Opioids Tapentadol closest to which opioid? Similar like Demerol?

[muie]

Which opioid would you compare tapentadol with most?

I have never had tapentadol but i've tried pretty much every opiate; heroin, codeine, tramadol, hydrocodone, hydromorphone, oxycodone, demerol, morphine, fentanyl, suboxone & methadone - recreationaly as well as in narcotic treatment.

Is tapentadol anything like demerol which is also synthethic and has its 'atypical' opiate effects in that it hits a bunch of other receptors as well. In my case every time i've snorted more than 200mg-300mg demerol i felt better than on most other opioids and enjoyed the extra effects on top of the opiate buzz. Also I do get a decent effect from tramadol although it is much more speedy than demerol and not as euphoric (to me).

p.s. one of my biggest concers with tapentadol from what i've read is the incidence of hallucinations/delerium type although many people dont report much of that they do say there is a visual change (ex: say theres a piece of lint on the carpet some people report seeing an animated bug so to speak). This also makes me wonder if the reported hallucinations have anything to do with tapentadol's grater effect on the receptors that the anti histamines hit (name slips my mind). The only opioid that created minor visual changes was demerol and i enjoyed that.

 

[Abhaya]

I've never tried Demerol, but honestly i'm not impressed by tapentadol. Some reports online compare it to oxycodone but i found it to be not so for me. I find it to be surely more opiate-like than tramadol (which i like by the way), but still very subtle, pleasurable but subtle. Surely not like any potent agonist you have listed. Furthermore the norepinephrine/SSRI part of the effects bothers me more than with tram, so i usually have to take it with a benzo or i freak out (but this is probably just me and i don't advise anyone with low to none opiate or benzo tolerance to do that - or at least do some research before you take stuff).

Having said that, keep in mind that i have it in a horrible formulation: palexia 50 mg. These pills are BIG, time released, they contain almost no active ingredient and they gel badly in water, to the point that i don't even want to plug them. The formulation can play a part here. The max dose i took was 200mg (4 crushed pills) taken orally. Not a great dose but i don't think that the risks/benefits ratio is worth going further than that. At this dosage i have not experienced any visual change (thank to God).

 

[muie]

Thanks for replying!

You mentioned that the norepinephrine/SSRI effects are worst than tramadol? Wouldn't it be a better less stimulating version of tramadol...can you please describe what you mean by freaking out?

Regarding taking a benzo or some downer with it I heard that Soma with Tapentadol is quite euphoric.

I too have heard of it being compared with oxycodone but slightly longer lasting with more of an energetic high than again I've heard it described as pure shit (I have heard these comments about tramadol as well, and in my opinion tramadol is okay far from shit).

The only person I know whose taken it is a buddy and he only had it once (150mg) and he said it was very nice, more uplifting than non synthetic or semi synthetic opioids however I've had fentanyl which I could hardly nod out on and in my opinion other than tramadol, fentanyl is the most stimulating opioid, more so than oxycodone or hydromorphone but its still euphoric.

Any replies and opinions will be gratley appreciated!

 

[sekio]

Chemically speaking, tapentadol is pretty close to an odd man out... I would say demerol/pethedine/meperidine is much closer to a "normal opioid". Tapentadol, being so heavily chemically modified, is almost into the territory of the pentazocine-type compounds.

In terms of biological efficacy tapentadol is much less selective for the "feel good" targets (mu-opi, DAT/SERT) than demerol is.

 

[Abhaya]

You mentioned that the norepinephrine/SSRI effects are worst than tramadol? Wouldn't it be a better less stimulating version of tramadol...can you please describe what you mean by freaking out?

I hoped too that tapentadol would be a less stimulating version of tramadol, as this is what i have read more than once somewhere on the net, but it gives me the same speedy feeling of tramadol, only worse. But this can be disputable. Maybe you won't feel this way or actually you will enjoy the abundance of neurotransmitters, while i usually read it as "i'm panicking". I'm kinda anxious.

I too have heard of it being compared with oxycodone but slightly longer lasting with more of an energetic high than again I've heard it described as pure shit (I have heard these comments about tramadol as well, and in my opinion tramadol is okay far from shit).

Personally i feel that neither tramadol nor tapentadol can be used as other agonists. You can't really just add to your dose to get the same opiate effects but stronger, they are odder than that. Also, probably tolerance plays a big part here. If someone have even a medium tolerance to opiates, he could find himself needing easily 400mg or more of tapentadol in one go to feel anything (i needed 200mg with a low one), and these dosages are dangerous for what i read.

The only person I know whose taken it is a buddy and he only had it once (150mg) and he said it was very nice, more uplifting than non synthetic or semi synthetic opioids however I've had fentanyl which I could hardly nod out on and in my opinion other than tramadol, fentanyl is the most stimulating opioid, more so than oxycodone or hydromorphone but its still euphoric.

These things are pretty subjective. For me "tramadol+more opiate feeling" is a good description of tapentadol, and if you like tramadol you will probably like tapentadol too. I too like both as now i don't have much access to more potent stuff, but i can't really tell you that i love them, it depends on what you like in an opiate. For me the comparison, the one that i like the most, is morphine so even oxycodone feels a bit too cold to me, and tapentadol is far worse in terms of "warmth".

 

[Halif]

Good post, Abhaya


I've been waiting for a tapentadol thread to come up because this is an interesting substance and given its complexity I'm sure we'll see some really polarizing opinions on it.

I'm a fan of the "natural" opiates/opioids - anything that came from a poppy, basically - over the fully synthetic ones.

I've only had tapentadol twice: 50mg and 100mg.

I have a fairly large tolerance to opiates but I wanted to keep the doses of this low because I take an SSRI, so I really shouldn't be taking it at all. I have combined many things before which I shouldn't have, and also have many years of experience under my belt. I'm just putting this here as a disclaimer.

<General note for HR purposes and newbies: tramadol and tapentadol are not 'just' opioids - they also affect parts of the brain which some common anti-depressants do. The combination of anti-depressant and one of these opioids could be very dangerous. Therefore, people who take anti-depressants and are interested in either tramadol or tapentadol should do lots and lots of reading about this subject. >


My experiences with this substance were underwhelming, but I'm not the best to judge because of various other things I have in my system on a daily basis. However, I can add one subjective note: With both doses - particularly the 100mg - I had some crazy images/scenes/hallucinations when I went to bed.

I mention this because I didn't notice much in the way of analgesia, sedation, mood change, etc, after I took it, and I hadn't really expected much anyway, but the one really stand out thing I did notice on both occasions was the exaggerated mind activity which occurred when I was in bed waiting to sleep.

It was more like the after-effects of a psychedelic than any other opiate/opioid I've tried.

 

[jmmac]

I've just been switched to Tapentadol (Palexia Sr) from MST Continus (Uk version of MS Contin) I had been on 70mg of MST twice daily and now that's been switched to 200mg of Palexia twice daily. Firstly I only take them for pain and only at the prescribed dose. I think they're brilliant in terms of less side effects than Morphine although the pain relief itself is comparable. I haven't noticed any euphoria etc but I was already on a high dose of Morph anyway.