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Benzos Alprazolam Tolerance Skyrocketing - Advice?

Thanks for all the info guys. And also, I don't need a warning on the "danger" of mixing benzodiazepines with methadone. There are people in the other drugs forum asking how to inject certain things and plenty of other things that puts lives at risk JUST as much.
Yes of course, we don't mean to warn you about the dangers of this combination unnecessarily; it's just that it's a particularly notorious combination for killing people unexpectedly. Often the user will have methadone building up in their system due to the long half life. Sometimes this leads to unexpected overdoses. We just like to make sure no one is going to unintentionally overdose; it's really sad to know that people go through this, let alone that people could die from it.

I only smoke 2-4 xcogarettes a day and am planning on quitting altogether, which I've done cold turkey twice in myt life.

Definitely quit then; why did you go back to them if you had already quit? Just curious. Congratulations on knowing that you can quit by having done it twice before. :)
 
Yes of course, we don't mean to warn you about the dangers of this combination unnecessarily; it's just that it's a particularly notorious combination for killing people unexpectedly. Often the user will have methadone building up in their system due to the long half life. Sometimes this leads to unexpected overdoses. We just like to make sure no one is going to unintentionally overdose; it's really sad to know that people go through this, let alone that people could die from it.



Definitely quit then; why did you go back to them if you had already quit? Just curious. Congratulations on knowing that you can quit by having done it twice before. :)


@Captain.Heroin - Wow. I'd have to say your comment is the only one so far that I've felt is sincere. Thank you.

Indeed I understand the warning of methadone+benzos. I myself have had to warn others that this combination is EXTREMELY deadly and often creeps up on people and leads to SO many accidental, unexpected deaths. Had the person been able to comment on their accidental death, they would've said "But I only took one xanny bar, what gives??"

I quit the first time when I left rehab in early 2011 cold turkey after a pack a day for 6 months, then I quit cold turkey again in early 2012 after leaving rehab, again, smoking a pack a day for 3 months. I went back to it because my sister smokes and I moved back home to live with my parents recently while I'm working and saving money, and she's pretty much doing the same, and seeing her outside smoking all the time makes me consider it. Also, I did a 6 week outpatient (night class 5:30-8) rehab for my heroin addiction back in october-ish and started smoking again for the second time (the first time I started smoking again was whwn I went back to rehab, which is almost impossble not to smoke when 99% of the patients and employees at the rehab smoke lol). Since then, I started smoking 15-20 cigarettes a day, then recently I went down to 10 a day, and now I only smoke 2 in the morning, and 1-2 in the evening. I'd love to quit altogether of course, but everyone at my work at the grocery pretty much smokes (especially in the department I work in) and it's so hard to say no when they ask if I wanna take a smoke break with them, haha.

At my work, if you smoke, they tend to be more lenient with you taking several 5-minute breaks per shift than if you weren't a smoker, you'd just be standing there.

Anyway, thanks again everyone and C.H for the replies, I've got the info I needed and I'm going to take a few weeks off the alprazolam if not a few months in order to reduce my tolerance. I think it was just the Pakistani quality of the Xanax pills I was getting from there. The European Pfizer "Upjohn 90" lavender tablets (seen here http://min.medicin.dk/resource/media/C3322DD4 ) are of much better quality and while they were both supposedly 1mg tablets, 2 of the 1mg upjohn 90 tabs perform as I'd expect, rather than me having to take 6-8 of the Pakistani "Parke-Davis XANAX 1.0" tablets. the tablets are entirely different though. different shade of purple, different size, the upjohns melt in your mouth rather than the parke-davis tabs being hard and crunchy, and on and on and on.

Basically I don't think my tolerance necessarily skyrocketed overnight, I just happened to be taking tablets that had a weak alprazolam content. Silly me. Because wednesday night at bedtime I took 3 of the Upjohn 90 tabs along with my 1.5mg of clonazepam and I was blown away and EXTREEEMELY relaxed. Knocked me straight out.


Thanks again for all of the comments everyone. If someone could close this thread that would be great too.

-CW
 
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Of course man. Everything you said absolutely makes sense. I'm an addict. I do stupid shit. Not that it covers for my actions but it just got a little out of control too quickly. I have a job and extra cash and an online supplier that I can order Xanax through so amazingly cheaply and get 2 days later, it became a daily thing of just 1-2mg extra then it was 5-10mg extra. Just stupid actions from a dumb addict. I'm lucky I have my kpin RX to "fall back on" but I don't really want to be taking these xannies for a while. It's the same things as heroin. It feels so good at the time but you're taking a loan out on your body basically and when you have to pay it back, it's fucking horrible. Indeed methadone plus Xanax is a death combo. Today I passed out and don't know honestly how I woke up. I have been taking the xannies on the side (my second favorite drug of choice, behind opioids), but I'm putting them down for a month or a few so I can recover. You're exactly right. I knew what could happen. But I had never gone through any kind of benzo withdrawal before because last time I was on Xanax I was prescribed it and managed to not run out early. Anyway, thread closed. Thanks for all the input.


I'm sorry to hear it buddy, I just hope that you learn from this experience. I know exactly how easy it is to pickup a dependency when you have easy access, but you gotta be more powerful than the drugs you ingest! :)

My advice was sincere if you ask me, but w/e
 
Any benzodiazepine will cause skyrocketing of tolerance due to the way chronic benzodiazepine administration will cause elimination of the benzodiazepine (BZD) site.

GABAA-receptor-protein-example.png


This is what the GABA-A receptor sub-units should look like.

After you are dependent on benzodiazepines long enough, the sub-units alpha 1 and gamma 2 dissociate from each other, which destroys the benzodiazepine site.

This is primarily what causes a skyrocketing tolerance to benzodiazepines, and can happen with any/all benzodiazepines, not just alprazolam.
j


this is both fascinating amd frightening. if the bz receptor site is destroyed though, how can benzos still bind to it? i would assume if it was completely destroyed, one would go into withdrawal even with the consumption of exogenous benzos, which isnt the case.
.. if you could clarify, that would be great

also, it must (at least partially) repair itself with a long enough taper, right? some people recover almost completely with proper titration
 
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i agree with people here, taper off while you can or youll jus keep uping the dose. 2 years ago i had a bad benzo addiction. i was taking aroung 20mg of xanax a day for awhile n coming off that dose at a detox center was god awful.
 
i agree with people here, taper off while you can or youll jus keep uping the dose. 2 years ago i had a bad benzo addiction. i was taking aroung 20mg of xanax a day for awhile n coming off that dose at a detox center was god awful.

This^ and all others get the fuck off why you can man, I would go with a fast taper of kpins and then after take low dose of pregabalin or gabapentin if availible. If your prone to PAWS and many people are with benzos It really helped me but i stayed on to long and now dealing with those w/ds and they arent fun either but not as bad. Shit i quit 6 months ago from abt a year of heavy benzos still have lots more rebound anxiety than before, get out before your in risk of seizure soon enough scene friends with that not cool dude.
 
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'Just switch to like heoin for 2 weeks, your tolerance will dissapate, another drug solves everything hahahahahaa


tru tho dats what i do..te sum goodassblack...just g
 
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'Just switch to like heoin for 2 weeks, your tolerance will dissapate, another drug solves everything hahahahahaa


tru tho dats what i do..te sum goodassblack...just g

Well, not bashing your opinion or anything, but thats not the greatest idea for trying to manage benzo tolerance/addiction to switch to smack. I mean for me and many others that would just result in a dual/poly drug addiction which is the last thing you want. That may be your choice, but in the sake of harm reduction please go with a diazepam taper with some lyrica added in short term like 100mg 3x daily for about a month or two til the PAWS settles. Worked for me at one time, but sure is a bitch, be safe take care!
 
tricomb....ban me all day long that's fine. I've been reading this board for years and years, hardly post anymore, but every single thing you say makes me think you are a douche. You rave and rant about "researching the consequences" about putting something into your body, when it's pretty clear you're on a regimen that'd be pretty debilitating to just stop. Most people know what they're getting themselves into, and you, like me, like the OP, and most others on this board, are addicts because we choose to ignore the details. Yeah I get what you say is in harm reductions sake, but fuck man, you come off as a huge dick. This isn't a harm reduction via being a cocksucker board, it's just harm reduction.
 
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