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The Big & Dandy Methoxetamine Thread-11th Dose-50 grams and a kidney later..

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words of wisdom from the guy who synthesized it

The arylcyclohexylamines light up too many of the reward systems in the brain, with the dopamine-reuptake inhibition, the NMDA antagonism, and the µ-opioid affinity. They lend themselves to abuse and escape to fantasy. I used to find myself raving about chemicals I had only tried once or twice, saying they were Huxley’s soma or moksha, or Polidamma’s Nepenthe. I’ve come to realize that dissociatives have a really dark side to them that classic serotonergic psychedelics don’t.
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One of the saddest thing that happened to me is the 'magic loss' after abusing this substance. I do not think that I will ever reach states that I used to.

But this has also a good side to this. I can now move on with life searching for new things, exploring it further. I hope I will break free from the psychological dependence sooner or later.. Otherwise I am fucked :|
 
Identity888 said:
I guess it is because it binds to so many receptors:

1. Results of binding assays of methoxetamine

bMksq.png
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Those aren't the results, those are the receptors they screened for. Table 2 (not in the picture you linked) shows the results, and the results show that it only binds to SERT and the NMDA receptor.
 
I apologize for misinformation then!! I really thought it binds to all those receptors.

But what about dopamine or opioid receptors? I have read many posts regarding those with MXE. Does it really effect ONLY SERT and NMDA?

I have very minimal understanding about neuro chemistry by the way.. Sorry again.
 
Identity888 said:
But what about dopamine or opioid receptors? I have read many posts regarding those with MXE. Does it really effect ONLY SERT and NMDA?
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Considering the addictive properties of MXE, it is very likely that it affects dopamine (at least indirectly).
 
WSH said:
Considering the addictive properties of MXE, it is very likely that it affects dopamine (at least indirectly).
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Anything that makes you smile is affecting dopapine ;)

I find that MXE is addictive simply because I like it. I just use it at night & have never been tempted to use it during the day or at work or anything (I drive for work.) The only time its a problem is if I need to be up early so a session dosen't jive with my schedule. Even after over a year (with a few breaks) I still find the experience quite magical provided I have a good soundtrack, though the hypomanic afterglow isnt there. For awhile I kind of struggled with it but now It's part of my life like music television & the internet. Entertaininment I use (almost) every day but I know I could live without it. And I know that someday I will have to.

Until then I'm going to enjoy it :) To all those having problems, I hope you can figure things out. If you cant keep up with your other responsibilities in life, that's when addiction really becomes a problem. If I had children or another situation where I couldn't fit my MXE use into my life, I could see it being a problem (and I'd have to find another addiction, or become a "normal" person. *cringe*) :p
 
Identity888 said:
I apologize for misinformation then!! I really thought it binds to all those receptors.

But what about dopamine or opioid receptors? I have read many posts regarding those with MXE. Does it really effect ONLY SERT and NMDA?

I have very minimal understanding about neuro chemistry by the way.. Sorry again.
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It only directly affects those two. Anyone saying otherwise is either guessing or wrong. Indirectly it probably affects dopamine but enough to make a difference. Don't take that last statement as fact, though; I'm just guessing (and so is everyone else on that matter).

I think MXE's addictive properties can be explained by:

1) It's a really fun drug
2) It's cheap
3) It's not hard to find high quality MXE
4) It's sold in gram amounts and shipped directly to you
5) The people who know about MXE are, for the most part, experienced drug users (meaning they're more likely to have addictive personalities)

If Ketamine was legal and sold the way MXE is people on these forums would be mad addicted to that shit too. But Ketamine doesn't directly affect dopamine, either.
 
@oar9fi ^ That is great for you! I wish I would be somehow alike to you or in similar mindset..

My situation lets me to use as much drugs as I want, as I do not have any REAL responsibilities at all. And I am still depressed :D funny and kind of sad at the same time
 
Identity888 said:
@oar9fi ^ That is great for you! I wish I would be somehow alike to you or in similar mindset..

My situation lets me to use as much drugs as I want, as I do not have any REAL responsibilities at all. And I am still depressed :D funny and kind of sad at the same time
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Having a lack of responsibilities can make you MORE depressed.
 
WSH said:
But INdirectly, ketamine certainly does affect dopamine:
http://www.ketamine.com/dopsergaba.html


I expect MXE to act in a similar indirect way.
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If ketamine increases dopamine in humans by 500%, that would mean ketamine releases more dopamine than cocaine (I've seen figures of between a 150% and 400% increase in dopamine for cocaine). Not saying that site is wrong, but they do their tests on rats. You have to remember rats react much differently to NMDA antagonists than we do, as evidenced by Olney's lesions. Common sense and experience tells me that there's no way ketamine releases anywhere near the amount of dopamine that cocaine does.
 
Effuzion said:
If ketamine increases dopamine in humans by 500%, that would mean ketamine releases more dopamine than cocaine (I've seen figures of between a 150% and 400% increase in dopamine for cocaine). Not saying that site is wrong, but they do their tests on rats. You have to remember rats react much differently to NMDA antagonists than we do, as evidenced by Olney's lesions. Common sense and experience tells me that there's no way ketamine releases anywhere near the amount of dopamine that cocaine does.
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He didn't say that it increased 500% in humans, but in animals. The ratio is more than likely not applicable to humans, but the fact it increases dopamine levels in animals means it most likely works in a similar fashion.
 
how does tolerance work on MXE?
does it depend on quality?

I've been doing around 30mg to 50mg of MXE every other day for the past few months, everything under control.

Today I dosed and didn't feel a thing... Had to redose even higher.

can you mix from differentg vendors?
 
I started doing this in August. Was looking for something to replace acid which has become hard to find. I will continue buying a lot of it-- it's a great investment.

Always doing drugs with my husband-- he's a narcoleptic, says the dreaminess of hallucinogens help him. He was the one who wanted to do acid on a weekly basis, when we had it. Recently, MXE use has escalated from more or less weekly, with occasional long breaks for whatever, to multiple times a week. This has to do in part with the weather, probably, cold has a very negative effect on fatigue of narcolepsy, and being sleepy makes him depressed, so I assume he's seeking its anti-depressant effects.

I don't crave frequent trips but when he does it I do it with him. My big addiction is the computer. My PC is where I feel comfortable, I am constantly drawn to it, which effects depression and perception of time. When the MXE trips escalated to multiple times a week, I had trouble using the PC under the influence, and outside the influence I was able to stay away from the computer for longer. In general, I appreciate drugs for this, but the repeated sessions of MXE reduce the sway of the computer indefinitely.
 
Guys, lately I've been using MXE relatively frequently (several times a week) and now a blood test returned with liver enzymes ASAT and ALAT somewhat elevated. Could this be the MXE? Hepatotoxicity would suck ass! Been using about a gram a month.
 
Asante said:
Guys, lately I've been using MXE relatively frequently (several times a week) and now a blood test returned with liver enzymes ASAT and ALAT somewhat elevated. Could this be the MXE? Hepatotoxicity would suck ass! Been using about a gram a month.
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A gram a month... that sounds like a very troubling amount indeed. I recommend no more than ~200 mg per month, maybe 300, if you're comfortable pushing it.

I don't know why, but everyone seems to have to learn to respect MXE the hard way, including me.
 
Asante said:
Guys, lately I've been using MXE relatively frequently (several times a week) and now a blood test returned with liver enzymes ASAT and ALAT somewhat elevated. Could this be the MXE? Hepatotoxicity would suck ass! Been using about a gram a month.
Click to expand...

Have you been doing anything else? Don't worry livers are remarkable at recovering, just lay off the substances for a month.
 
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