Energy supplements with MDMA

[samnslumberland]

Can anyone give me any insight as to what taking an energy supplement such as L-Tyrosine 500 (found at your local GNC for about $10) prior to dropping MDMA would do to your high?

 

[Folley]

L-Tyrosine is a dopamine precursor I believe.. I remember reading that is it NOT good to take with MDMA, as it causes more dopamine free radicals to be around in the brain and as such, does more damage to the serotonin receptors.


They did a whole study on it here:

http://www.jneurosci.org/content/26/1/290.full.pdf

The specific mechanisms underlying ()-3,4-methylenedioxymethamphetamine (MDMA)-induced damage to 5-HT terminals are unknown. Despite the hypothesized role for dopamine (DA) and DA-derived free radicals in mediating this damage, it remains unclear why
MDMA produces long-term depletions of 5-HT in brain regions that are sparsely innervated by DA neurons. We hypothesized that the
precursor to DA biosynthesis, tyrosine, mediates MDMA-induced 5-HT depletions. Extracellular tyrosine concentrations increased
fivefold in striatum and 2.5-fold in hippocampus during the administration of neurotoxic doses of MDMA. In vitro results show that
L-tyrosine can be hydroxylated nonenzymatically to the DA precursor L-3,4-dihydroxyphenylalanine (DOPA) under pro-oxidant conditions. The local infusion of L-tyrosine into the striatum or hippocampus during MDMA administration potentiated the acute increase in
extracellular DA and the long-term depletion of 5-HT after MDMA. Coinfusion of the aromatic amino acid decarboxylase (AADC)
inhibitor m-hydroxybenzylhydrazine attenuated these effects in hippocampus and decreased basal extracellular DA in the striatum. In
contrast, the reverse dialysis of the tyrosine hydroxylase inhibitor -methyl-p-tyrosine into the hippocampus did not affect MDMAinduced increases in extracellular DA or the long-term depletion in 5-HT. These results show that MDMA increases the concentration of tyrosine in the brain to cause a long-term depletion of 5-HT via the nonenzymatic, tyrosine hydroxylase-independent, hydroxylation of tyrosine to DOPA and subsequently to DA via AADC. Overall, the findings suggest that MDMA depletes 5-HT by increasing tyrosine and its eventual conversion to DA within 5-HT terminals

 

[samnslumberland]

L-Tyrosine is a dopamine precursor I believe.. I remember reading that is it NOT good to take with MDMA, as it causes more dopamine free radicals to be around in the brain and as such, does more damage to the serotonin receptors.


They did a whole study on it here:

http://www.jneurosci.org/content/26/1/290.full.pdf

Perfect, that is exactly what I was looking for. Thank you!

 

[Folley]

If you want a good energy supplement to take with your MDMA to give you a boost of energy, drink a 5 Hour Energy.

The B Vitamins will keep your roll going longer than normal, and the caffeine, guarana and all that other shit in it will keep you up and bouncing around.

another option would be DMAA, a work out supplement that's very similar to caffeine. I've heard good things about that with MDMA too.. the 5 hour energy is probably the best though.

 

[samnslumberland]

If you want a good energy supplement to take with your MDMA to give you a boost of energy, drink a 5 Hour Energy.

The B Vitamins will keep your roll going longer than normal, and the caffeine, guarana and all that other shit in it will keep you up and bouncing around.

another option would be DMAA, a work out supplement that's very similar to caffeine. I've heard good things about that with MDMA too.. the 5 hour energy is probably the best though.

Awesome, thank you so much Folley!

 

[dcraver877]

b-vitamins sound like the safest bet. I'd imagine some good sublingual b12 (methylcobalamin or hydroxycobalamin) would really get the synapses firing. I've been considering adding ginseng or reishi to my next roll but I am hesitant as I have not seen many reports of anyone doing this.

 

[samnslumberland]

b-vitamins sound like the safest bet. I'd imagine some good sublingual b12 (methylcobalamin or hydroxycobalamin) would really get the synapses firing. I've been considering adding ginseng or reishi to my next roll but I am hesitant as I have not seen many reports of anyone doing this.

Yeah, adding substances to any drug when you're unsure of what the outcome will be is like playing Russian Roulette. Not worth it to me personally.

 

[dcraver877]

i think one of the best things you could add to mdma would be something that makes your heart not beat so hard. I've been having lots of blood pressure issues lately on molly.