^I pretty much wouldn't take seroquel with meth because it would pretty much block all the effects of the meth and you wouldn't get high....
The only way I could figure it being dangerous is, If you took a huge amount of meth and took some seroquel to come down or even it out, it might block the "high feeling" but the CNS stimulation would still be there...like you're heart racing and pounding, and it might be worse to take a knock-out dose of seroquel and try to go to sleep with your heart-racing...
It's the same way with benzos....They'll make you feel a lot calmer when you're on stimulants but they won't cancel out the CNS stimulation, even though it might feel like they're causing the stimulant to completely wear-off, it's still active until it wears off on it's own....
It's bad to take "black-out doses" of anything to come down from amphetamines......If you're using a little seroquel at the end to "come down", it's probably not a big deal...
Opiates, benzos and antipsychotics can all be highly sedating and trying to cut through all that with meth can be pointless.....that's the thing