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  • BDD Moderators: Keif’ Richards

25mg zoloft+150mg tramadol

xbloodwhipx

xbloodwhipx

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Jun 22, 2011
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If i mixed tramadol and zoloft, would i be at a high risk for seizures or serotonin syndrome considering both doses are relatively low
 
Some doctors do prescribe them together in very low doses with careful monitoring, but I would not risk it as I do know people have died from taking them together, even under their doctor's care.
 
I would caution about serotonin syndrome more than seizures, though they are not outside the realm of possibility even when taking tramadol alone. 150 mg tramadol is a decent dose, and I would not call it low. It might, for you, not produce enough o-desmethyltramadol at that dose for you to see it as larger than a low dose because that is what is responsible for the opioid feeling, BUT 150 mg tramadol is a pretty big dose as far as how much serotonin it can work with even though it might not seem it. I would definitely not take any Zoloft with the tramadol - even 25 mg of Zoloft. Even if this combo has been fine in the past, it does not mean it will be this time. They are both just too serotonergic for me to say it is safe, for I don't think it is, and I would recommend against it.
 
Long answer no with an if, short answer yes with a but...

It's not recommended. Serotonin Syndrome isn't fun and there's no way for us to know your specific body chemistry so there is a chance. Seizures I doubt would be of more concern than SS.

That said, I've mixed 20mg lexapro with 300mg dxm (DO NOT DO THIS) and never suffered from it, but my body seems to be able to take any fucked up shit I can throw at it and had I known the dangers then I wouldn't have attempted it.

So, in those small doses its not likely, but I wouldn't chance it. Especially for 150mg of tramadol which in my opinion wouldn't produce a euphoric state worthy of said risks involved.

I'd say wait at least a day or two to let the zoloft flush out. I take lexapro and one day off can let me use DXM in high doses without problems, but again, YMMV and we don't know your sensitivity to these things.

I wouldn't advise it at all. Bin the tramadol and get some codiene or kratom or something.
 
Thou said:
Long answer no with an if, short answer yes with a but...

It's not recommended. Serotonin Syndrome isn't fun and there's no way for us to know your specific body chemistry so there is a chance. Seizures I doubt would be of more concern than SS.

That said, I've mixed 20mg lexapro with 300mg dxm (DO NOT DO THIS) and never suffered from it, but my body seems to be able to take any fucked up shit I can throw at it and had I known the dangers then I wouldn't have attempted it.

So, in those small doses its not likely, but I wouldn't chance it. Especially for 150mg of tramadol which in my opinion wouldn't produce a euphoric state worthy of said risks involved.

I'd say wait at least a day or two to let the zoloft flush out. I take lexapro and one day off can let me use DXM in high doses without problems, but again, YMMV and we don't know your sensitivity to these things.

I wouldn't advise it at all. Bin the tramadol and get some codiene or kratom or something.
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Ok well its been 27 hours since my last dose of zoloft.
Im going to take it tommorow, at about 12 PM.
Hope i dont get SS, but it seems like thats enough time in between the two doses
 
xbloodwhipx said:
If i mixed tramadol and zoloft, would i be at a high risk for seizures or serotonin syndrome considering both doses are relatively low
Click to expand...

I took Effexor XR and tramadol together and ended up on life support, heart and breathing stopped numerous times, Glasgow Coma Scale so low the doctors said to my family there was practically no hope and that if I somehow did come out of the coma I would be so brain-damaged from lack of oxygen I would be a low-watt gurgler.

So yeah only take an SSRI/SNRI + tramadol if you have a death wish.

Check the "Bluelight Shrine" out to see a young bloke who died from this (he took the two, went to bed and never woke up).

It's just not worth it. :|

Personally I think taking anything that induces the release of lots of serotonin while on an SSRI/SNRI is just asking for trouble, this includes ecstacy, DXM, etc.

Please re-think your decision.

PS: I don't think 27 hours is enough time to reset your neurochemistry from an SSRI. When I came off Effexor, it took weeks (although I know Zoloft has a shorter half-life).

*EDIT: I just realized I got it mixed up, zoloft has a longer half-life. Even more reason to re-consider.
 
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Like I said some buzzes aren't worth it.

I've got a satchel full of mushrooms that look like psilocybes.

I'm going to do extensive experiments to identify them properly, even then I probably won't eat them. Perfect example.
 
AminoAcid said:
I took Effexor XR and tramadol together and ended up on life support, heart and breathing stopped numerous times, Glasgow Coma Scale so low the doctors said to my family there was practically no hope and that if I somehow did come out of the coma I would be so brain-damaged from lack of oxygen I would be a low-watt gurgler.

So yeah only take an SSRI/SNRI + tramadol if you have a death wish.

Check the "Bluelight Shrine" out to see a young bloke who died from this (he took the two, went to bed and never woke up).

It's just not worth it. :|

Personally I think taking anything that induces the release of lots of serotonin while on an SSRI/SNRI is just asking for trouble, this includes ecstacy, DXM, etc.

Please re-think your decision.

PS: I don't think 27 hours is enough time to reset your neurochemistry from an SSRI. When I came off Effexor, it took weeks (although I know Zoloft has a shorter half-life).

*EDIT: I just realized I got it mixed up, zoloft has a longer half-life. Even more reason to re-consider.
Click to expand...

I guess i have a death wish, i took them together
Thou said:
How'd it go?
Click to expand...
Fine
It went fine.
 
Just because it went fine this time, does not mean it will another or the next after that, and so on. I am with AminoAcid about how dangerous the combination is, even though it is not unheard of in the practice of medicine. It really is, though, VERY dangerous. A bit over a day without Zoloft is not sufficient to clear your system of it, for it has been dosed constantly, and although the half-life may not be terribly long as say Prozac, if there is enough in your blood it can be an issue, and a serious issue, too. An example of how half-life is not everything is how I once took 2.5 mg Xanax, a benzo with a pretty short half-life, but at that point I had no tolerance, and even though a lot of the drug was cleared, a lot was not, and there was enough for me to still feel the effect for well over a day. I am stressing - leave lots of time in between. But, I will also say, why bother going through that stopping SSRI's for days to take tramadol, just leaving your serotonin activity in havok in the end. It just doesn't make sense. If you want to remain on an SSRI, which CAN be helpful for some, fine, but I would not then advise playing with tramadol even if you have temporarily stopped taking the SSRI. A lot of danger, a lot of unhealthiness, and possibly some serious dysphoria depending. I would just not do the tramadol if you are on an SSRI. I have been there with SSRI's and other serotonergics, and it is NOT worth it. I was never harmed, thank god, but I very well could have been.
 
Alex000 said:
Just because it went fine this time, does not mean it will another or the next after that, and so on. I am with AminoAcid about how dangerous the combination is, even though it is not unheard of in the practice of medicine. It really is, though, VERY dangerous. A bit over a day without Zoloft is not sufficient to clear your system of it, for it has been dosed constantly, and although the half-life may not be terribly long as say Prozac, if there is enough in your blood it can be an issue, and a serious issue, too. An example of how half-life is not everything is how I once took 2.5 mg Xanax, a benzo with a pretty short half-life, but at that point I had no tolerance, and even though a lot of the drug was cleared, a lot was not, and there was enough for me to still feel the effect for well over a day. I am stressing - leave lots of time in between. But, I will also say, why bother going through that stopping SSRI's for days to take tramadol, just leaving your serotonin activity in havok in the end. It just doesn't make sense. If you want to remain on an SSRI, which CAN be helpful for some, fine, but I would not then advise playing with tramadol even if you have temporarily stopped taking the SSRI. A lot of danger, a lot of unhealthiness, and possibly some serious dysphoria depending. I would just not do the tramadol if you are on an SSRI. I have been there with SSRI's and other serotonergics, and it is NOT worth it. I was never harmed, thank god, but I very well could have been.
Click to expand...

I just started zoloft a week ago. Its not very built up anyway
 
definitely do NOT take zooloft and tramadol together. both are serotonergic druggs, and both of those drugs lower the seizure threshold making serotonin syndrome and seizures
 
xbloodwhipx said:
I just started zoloft a week ago. Its not very built up anyway
Click to expand...

You must still realize there is danger in ANY dosing of the Zoloft, if you are to take tramadol with it - chronic dosing CAN lead to false impressions on when it is "safe" to take a certain other drug due to the build-up, but I cannot stress enough how unsafe it is to mix the two. It is not a rarity for serotonin syndrome or drug-related (very often tramadol) seizures to occur, and it is, in fact, more common than what most think, even those very educated on the matter. Tramadol is not child's play just because it is often considered "weak" in opioid action - it is a serious-ass drug. Please, please, hear this, and be safe for your sake.
 
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