How to avoid nausea on 2C-B?

[MatttS]

I'm planning on taking 2C-B for my first time in rave environment. Some of my friends have taken it recently and haven't had any problems but I've read quite a few trip reports where people have thrown up. Obviously a rave isn't the best place to be throwing up so what can I do to prevent this?

 

[lamanogaucha]

Don't ingest 2C-B until at least three hours after your last meal. Don't drink too much. Smoke some cannabis. On the other hand, since this is your first time with 2C-B, I suggest that you experience it without any other substance in your system. Only use weed if you absolutely must, or if the trip seems too mild.

 

[2002Tii]

You can also try ginger extract and I've also heard of people using Benadryl or generic taken 20-30 minutes before you dose to help combat nausea.

If it puts your mind at ease at all 2C-B has caused me the least nausea out of the group, even at 50mg, and I tend to be prone to nausea (but not vomiting)

 

[azgaza]

Personally I've never been nauseous from 2c-b; it's not that hard on the stomach at all. I have however had two friends get sick during the peak of the experience and what helped them a lot was smoking some hash or weed.. that does help, they felt fine after and for most of the experience. Mostly though my friends also find 2c-b easy on the body and nausea is not thát common with the substance. I can even eat on 2c-b more easily then I would on LSD.

 

[Thorns Have Roses]

2c-b is very well tolerated as far as phenethylamine psychedelics go, so I wouldn't be too worried about nausea. Anyway the standard remedies apply: ginger, diphenhydramine, cannabinoids, etc.

 

[daytryptr]

5ht-3 antagonists.

Ondanserton, beta-pinene in lemon essential oil, and its also in ginger.

Works wonders for serotogenic nausea ime. And its not just mumbo jumbo, theres scientific evidence to back up the efficacy of 5ht-3 antagonists as remedy's for psychadelic induced nausea. But it can also affect the trip, since you are changing how your receptors are being hit by throwing an antagonist into the equation.

It works very well for harmalas&mescaline in my expirence though. That's a pretty nauseating combo, but much more bearable with a few drops of lemon essential oil.

 

[Thorns Have Roses]

^Ondansetron is top drawer stuff, I wish it were OTC.

Lemon essential oil is pretty cheap stuff though, right? Have you (or anyone else) found it to be a particularly efficacious anti-emetic?

 

[daytryptr]

^^ Better than ginger imho, and to a degree it definately helps, its not a panacea though. I've heard others report similar affects as well.

Never had ondanserton, but cannabis is out of the question most of the time when i'm tripping, though its pretty effective as an anti-emetic.

I've heard a few people say leo (lemon essential oil, not law enforcement officers lol) works wonders with 2c-e, and i've tried it with 2c-d, 2c-t-2, 2c-i, allylescaline, mescaline, extracted harmalas/dmt, mescaline/dmt, and a bunch of 4-subb'd trypts with pretty consistently effective results. Most of the time now i just don't need it as i don't dose as high as i used to, so nausea is pretty manageable if i have a relatively empty stomach, and wait until i'm peaking to eat something if i'm hungry.

 

[Thorns Have Roses]

cannabis is out of the question most of the time when i'm tripping

Cannabis goes great with tripping for me, but it's is out of the question most of the time in general due to living circumstances. It'd be nice to add something to the arsenal besides antihistamines/ginger, if l.e.o. helps enough to let me go out for a walk when I otherwise would be unwilling that'd be wonderful. I'll have to try it out someday.

 

[jhoppa]

MDMA is a surprisingly effective preventative for 2C-x nausea. Of course, you're looking at a very different experience and some new safety issues to consider (it's not as healthy to roll as often as it is to trip).

Ju's one anecdote: I puke pretty much every time I trip. Only LSD is free of nausea for me, and only sometimes. The one time I took 2C-I three hours into a roll was the first time I hadn't puked (or experienced any nausea to speak of) on a non-LSD trip in years and years.

Further anecdotes in the literature seem to be consistent with my experience.

 

[psood0nym]

5ht-3 antagonists.

Ondanserton, beta-pinene in lemon essential oil, and its also in ginger.

Works wonders for serotogenic nausea ime. And its not just mumbo jumbo, theres scientific evidence to back up the efficacy of 5ht-3 antagonists as remedy's for psychadelic induced nausea. But it can also affect the trip, since you are changing how your receptors are being hit by throwing an antagonist into the equation.

Ondansetron is highly selective for 5-HT3 and so, relative to other antiemetic medications with more sloppy receptor profiles the subjective effects of it should be theoretically limited. It certainly doesn't bind to 5-HT2a/1a in any significant way, and 5-HT3 agonism (vs antagonism) is associated with sensations of nausea and anxiety, and so arguably any effects selective 5-HT3 antagonists might have on the subjective qualities of a trip would be considered improvements by most. There could be "downstream" effects that manifest in unwanted subjective influences, but I've never noticed them in my limited experience combining serotonergic psychedelics with ondansetron.

It's a crime how expensive the stuff is, though, especially considering it's predominately used as an antiemetic for chemotherapy patients... <snip> We're not here to help people order from IOPs, and it was unsolicited advice at that. Let's just leave that bit off.

~Never

 

[DickTate]

As I already mentioned in the B&D 2c-b thread I experienced not only the worst nausea from any psychedelic but also a very uncomfortable bodyload on 20mg oral.
I did not throw up but it was pretty harsh so it is clearly affecting people very differently in that regard. I personally would definitely not do this at a rave or public setting. But that's just me.

Just wanted to mention this with no intention to blow your potential buzz

 

[bunnyhentman]

I refer to 2c-b as 2c-barf because although it doesn't give me a ton of discomfort, around my peak I usually have to make a sudden bathroom trip -- it's kind of "clown puking rainbows" but I would still avoid it if I could.

I have tried Meclizine (dramamine less drowsy). It really did help with the nausea/gi distress, but I also felt a little tired and it seemed to blunt my trip a bit.

 

[azgaza]

I forgot to mention; menthol also helps against nausea; calms the stomach directly though and does nothing through for example the 5ht3 receptor; still peppermint tea can calm a slightly upset stomach down when you drink it slowly in small sips. I usually have it with mushrooms since they cause me out of all psychedelics the most nausea (still mild, but often slighly distracting in the early peak; menthol makes that all go away). I would give it a try too for 2c's if anyone has stomach problems with those (I'm glad I don't )

 

[SpecialK_]

I'm prone to nausea on psychedelics and 2C-B does bring me some nausea and at most I'll be sick. But I've found the trick is to 1: Not eat too much a few hours before, but a light meal so if you need to be sick you can be, 2: Not too much alcohol - but if your like me you'll mix it anyway 3: Keep yourself focussed/doing something, if your out at a rave keep dancing, even at that hint of nausea sometimes all it takes is a bit of distraction and next thing the comeup is over and your smooth sailing.