How Big Pharma Hooked America on Oxycodone

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How Big Pharma Hooked America on Legal Heroin
Vice Magazine
Posted by Kelly_Bourdet on Tuesday, Sep 18, 2012

The active ingredient behind the drug, oxycodone, isn’t new. The compound was originally synthesized in Germany in 1916. The patent on the medication had expired well before Purdue Pharma, a Stamford, Connecticut-based pharmaceutical company and the industry leader in pain medication, released it under the brand name in 1996. The genius of Purdue’s continued foray into pain-management medication – they had already produced versions of hydromorphone, oxycodone, fentanyl, codeine, and hydrocodone – was twofold. They not only created a drug from an already readily available compound, but they were able to essentially re-patent the active ingredient by introducing a time-release element. Prior to the 1990s, strong opioid medications were not routinely given for miscellaneous or chronic, moderately painful conditions; the strongest classes of drugs were often reserved for the dying. But Purdue parlayed their time-release system not only into the patent for OxyContin. They also went on a PR blitz, claiming their drug was unique because of the time-release element and implied that it was so difficult to abuse that the risk of addiction was “under 1%.”

To cement the brand’s reputation among doctors, Purdue conducted more than 40 national pain-management and speaker-training conferences at resorts in Florida, Arizona, and California between 1996 and 2001. They invited over 5,000 physicians, pharmacists, and nurses to these all-expenses-paid symposia. Many were recruited and trained for Purdue’s national speaker bureau. Purdue offered starter coupons offering a free 7-30 day trial of their medication, a practice that’s common among pharmaceutical companies for everything from skincare medicine to contraceptives. OxyContin became an instant hit among doctors, many of whom saw it as a wonder drug in the battle against the debilitating effects of chronic pain. As the good news spread sales of the drug mushroomed, rising from $40 million in 1996 to more than $1 billion in 2001, outstripping even Viagra. Meanwhile, Purdue’s campaign to extend the use of powerful narcotics to ordinary chronic ailments – for which the drug has been well documented to help – proved highly successful. By 2003, over half of the OxyContin prescriptions written in the United States were written by a primary care physician.

http://motherboard.vice.com/2012/9/18/how-big-pharma-hooked-america-on-legal-heroin

Slashdot discussion: http://science.slashdot.org/story/12/09/18/2143248/how-big-pharma-hooked-america-on-legal-heroin

This is old news but it is interesting to see the extent that Purdue went to push OC's on people. And to think, my drug education taught me to worry about the corner crack dealers!
 
They actually claimed they could only find 7 cases of documented oxycodone addiction prior to getting licensed. O rly.
 
^If used for pain alone in non-users and not abused to get high it doesn't seem low to me. Social factors can be a strong influence on addiction rates.

God there's so much wrong and missed shit in this article. Kids and young adults sometimes need pain relief too. There's a huge problem of undertreating pain worldwide, even in the US.

But at the same time Purdue is like a legal drug cartel. I think in addition to claiming it was less addictive(probably citing a study using ex-heroin/morphine addicts, who'd naturally prefer morphine or heroin, can't find it now), they also said to use it 3 times a day. This could have been an attempt to insure some would be unused and diverted.

Purdue's influence in government helped. The DEA makes quotas for CII drugs. When quotas for shit like amphetamines, barbiturates, and methaqualone were higher than they needed to be, there was a lot of diversion and abuse. They were lowered very low and abuse of them dropped off somewhat. But at the same time they started raising it for opioids, now they've replaced those older ones. Some diversion is expected, though I feel treating pain outweighs the risk of someone getting high.

For a time oxycodone was self-limiting, because it required thebaine, which is only found in small amounts in regular poppies. Even then only India poppies are a decent source, and India was limited by a treaty in how much opium they could produce. But when the high-thebaine Normans were invented, the sky(and drug laws) is the limited. IIRC Australia, France and Spain aren't part of a treaty limiting concentrate of poppy straw with thebaine. That's why oxycodone, hydrocodone and buprenorphine have become more common.

I think I might have read that some influential people were involved in getting Oxycontin approved. And that fine was a slap on the wrist compared to what Purdue made.

I swear it was planned to make a major drug of abuse. They were SO EASY to abuse. Like the way the pills were made with the binders and how concentrated it was. You could pretty much take them however you wanted. Perhaps someone read William Burroughs was a fan of oxycodone and decided that it'd make a good candidate.

RIP OG OC:(:?8(. Hopefully Purdue losses their patent battle:p.
 
Is there really anything so special about oxycodone? Can't you just throw any good opioid in there without a significant shift in efficacy (provided you formulate sufficient doses and leave the APAP out)?
 
I think many studies say just about all opioids are about as effective as morphine. But IME oxycodone has a faster onset, less sedation, less stomach aches, and less itchiness. Actually if I were given a choice between pure heroin or pure oxycodone I'd choose oxy. Can't think of one study thoroughly comparing oxycodone to morphine, must be one somewhere.
 
Is there really anything so special about oxycodone? Can't you just throw any good opioid in there without a significant shift in efficacy (provided you formulate sufficient doses and leave the APAP out)?

Oxycodone has a high oral BA, which probably makes it a better candidate than other drugs with lower oral BA.

If they had chosen a different drug, with a lower oral BA, it would have given opiate addicts a greater reason to select another ROA for abuse.
 
The Zetas, the Gulf cartel and Purdue.

I can't lie, mid '90s to to mid 2000s were a great time to be abusing pain killers. That being said I seriously fear getting old and sick with the current backlash against opoid prescriptions.

I hope all this 'hydrocodone sched II' shit is just a phase. The DEA is fucking healthcare providers and patients alike in the ass
 
the acutally hooked america on OPIATES in general, now everone who was doing oxy is just injecting heroin (I have seen H use in upper middle class white people SHOOT up in the last couple years)
 
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