Opioids Injecting vs Oral, what exactly is the difference ??

[EEhouseEE]

So in general what exactly is the diffverence between injecting an opiate and doing it orally. lets use oxycodone for example.
I know injecting is ocnsidered alot better by many people but can someone explain pretty much how injecting hits you compared to orally doin oxycodone.
Ive only ever done oral.

Does injecting really hit you that fast and does it even last long or does it go away quicker.
Do you nod more, is the high really the much better or is the "rush" the only difference.

I am not acctually planning on doing this but iam just interested to how much better IV of opiates are compared to oral.

 

[tricomb]

The difference is IV means nearly instant onset, so the duration should be shorter than oral dosing.

Oral dosing is the best way to take oxycodone, it has a near 90% bioavailability, so don't fix what ain't broke.

There's no "rush" with oxycodone taken intravenously. You do not "nod harder" by dosing oxycodone intravenously rather than an equipotent oral dose.

There are other opioids which are better taken IV than orally, but oxycodone is not one of them. IMO most people who inject oxycodone have a deeper routed addiction to the needle itself, because the reward is not worth the risks to inject a drug for a mere 10% bioavailability gain.


The rectal ROA could provide faster onset with much less risk involved, although some users report that it's not consistent (unlike the oral ROA), so once again, don't fix what ain't broke. Oxycodone is best taken orally, as directed, as it was designed and formulated.

 

[Swimmingdancer]

This can easily be found by using the search function, but the difference in effects between oral administration and intravenous administration varies hugely depending on the specific drug.

With oxycodone, different people seem to have very different results. Some say there's no rush, it comes on slowly and is really no better than oral (some people even say it's worse), and some say it hits them stronger and faster. Not sure about the difference in duration though, injecting likely wouldn't last as long as oral. Most people I've talked to say injecting oxycodone is NOT worth it especially considering the risks of injection.

Here is a thread to read:
Injecting OxyContin, is it worth it?


EDIT: ninja'd by tricomb

 

[raver2008]

Yeah oxycodone IV isnt any better. However with opiates that have low BA's orally and nasally (morphine, hydromorphine etc) IV feels like a completley different drug.

 

[EEhouseEE]

Yeah i guess this is all true with oxycodone. I hate how some people acctually snort this shit when oral is so much better.
What about smoking itt lol ? maybe thats the best?

 

[tricomb]

Smoking it is even more fail than injecting and snorting combined.

 

[jones-in_J]

Smoking it is even more fail than injecting and snorting combined.

yeah man, fuck smoking it

 

[Hiltoniano]

Snorting oxycodone is only useful when a user is attemting to get the "next best thing" as far as onset time. I used to snort it, but it was because I was uneducated about drugs in general and believed that snorting anything( save weed lol) would result in a better high. Tbh the snorting hits harder, but if you could quantify time spent high + intensity of high overall, oral wins. As far as IV, I can't speak as I have only been with people who do it,I've never shot up.

 

[tricomb]

Honestly I think "the next best thing" would be rectal.


$0.02

 

[mrflowers00]

it's bullshit that oxycodone doesn't give you a rush when IVed i get just as good of a rush from oxy as i do dilaudid or heroin

 

[SaosinEngaged]

The difference is IV means nearly instant onset, so the duration should be shorter than oral dosing.

Oral dosing is the best way to take oxycodone, it has a near 90% bioavailability, so don't fix what ain't broke.

There's no "rush" with oxycodone taken intravenously. You do not "nod harder" by dosing oxycodone intravenously rather than an equipotent oral dose.

There are other opioids which are better taken IV than orally, but oxycodone is not one of them. IMO most people who inject oxycodone have a deeper routed addiction to the needle itself, because the reward is not worth the risks to inject a drug for a mere 10% bioavailability gain.


The rectal ROA could provide faster onset with much less risk involved, although some users report that it's not consistent (unlike the oral ROA), so once again, don't fix what ain't broke. Oxycodone is best taken orally, as directed, as it was designed and formulated.

Absolutely, orally is the most efficient way to use Oxycodone.

But I've always preferred snorting it. I know people say it's a waste, but the much quicker onset and "mini-rush" you get is unbeatable. And if you don't inhale like the updraft of an EF-5 tornado, there should be very little chance of you getting filler particles down into your lungs as your moist nasal cavity and throat will absorb them.

I took Oxycodone orally for about a year, but once I tried snorting it I've never gone back. Just speaks to how everyone has different preferences. But for HR's sake sticking to the proven BA, orally is technically the best way to use it. It lasts much longer that way.

 

[ayjay]

^Actually harm reduction principles would suggest that we support people to use drugs as safely as possible, in the manner they wish. So if people choose to inject, providing safer injecting information is the most significant harm reduction information we can provide

 

[Swimmingdancer]

^True, but it's also HR to suggest other ROAs and tell them the least harmful ones / give them the reasons not to inject something, especially when they have not made up their mind to inject already. Of course if someone is going to inject regardless we should tell them the best ways to reduce harm while injecting, but it is still HR to tell someone that it's wisest to stick to oral administration.

 

[Mzral]

When I first started doing oxycodone (perc 30's), I started off eating them and it always got me good. When I had more control over my usage and only used a few times a week, just one of them would get me to where I wanted to be. I'm no novice to putting drugs up my nose but it was my girlfriend who started snorting them and from there I started doing the same thing. I went back to trying to eat them a few times and I got NOTHING out of it. It made no sense to me. The only way I could feel it was through insufflation. I thought it might have been psychological, associating snorting with getting high, but I never went into it thinking like that. After awhile I graduated back to heroin as the price for pills got out of hand and I wasn't getting the bang for my buck.

In regards to IVing oxy? I did it once or twice with a girlfriend and she claimed to get something out of it, but I just remember it putting me in a strange mood, depressed almost. Don't know what was up with that. If I were to do them again I'd probably put it up my nose.

 

[Znegative]

Shooting oxycodone like others have said is not worth it unless you need to get straight right away. However, if you're used to ROA with slower onsets, switching to IV would be kind of stupid IMO as you don't know what it is to be out of withdrawals instantly, so Id reason that its more likely that people that use opiates through other means of consumption can probably handle being sick a little bit better as you still would be in withdrawal even after you dosed. When you switch to IV use, you kind of become a baby. It brings "instant gratification" to a whole new level. The few times I've had oxycodone without APAP I shot it because I was sick and had no patience. However, there was no rush, and the high wore off within an hour. It's basically utter shit to IV IMO.

A lot of people also turn to IV because they think that they'll be able to use less of their drugs with the same intensity. While this may be true for a time for other opiates that have weak BA through every other ROA (morphine, hydromorphone, and arguably heroin even though its absorption through rectal and insufflation is high, it's still about 50% less than parental), eventually the ammount of the drug used will be the same, only you're stuck on a much more addictive, and often more dangerous ROA. It's kind of like using potentiator's but worse. The short term outcome might put you at an advantage, but within little time you'll be right back where you started, or worse.

Opiate-Analgesic Drugs that are commonly injected:

• Heroin
• Morphine
• Hydromorphone (Dilaudid)
• Oxymorphone (Opana, Numorphone)

What the above drugs also have in common is that beyond an immediate onset (like IV oxycodone), they also produce powerful rushes which make shooting more "enjoyable" of an experience. Im not sure of the exact science, but a lot of this has to do with how fast the drug penetrates the blood brain barrier.