There are already quite a few threads on this issue, here are some:
Actually addicted to Loperamide
Loperamide withdrawal.... horrible... suggestions please!!
Loperamide Withdrawal
Try to ignore any posts saying an addiction to loperamide is impossible and just read the helpful ones
. Some people like to say lope can't be dependence causing other than maybe causing a bit of diarrhea when you quit because it doesn't cross the blood brain barrier, but that is not actually correct, lope does in fact cross the BBB, it is just usually mostly removed quite quickly. But not all of it is removed and it can vary from person to person, plus if you are taking huge doses that makes a difference, as the body can't remove it all from your brain.
Hopefully those threads can be of some help.
As for a taper, I would recommend if you are having that much trouble and you have plenty of time you try a taper of about 30% a week, that means 30% of whatever dose you are currently on, rounded to the nearest easily measurable amount. So if you are taking 144mg/day, drop it to 100mg, then a week later to 70, then 50, 35, 25, 18, 12, 8, 6, 4, 3, 2, 1, 0. That will take about 3 months or so. If you want to do it faster you could try something like: 100, 70, 50, 25, 15, 10, 6, 4, 2, 0, each week, or dropping every couple of days instead of once a week. Or if you want to do it slower you could try dropping by 20% every week. See how you feel and adjust it as you go along.
i've been on high dose loperamide daily now for a year and a half (144mg a day) and now am finding it impossible to get off not to mention the WD is somewhere between bupe and methadone. does anyone have any experience with tapering from such a prolonged high dose of loperamide and what do you recommend i do as far as how often to taper and by how much? 
i have to do this or im gonna end up dead from colon cancer more than likely so please understand this is a sincere post. thank you
