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  • BDD Moderators: Keif’ Richards

Ritalin and amphetamines, safe combo?

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Okami

Okami

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Jun 3, 2011
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Okay so I don't have enough of either to enjoy the night, can I combine the two? Any adverse reactions that can happen? Do the two add together or will they for some reason counter each other out? I read a thread on a different (and dumber) drugs forum that claimed that ritalin mechanism counters amhpetamines but didn't give a reason.
 
Okami said:
Okay so I don't have enough of either to enjoy the night, can I combine the two? Any adverse reactions that can happen? Do the two add together or will they for some reason counter each other out? I read a thread on a different (and dumber) drugs forum that claimed that ritalin mechanism counters amhpetamines but didn't give a reason.
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As far as i'm aware Ritalin is more or less an Amphetamine, with a similar but slightly differing structure.
 
I don't know why I'm answering this question so many times over the past two days, but DO NOT COMBINE THESE SUBSTANCES!

Amphetamine causes an excess amount of dopamine to be produced. Ritalin then prevents the dopamine from leaving the synaptic cleft, leading to a range of horrible and adverse side effects from tachycardia, psychosis to respiratory collapse.

I repeat DO NOT MIX THESE. Thank you.
 
synthetix said:
I don't know why I'm answering this question so many times over the past two days, but DO NOT COMBINE THESE SUBSTANCES!

Amphetamine causes an excess amount of dopamine to be produced. Ritalin then prevents the dopamine from leaving the synaptic cleft, leading to a range of horrible and adverse side effects from tachycardia, psychosis to respiratory collapse.

I repeat DO NOT MIX THESE. Thank you.
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so general rule - mixing DA and DARI couses horrible side effects? but do they potentionate each other too? thanks. (seems some people enjoy combo of mdpv and methylone/mephedrone, I think some company was even selling such tablets...).
 
synthetix said:
I don't know why I'm answering this question so many times over the past two days, but DO NOT COMBINE THESE SUBSTANCES!

Amphetamine causes an excess amount of dopamine to be produced. Ritalin then prevents the dopamine from leaving the synaptic cleft, leading to a range of horrible and adverse side effects from tachycardia, psychosis to respiratory collapse.

I repeat DO NOT MIX THESE. Thank you.
Click to expand...


Good post synth, but I have to correct you, amps don't produce dopamine, they release dopamine, binds to dat, and is more or less a maoi
 
Sorry, I was just annoyed at the amount of times I had answered that question I didn't really answer it fully correctly. But anyway, don't mix them.
 
as far as I know, combining the two substances in the right way is the healthiest thing you can do (except taking nothing would be much better). I was reading in the animal studies which show that amphetamine and metamphetamine is neurotoxic (in high doses), that when you give at the end of the trip some methylphenidate (ritalin) then there is no damage to the neurons. Reason might be that methylphenidate is a dopamin reuptake inhibitor, which inhibits the uptake of the excessive dopamine caused by amphetamine, which would otherwise result in posining the cells with too much dopamine.

If you combine amphetamines and methylphenidate (ritalin) then you will have lots of dopamine. So when combining, lower the dose of the amphetamine you would normally take and make sure that you take some methylphenidate at the end of the amphetamine trip...

And my special recommendation for coming down is to take a not to big dose of phenibut. This calms, makes you feel well, lets you sleep and has neuroprotective properties.
 
logarithm said:
that when you give at the end of the trip some methylphenidate (ritalin) then there is no damage to the neurons. Reason might be that methylphenidate is a dopamin reuptake inhibitor, which inhibits the uptake of the excessive dopamine caused by amphetamine, which would otherwise result in posining the cells with too much dopamine.
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very interesting post indeed, thank you very much for the info.
 
to be honest, they say that MPH is neuroprotective in that it stops the uptake of excess dopamine, but i still find that hard to believe. considering that cocaine is fairly neurotoxic and acts in a similar mechanism, when given an excess amount of dopamine inhibited in the sypanses, when finally released the end result would be even more toxic.
 
Okay which would be more harmful 30mg of amphetamine or 15mg amphetamine with 15mg MPH?

Edit: I don't really see why if your doing both but significantly less than you would do of 1 it would be much more harmful
 
Well mainly, the effects will synergizes and you probably will feel squirmyfrom excess norepinephrine in your synapses. Ritalin is known for being dirty and causing a harsh cone down, why would you taint your amphetamines with it? It will probably ruin the amp euphoria and make the conedown that much worse. You will probably be fine and no long term damage will happen if you keep your dosages low, but the experience will be very dirty and you probably will feel anxious and over stimulated.

You seem pretty adament about trying the two, so go ahaeadx combine them. If you feel like shit then you know that it probably isn't the best idea.

Combining the two is more dangerous than just taking a higher dose of amphetamines because the effects will synergizes and possibly cause tachycardia or even serotonin syndrome. When you combine the two, its not like just adding more amps which would be like 1+1=2, but more like 1+1=4 , just like combing benzos and alcohol. I doubt you will have long lasting malacious implications if you combine the two, but do your body a favor and don't combine the two. The combo will put stress on your body and brain.

But fi you are like me, I didn't care about what people said and combined drugs. I found out the hard way thT combining drugs is very dangerous.
 
what happens if you abuse both I don't know. But if you come down from amphetamine you could take some methylphenidate (orally). I suggest that is the safest form. But probably you will stay awake much longer, (thats why I suggested phenibut) but perhaps when you take the mehtylphenidate, your neurotransmitter system stabilizes a bit and the comedown wouldnt be that bad. But who knows.....

... did you survive?
 
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The fact whether or not methylphenidate releases minuscule amounts of dopamine is still debated. Nonetheless, since it's an established DRI, methylphenidate will do to amphetamines what SSRIs' do to MDXX. Releasing agents and reuptake inhibitors never mix well.

Combining the two is safe and does not produce more tachycardia then any stimulant+stimulant would but IME the combination is nastier than combining cocaine and amphetamines.

You seem he'll bent from your other posts to combine stimulants, but I can only reiterate my previous responses to your other posts that mixing any two drugs in the same classification such as dissociative's, benzodiazepines, stimulants, and opioids is mostly an ineffective waste of drugs, even though there are exceptions.
 
I resent you saying that I'm hell bent on combing stims. I didn't end up combing the two, I am indeed still alive. I merely trying to clarify what the risks and cons are to if they are in my opinions worth taking.
 
I don't think you should feel resentful at all, if you think I insulted you in anyway, I assure you that wasn't my intention. As I pointed out the combination is safe but ineffective.

I was referring to your earlier thread where you were asking about combining MDXX with other amphetamines which in my opinion is another waste of drugs regardless if there is a sample which enjoy it.

As you pointed out drugs of different classes work synergistically to a much better effect than combing drugs of the same class, unfortunately for reasons that we sometimes don't understand eg: Ketamine+MDXX, GHB/GBL+MDXX etc.

You often take advice to heart too extensively, listen to the advice given to you and stop trying to defy logic to boost your high. If amphetamines don't work alone for you, find a new class of drugs that suites your taste.
 
Amphetamines do work alone, just not when I can't procure enough of them for a single night. As for the other thread. Again MDMA also works fine alone, however via an unfortunate series of events I ended up combining a small amount of MDMA and amphetamine and it was extremely nice and I would not say inneffective at all. However unfortunately it's not a particularly safe combo as was pointed out. I'm not trying to defy any logic just merely work out by what rules, as someone who is not a neuroscientist or biochemist, these things seem to work.
 
Amphetamines do work alone, just not when I can't procure enough of them for a single night.
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Well that's unfortunate, but as I and other users have pointed out, and you may have discovered yourself, methylphenidate is not the answer.




Thread answered, end of subject.
 
Chromophobia said:
Well that's unfortunate, but as I and other users have pointed out, and you may have discovered yourself, methylphenidate is not the answer.
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I didn't try it, as I stated above.

Although the question has partially been answered there is definately more that can be added, for example by people who have themselves tried this combo and have any experiences they would like to share, methinks there's definately more that could be expanded upon.
 
As mentioned, this thread has come to an end - and is veering OT now.

I'm going to close this one.

Please take note all that want to use these drugs simultaneously that is VERY dangerous and shouldn't be attempted.
 
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