot studies[11][12] that show low-dose amantadine as a potential treatment for ADHD. Limited data has shown that amantadine may help to relieve SSRI-induced sexual dysfunction.[13][14][15]

Adverse effects

Amantadine has been associated with several central nervous system (CNS) side effects, likely due to amantadine's dopaminergic and adrenergic activity, and to a lesser extent, its activity as an anticholinergic. CNS side effects include nervousness, anxiety, agitation, insomnia, difficulty in concentrating, and exacerbations of pre-existing seizure disorders and psychiatric symptoms in patients with schizophrenia or Parkinson's disease. The usefulness of amantadine as an anti-parkinsonian drug is somewhat limited by the need to screen patients for a history of seizures and psychiatric symptoms.

Rare cases of severe skin rashes such as Stevens Johnson Syndrome[16] and suicidal ideation in patients treated with amantadine have also been reported.[17][18]

Livedo reticularis is a possible side effect of amantadine use for Parkinson's disease.[19]

...

Dosage and mechanism of action

A starting dose is often 100 mg once daily. All influenza B strains, many influenza A strains (and virtually all H1N1 "swine flu" strains) are resistant to amantadine, so a failure at this dose is likely due to resistance and not underdosing. For its anti-Parkinsonian effects, a starting dose of 300 mg once daily is normal, but can be increased to a limit of about 400 mg.

- The mechanisms for amantadine's antiviral and antiparkinsonian effects appear to be unrelated.

- The mechanism of Amantadine's antiviral activity involves interference with a viral protein, M2 (an ion channel),[23][24] which is required for the viral particle to become "uncoated" once taken inside a cell by endocytosis.

The mechanism of its antiparkinsonian effect is poorly understood. The drug has many effects in the brain, including release of dopamine and norepinephrine from nerve endings. It appears to be a weak NMDA receptor antagonist[25][26] as well as an anticholinergic, specifically a nicotinic alpha-7 antagonist like the similar pharmaceutical memantine.

Amantadine appears to act through several pharmacological mechanisms, but no dominant mechanism of action has been identified. It is a dopaminergic, noradrenergic and serotonergic substance, blocks monoamine oxidase A and NMDA receptors, and seems to raise beta-endorphin/beta-lipotropin levels.[citation needed]

Research in brain injury

In a 2012 study, 184 patients with severe traumatic brain injury were treated with amantadine or placebo for four weeks. In this study, the drug accelerated functional brain recovery.[27]
Click to expand...

each 1gram of STS-135 could potentially equal up to 400mg of Amantadine consumed.

2NE1 / AKB-48 / 5F-AKB-48 could all also potentially partially degrade/metabolize into Amantadine.

IDK if this is any better or worse than any of the other potential byproducts from this latest generation of cannabinoids...
 
I havnt tried it yet. Its available in low doses at high prices so im holding off for now. Im really curious about the how 5f-pb22 compares/ blends with mam. I really dont have the money to take the risk right now but if anybodys got experience to share that would be awesome.
 
its a lot nicer same strength i would guess maybe a bit weaker but nowhere near as insane or smacky . watch it with 5F AKB-48K that made me black out be sick and totally unable to register or even move for about 10 minutes just covered in sick it just goes black and thats that :)
 
Tried me some 5F AKB-48K with two mates today, its not bad. They found it to be on the weaker side where as i would say its about the same ime as UR-144. Good high, not overwhelming like UR, made tv fun but gave a mean case of the munchies, ill play around with it again soon
 
Thanks gold,fools! Im gonna have to check it out then. Do you think it would blend well with the mam?
 
^^ i'm not too sure i'm going to be doing some blending of my own hopefully to day with 2ne1 and 5F AKB-48K first time il really sit down and take note on how much to mix instead of just getting and smoking to get wasted
 
If youve been sick from these things i guess the best thing to do is like you say, just sit down and take note and not get wasted. Getting wasted on these cannabinoids never ends well for me
 
yer it was one wicked whitey lol iv been hospitalized while smoking ur144 because i had a fit on it normally i got them on a night while sleeping the most dangerous time but this one hit me mid afternoon and stuck me in hospital for the rest of the day and a bit of the next .

p.s. that was the last time it touched ur144 well knowingly anyway
 
foolsgold said:
yer it was one wicked whitey lol iv been hospitalized while smoking ur144 because i had a fit on it normally i got them on a night while sleeping the most dangerous time but this one hit me mid afternoon and stuck me in hospital for the rest of the day and a bit of the next .

p.s. that was the last time it touched ur144 well knowingly anyway
Click to expand...

Shit dude, thats rough. Play nice with these ones!
 
mydrugbuddy said:
is it just me, or does anyone else find that the noids take them to familliar half dream states every night ? Every night i seem to be picking up bits and pieces of whats going on. But each noid has a slightly different effect.
Click to expand...

they cause me to not remember my dreams too clearly
 
Status
Not open for further replies.
Top