Did my last message not get approved yet? Ehh... I am an old member I rejoined to provide this extremely important information.
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I had made a very nice long post this morning but apparently it said it was up for moderator approval? And now I don't see it yet. Ok so here it is a second time because this is just so important...
So the principle is this: when you activate your G protein coupled receptors, they stimulate ATP to convert to cAMP by activating adenylate cyclase.
Imagine you take any type of drug that causes a large amount of release of endogenous "fun" neurotransmitters (i.e. serotonin, dopamine, adrenaline), these drugs include:
MDMA, 6APB, MXE (if it truly is a dopamine reuptake inhibitor), possibly even stuff like Prozac... ANYTHING that can cause the infamous "BRAIN ZAP" effect that I have seen so many people post about, and have felt myself many, many times.
Well when you overstimulate your serotonin and dopamine GPCRs, you're going to burn up all your ATP. This is just what GPCRs do. They are coupled to adenylyl cyclase to signal.
I believe the "BRAIN ZAP" (I used big letters because I hate it! lol) occurs when you have depleted your ATP levels in the brain.
I don't have any further hypotheses on this. It is all based on my personal anecdotal, extremely experienced use of psychedelics.
But I have noticed that when I take creatine malate daily to replenish my ATP supplies, the BRAIN ZAP problem is solved!!! My brain zaps are a thing of tomorrow!
That is, if you insist upon doing drugs like MDMA, 6APB, MXE and such for multiple days at a time like some of us happen to do.
And now THIS -->
SO for people posting about creatine having kidney issues: STFU!
First of all, look up some literature you science noobs:
Med Sci Sports Exerc. 1999 Aug;31(8):1108-10.
Long-term oral creatine supplementation does not impair renal function in healthy athletes.
Poortmans JR, Francaux M.
Source
Chimie Physiologique, Institut Supérieur d'Education Physique et de Kinésithérapie, Université Libre de Bruxelles, Brussels, Belgium.
[email protected]
Abstract
PURPOSE:
Oral creatine supplementation is widely used in sportsmen and women. Side effects have been postulated, but no thorough investigations have been conducted to support these assertions. It is important to know whether long-term oral creatine supplementation has any detrimental effects on kidney function in healthy population.
METHODS:
Creatinine, urea, and plasma albumin clearances have been determined in oral creatine consumers (10 months to 5 yr) and in a control group.
RESULTS:
There were no statistical differences between the control group and the creatine consumer group for plasma contents and urine excretion rates for creatinine, urea, and albumin. Clearance of these compounds did not differ between the two groups. Thus, glomerular filtration rate, tubular reabsorption, and glomerular membrane permeability were normal in both groups.
CONCLUSIONS:
Neither short-term, medium-term, nor long-term oral creatine supplements induce detrimental effects on the kidney of healthy individuals.
Ann Pharmacother. 2005 Jun;39(6):1093-6.
The effect of creatine intake on renal function.
Pline KA, Smith CL.
Source
College of Pharmacy, Ferris State University, Big Rapids, MI, USA.
Abstract
OBJECTIVE:
To examine the effect of creatine supplementation on renal function and estimates of creatinine clearance.
DATA SOURCES:
A MEDLINE search was conducted (1966-September 2004) using the key terms creatine, creatinine, kidney function tests, drug toxicity, and exercise. Relevant articles were cross-referenced to screen for additional information.
DATA SYNTHESIS:
Supplementation with creatine, an unregulated dietary substance, is increasingly common in young athletes. To date, few studies have evaluated the impact of creatine on renal function and estimates of creatinine clearance. Because creatine is converted to creatinine in the body, supplementation with large doses of creatine may falsely elevate creatinine concentrations. Five studies have reported measures of renal function after acute creatine ingestion and 4 after chronic ingestion. All of these studies were completed in young healthy populations. Following acute ingestion (4-5 days) of large amounts of creatine, creatinine concentrations increased slightly, but not to a clinically significant concentration. Creatinine is also only minimally affected by longer creatine supplementation (up to 5.6 y).
CONCLUSIONS:
Creatine supplementation minimally impacts creatinine concentrations and renal function in young healthy adults. Although creatinine concentrations may increase after long periods of creatine supplementation, the increase is extremely limited and unlikely to affect estimates of creatinine clearance and subsequent dosage adjustments. Further studies are required in the elderly and patients with renal insufficiency.
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Also one thing I left out from the original post, you should use creatine malate instead of regular creatine because the malate form is much easier to digest. Creatine itself is insoluble in water, and hard to drink for some.
The malate form is much better.
But either will still do if you are not into buying a slightly more expensive supplement... creatine malate is real cheap anyways. Regular creatine is dirt cheap... at least in my books. Just harder to get down your throat.
So that is if anyone else gets those fun brain zaps after those multi-day stimulant drug binges. . . . . . . . . . and wants to stop it!
does to the mind of a youngster; weakens their memory)