knock
Bluelighter
Thanks for your comments DJ Backroll! I'm surprised it's not been pulled yet tbh...
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OD Moderators: Keif’ Richards | negrogesic
Harm Reduction ⫸Official Plugging/Rectal Administration Megathread⫷
- Thread starter PhorIndicator
- Start date
Sapphires
Greenlighter
I've always encountered a certain drug in powder forum which dissolves easily in water, a dose of 150mg is ideal every time.
However, 150mg of the same drug in crystal form barely provided only half the effects normally received. The crystals were crushed, but not into a very very fine powder, particles were still visible in the water of the syringe.
Do drugs in crystal form have a lower/slower absorbency due to the membrane having a lower area of the drug per weight to work with (and having to slowly break down the particles)? Are particles even able to be broken down at all when plugged? Would the substance being 100% dissolved make such a large difference?
However, 150mg of the same drug in crystal form barely provided only half the effects normally received. The crystals were crushed, but not into a very very fine powder, particles were still visible in the water of the syringe.
Do drugs in crystal form have a lower/slower absorbency due to the membrane having a lower area of the drug per weight to work with (and having to slowly break down the particles)? Are particles even able to be broken down at all when plugged? Would the substance being 100% dissolved make such a large difference?
knock
Bluelighter
When the drug is fully dissolved, it is in neither crystal nor powder form. It is in solution, and this is the best state for crossing the rectal membranes.
Particles can be absorbed because there is moisture up your hole. I've plugged dry powder in gelcaps before - aMT specifically - and felt good effects. But you're unlikely to achieve complete absorption that way. The best bet is to ensure your drug is completely dissolved before plugging.
ilikewater
Bluelighter
- Joined
- Mar 7, 2009
- Messages
- 83
The drug for plugging has to be water soluble right? Or no? I've seen people talking about plugging benzos, like clonazepam, which aren't water soluble so just wondering how that would work.
I was also wondering about black tar heroin. I know black tar can be plugged, obviously, but I was wondering if anyone knew about any negative side effects similar to that of IV. I've read it's really rough on your veins, so would it similarly damage your soft tissue?
I was also wondering about black tar heroin. I know black tar can be plugged, obviously, but I was wondering if anyone knew about any negative side effects similar to that of IV. I've read it's really rough on your veins, so would it similarly damage your soft tissue?
augustaB
Bluelighter
Question: is this thread the replacement for the Global Workshop thread about plugging/rectal administration?
Re previous question: the volume depends on you really. If you dissolve your drug in water it will dissolve more completely in a larger amount of water than in a smaller amount.
mdma dissolves easily in water so the volume need not be great.
All you need to do is to empty the volume of water contained in your syringe into a small glass containing your drug. Wait for it to dissolve - stirring will speed up the process.
Suck all the liquid back up in your syringe and squirt it up your backdoor.
If you don't have a syringe you can use a "lube shooter", which you can buy from adult stores. These contain about 40 ml of liquid.
I favour using a larger syringe, because if the volume of liquid is greater it can reach more of your rectum, thus improving the speed of absorption.
However this all depends on how comfortable you are with retaining liquids in your derrière.
The lying on your side business really applies to enemas (douching). Because lying on your left side allows the water in your rectum to enter your colon.
In this case the small amount of liquid involved stays in the rectum and is absorbed from the rectum.
Another advantage of using a larger amount of liquid is that a more dilute solution is less likely to provoke a reaction or harm the tissue of the rectum.
I have no experience with opiates and the solvents used, so it's possible opiate users might have a different opinion.
Re previous question: the volume depends on you really. If you dissolve your drug in water it will dissolve more completely in a larger amount of water than in a smaller amount.
mdma dissolves easily in water so the volume need not be great.
All you need to do is to empty the volume of water contained in your syringe into a small glass containing your drug. Wait for it to dissolve - stirring will speed up the process.
Suck all the liquid back up in your syringe and squirt it up your backdoor.
If you don't have a syringe you can use a "lube shooter", which you can buy from adult stores. These contain about 40 ml of liquid.
I favour using a larger syringe, because if the volume of liquid is greater it can reach more of your rectum, thus improving the speed of absorption.
However this all depends on how comfortable you are with retaining liquids in your derrière.
The lying on your side business really applies to enemas (douching). Because lying on your left side allows the water in your rectum to enter your colon.
In this case the small amount of liquid involved stays in the rectum and is absorbed from the rectum.
Another advantage of using a larger amount of liquid is that a more dilute solution is less likely to provoke a reaction or harm the tissue of the rectum.
I have no experience with opiates and the solvents used, so it's possible opiate users might have a different opinion.
tentram
Ex-Bluelighter
this thread was created before the thread you mention. i might contact the mods later when i'm a bit more sober and see if a merging of some kind could be achieved; i think i know how it could be done.
tricomb
Bluelight Crew
I'd be willing to help with that in a bit, when im back
augustaB
Bluelighter
I should point out that the thread in the Global Workshop has disappeared. No mods for Global Workshop so I'm bringing it up here.
chelseagirl
Bluelighter
I tried plugging dope once when I couldn't find a vein, just took the needle off the syringe. Laid on my stomach to do it and then waited for ten minutes before moving. Or at least it felt like ten minutes... Didn't seem to work and I wouldn't try it again cuz it seemed like a waste. If anything I might consider putting the syringe up my nose if I was in that situation again.
tricomb
Bluelight Crew
Odd. I think somehow that thread ended up here in OD. Is this that thread? The title seems identical.
Seriously??? Its clear that you are not very well informed. Rectal administration is one of the best and safest routes. Have you ever heard of Tylenol suppositories, morphine suppositories, etc??? Absortion its excellent plus gastric problems, itching etc are minimized. This is far better that, slamming your veins, filling up your lungs with smoke, tearing up your nose mucous membranes, and screwing up your stomach.
Znegative
Bluelight Crew
^yeah, honestly the only reason why someone would have such a disgusted attitude towards this ROA that I can think of would be an intense fear of homosexuality that extends to the point at which anything involving ones anus is "crossing a line".
augustaB
Bluelighter
Dear Tricomb thanks for your reply. This thread is not identical to the thread formerly in Global Workshop. I have placed a query in Global Workshop, but no reaction so far. The mods of Global Workshop cannot be contacted by PM. o
I'm slightly peeved because I made several contributions to the Global Workshop thread with clear explanations of how to go about plugging and what you need to do it.
My object has always been demystification and to provide the most straightforward explanations possible.
Regards and thanks for your trouble.
augustaB
Bluelighter
I couldn't agree more.
tentram
Ex-Bluelighter
maybe we could make it a joint effort in the workshop? i'll get at you with a pm shortly, brother
Znegative
Bluelight Crew
Okay, so I was doing research a little earlier on another thread, and came upon this article, which I found pretty damn interesting now that I've started to be won over by rectal administration (though mostly in regards to amphetamines). The thread is really about the efficacy of rectally administered Oxycodone, but there was a specific question which I will quote, that caught my eye:
"One of the major factors likely to contribute to the marked variability in rectal bioavailability of oxy- codone and morphine is variability in the placement site of the suppository in the rectum. Placement in the upper part of the rectum results in drug absorption and transportation via the portal system to the liver, whereas drug absorption in the lower part of the rectum is associated with drug uptake into the sys- temic circulation (23,24). Some studies have even shown that first-pass metabolism of rectally adminis- tered drugs exceeds that after oral dosing (25,26). Thus small variations in the placement site of the supposi- tory in the rectum may result in variable partial avoid- ance of first-pass metabolism. Other factors contribut- ing to the large interindividual variability in the rectal bioavailability of oxycodone and morphine include (i) adsorption of drug to feces, (ii) spreading of the sup- pository contents to the upper part of the rectum, (iii) poor drug release from the suppository base, (iv) poor absorption from the rectal mucosa, and/or (v) poor dissolution of oxycodone in the small volume of rectal fluid (27,28 )"
So, if I'm reading this correctly, than the placement of a drug in the upper rectum can result in partial first pass metabolism, which in turn would lead to an overall lower absorption rate? Or would the ammount that could end up being transported through the portal system to the liver be so small that it would be negligible?
"One of the major factors likely to contribute to the marked variability in rectal bioavailability of oxy- codone and morphine is variability in the placement site of the suppository in the rectum. Placement in the upper part of the rectum results in drug absorption and transportation via the portal system to the liver, whereas drug absorption in the lower part of the rectum is associated with drug uptake into the sys- temic circulation (23,24). Some studies have even shown that first-pass metabolism of rectally adminis- tered drugs exceeds that after oral dosing (25,26). Thus small variations in the placement site of the supposi- tory in the rectum may result in variable partial avoid- ance of first-pass metabolism. Other factors contribut- ing to the large interindividual variability in the rectal bioavailability of oxycodone and morphine include (i) adsorption of drug to feces, (ii) spreading of the sup- pository contents to the upper part of the rectum, (iii) poor drug release from the suppository base, (iv) poor absorption from the rectal mucosa, and/or (v) poor dissolution of oxycodone in the small volume of rectal fluid (27,28 )"
So, if I'm reading this correctly, than the placement of a drug in the upper rectum can result in partial first pass metabolism, which in turn would lead to an overall lower absorption rate? Or would the ammount that could end up being transported through the portal system to the liver be so small that it would be negligible?
Alien Drone
Greenlighter
You can only go to deep, if it comes out your mouth. Or so I've heard.
It's called probing, up in these parts.
It's called probing, up in these parts.
tricomb
Bluelight Crew
Interesting ZNeg.
I only insert mine enough to ensure that it's in the rectum and that it's not going to spill, which is probably not more than 1 inch, or a few centimeters, and slowly/steadily push the plunger.
I only insert mine enough to ensure that it's in the rectum and that it's not going to spill, which is probably not more than 1 inch, or a few centimeters, and slowly/steadily push the plunger.
chelseagirl
Bluelighter
Interesting info there, ZNegative. Thanks!
Perhaps I'll give plugging another chance next time I have some rigs with detachable needles. Although it sounds like more and more complicated of a process.
Perhaps I'll give plugging another chance next time I have some rigs with detachable needles. Although it sounds like more and more complicated of a process.