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The Big & Dandy Medication/Supplement Interaction Thread

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Mixing stimulants with Wellbutrin is contraindicated [source] (both drugs lower the seizure threshold)...so, my thought is that mixing it with MDMA would also be contraindicated.

I really think you should reconsider - I've heard stories about people mixing psychedelics with Wellbutrin and having seizures as a result.
 
But I'm on such a small dose of Wellbutrin, never had a seizure in my life, and i have benzo's to raise my siezure threshhold. And i just read a report on erowid where someone on wellbutrin did mdma and had no difference in effect/potency except it took longer to take affect.
 
I once saw a young lady have a pretty full on seizure on DMT, it was far from a fun experience for her or anyone watching. Just food for thought.
 
big bird said:
But I'm on such a small dose of Wellbutrin, never had a seizure in my life, and i have benzo's to raise my siezure threshhold. And i just read a report on erowid where someone on wellbutrin did mdma and had no difference in effect/potency except it took longer to take affect.
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These people are giving you the benefit of their thoughts and experience. Seems like it might not be what you want to read. Seems like you'll do it anyway. Best of luck.
 
It seems like you already have your mind set but, I and many others would highly reccomend against it. Seriously, just hold off for a bit instead of risking your health for a high.
 
Did and done. I took a little more of my xanax then perscribed and did one .05g dose. definatley a good experience.

however i still have 4 x .05g doses that have gone missing....along with 2 oxys....fml.


close this thread if you want...im done.
 
big bird said:
Did and done. I took a little more of my xanax then perscribed and did one .05g dose. definatley a good experience.

however i still have 4 x .05g doses that have gone missing....along with 2 oxys....fml.


close this thread if you want...im done.
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Your welcome - thanks for contributing to our collective knowledge of the subject ... :\

Don't mean to be unnecessarily abrasive but the point of these forums is not merely to suck out information and spit it out when you're finished. This is about sharing knowledge, reflecting and helping people use these substances safely - amongst many other diverse and mutually beneficial reasons that people contribute to this site. The key word being contribute. Maybe reflect upon that ...

EDIT: Apologies - bad mood today
 
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With mirtazapine it's a bit hard to say, because unlike SSRI's which dampen the effects of psychedelics, mirtazapine actually potentiates psychedelics for many, including me. The mechanism behind this is not known. For me it generally potentiated tryptamines 15-20%. But it is possible it will reduce the effects for you, but I would still dare to say that it does so less than SSRI's.

I'm not familiar with the other ones though so I can't give an answer about them.
 
Cyanoide said:
With mirtazapine it's a bit hard to say, because unlike SSRI's which dampen the effects of psychedelics, mirtazapine actually potentiates psychedelics for many, including me. The mechanism behind this is not known. For me it generally potentiated tryptamines 15-20%. But it is possible it will reduce the effects for you, but I would still dare to say that it does so less than SSRI's.

I'm not familiar with the other ones though so I can't give an answer about them.
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You got any studies? Would find it really interesting.
Triptamines did not work at all for me while on Mirtazapine, including DMT.
LSD was reduced by about 75% and more didn't really make me trip any harder.
2C's and the nBOME series were the only psychedelics that did not seem to be effected by the mirtazapine.
 
Jakeperson said:
You got any studies? Would find it really interesting.
Triptamines did not work at all for me while on Mirtazapine, including DMT.
LSD was reduced by about 75% and more didn't really make me trip any harder.
2C's and the nBOME series were the only psychedelics that did not seem to be effected by the mirtazapine.
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Unfortunately there are no studies that I'm aware of. I seriously doubt any such studies would be made or approved either. It would definitely be interesting to know what causes this reaction in some people. There are, however, enough anecdotal evidence to suggest it potentiates psychedelics for some people. The only drug it (almost) completely blocked for me was MDAI.

Also 7,5 mg escitalopram had no effects on psychedelics at all for me (it is a small dose but still).

Mirtazapine in very high doses though is extremely effective in killing just about any high. I took 60-120 mg a few times to eliminate stimulant highs, to avoid comedowns and get sleep. It totally erased all effects of the stimulants and then knocked me out. With such high doses it would most probably also kill a psychedelic trip. Mirtazapine starts blocking the release of neurotransmitters, acting like an antipsychotic drug, with very high doses. I've found it even more effective than antipsychotics like Seroquel in this regard, but I don't "kill" trips anymore and try to avoid stimulants anyway.
 
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I found it useful for sleep at almost any dose range, except going higher gave me RLS, more than 45mg was excessive. Weird that it potentates psychedelics for some and not for others. I could kill trips with it quite easily as well. Taking a dose during a 2c trip would always end it but I didnt have to increase dosages either.

MDAI worked just fine when I was on Mirtaz, just was a shit drug.
 
Trandolapril - safe with shrooms or other 5HT2a's?

If someone is taking this script, can they still trip safely on shrooms, acid or other compounds? I am not a doctor, and would be grateful for any help. Below is a bit of info on it.

Trandolapril is a prodrug that is deesterified to trandolaprilat. It is believed to exert its antihypertensive effect through the renin-angiotensin-aldosterone system. Trandolapril has a half life of about 6 hours, and trandolaprilat has a half life of about 10. Trandolaprilat has about 8 times the activity of its parent drug. Approximately 1/3 of Trandolapril and its metabolites are excreted in the urine, and about 2/3 of trandolapril and its metabolites are excreted in the feces. Serum protein binding of trandolapril is about 80%.
 
Here's from wiki: changes in blood pressure 84%, including hypotension 34%, hypertension 28%, general instability 22%. If you blood pressure is reasonable I don't see why THAT should stop you.

I can't tell if it would have any weird drug interactions.
 
Are my meds making it impossible to trip?

I'm on 10mg paxil, and a 2mg of risperdal and im gonna start depekote tomorrow, is depekote, paxil, or resperdal blocking my trips? ive been trying every other week on different shroom amounts and different batches. I DID TRIP on 2 grams of shake my head was spinning and my thoughts were racing i had to take a xanax and chill out.. and shower lol please answer about ALL my meds please thanks so much! i literally have NO trip after taking 4 grams dry and i just got off risperdal yesterday like yesterday and today were my first 2 days off it, could i trip tonight ?
 
Ssris can blunt trips, and risperadal is used to stop monster bad trips in their train wrecked tracks, and depakote, being an anticonvulsant won't make anything easier. You tripped out on weed because the cannabinoid system is not blocked by your curren cocktail. May I ask why you are prescribed these drugs, as tripping with not the greatest mental health can spark very detrimental changes. There are many opinions on the topic but mine is that you only have one mind, why risk it if there is danger.
 
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Shrooms are reported to cause fainting and if mixed with pot, the likelihood o fainting increases again. Have a sitter so that you don't fall and hurt yourself.
 
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