Correct dosage of MDMA for club/rave

[mark881]

On a previous thread someone mentioned a formula for bodymass for MDMA. And also that that the 1st dose is really important, and the 2nd doses need to be smaller to maintain. What is this talk about the 2nd doses releasing less serotonin and more dopamine?

I have Green Squares which I've taken before. I'm estimating 80-100mg MDMA, but prob more towards the 80mg side.

I was considering 1.5 green squares then 0.5 green square to maintain. I weight 110kilos.

I am also considering 1.25 green squares.

Got club night coming up in 2 weeks...

 

[JWills20]

Basically, its a sort of guestimation of dosages. The formula is 1.5mg/kg for the first dose and like 0.3mg/kg for the second. This means that for every kg you weigh, you take 1.5mg of MDMA and then 0.3mg, 1 hour later. The formula is useful for newbies unsure of how much to take to at least stop them from taking too much/too little. But there's many more variables to dosing than just weight; tolerance, susceptability to psychoactive substances, metabolism, etc - you get the point. Dosing is far more intrapersonal and varied between people, only experience can say what really works for you. I know that 1.5mg/kg is more than enough for me.

It's said that the first dose acts as the main serotonin releaser and I believe its down to the nature of our serotonergic system and not the MDMA itself causing the lessened second dose effects. It's related to the phrase I read from Darksidesam 'The brain is the dam, the pill is the dam-buster.' Once you've released that initial rush of serotonin from the first dose, its simply not there to be released for the second dose. You will still feel a re-dose as there is still some stores of serotonin remaining, but nowhere near that of 1 hour ago. Further re-dosing just leads to more of the stimulant effects and less of the desired effects, however, the MDMA is still binding to serotonin receptors but there isn't enough to really hit you and its causing far more damage to your brain. I've not heard of it releasing more dopamine though? It would make sense somewhat - the MDMA is still attempting to bind to lots of serotonin which isn't there and therefore overcompensates the dopaminergic action leading to a different high. Do you have a source for your dopamine comment?

 

[Folley]

I wouldn't give any thought to the "body mass formula"... weight is a very small factor in finding out how much you'll need...


I wouldn't take more than 150mg in one dose.... I'd say 125mg with a 75mg redose after an hour to be a perfect dose for just about anyone without a tolerance

 

[mark881]

I wouldn't give any thought to the "body mass formula"... weight is a very small factor in finding out how much you'll need...


I wouldn't take more than 150mg in one dose.... I'd say 125mg with a 75mg redose after an hour to be a perfect dose for just about anyone without a tolerance

Good info there guys, thanks.

What do you think of the pills I have in terms of dosage? They are rated of pillreports as High MDxx. I took 1 and I was uncontrollably dancing on the way up..although the buzz ran out kinda quick, I'd say 1h 15mins and the main buzz had disappeared. I am not sure wether I should up the dose from 1.0 to 1.25 or 1.5.

I definitely like the idea of 0.5 to re-dose...when I smashed 3 pills in a night I start getting double vision trying to stick the roach in a joint and I get a bit wasted.

 

[thizzlemonster86]

yeah, body weight is a very small factor. tolerance comes into play more than body weight for sure. just pop how ever much you think you need lol i mean within reason. you would know how much YOU need more than us. it all basically comes down to your tolerance. and yeah redosing seems pretty pointless most of the time for me. redosing usually just prolongs my afterglow by an hour and then makes me feel kinda cracked out. not really worth it. if your gonna redose, i would do it 30min after the first dose. otherwise it will be kind of a waste.

 

[Bearlove]

I wouldn't give any thought to the "body mass formula"... weight is a very small factor in finding out how much you'll need...


I wouldn't take more than 150mg in one dose.... I'd say 125mg with a 75mg redose after an hour to be a perfect dose for just about anyone without a tolerance

Pretty much this - all I would add is some users are more sensitive and may need less mgs than stated. I draw this conclusion from the amount of people who would 'Roll Balls' from one 'Pokeball' which (at the time) were tested at 90mgs of MDMA.

If your taking more than 150mgs as a starter dose then you are either built like a brick shit house or (more likely) have a tolerance due to over use.

To the OP - your first dose is so important! Find out what your 'sweet spot' is and dose accordingly - if your going to top up then you have to think what your looking to achieve.

 

[heerutosen]

125 with a 75mg booster after 1 to 1.5 hours works best for me.. Tho after a little over a year of rolling every 1-2 months i still built a little tolerance. Last roll i did 180mg with a 120mg booster after 1.5 hours (week ago). Roll was great but the same as the 120-150 i usually did.. So ive decided my last roll will be in 6 weeks and then im taking a break for 3+ months.

I still haven't had any kind of comedown or side effects thanks to my diet,exercise and pre/post load regimen, but i dont want to have to keep increasing dosage to roll hard and long enough.

You guys think 3 months should be enough for this?

 

[ebola?]

the MDMA is still attempting to bind to lots of serotonin which isn't there and therefore overcompensates the dopaminergic action leading to a different high.

This isn't correct. Regardless of how much intra-neuron serotonin is present in according vesicles, MDMA will continue to bind to serotonergic and dopaminergic (and norepinephrinergic) transporters with the same frequency. With redosing, dopaminergic effects will become comparatively stronger than serotonergic effects because there simply won't be as much serotonin to release present.
...
If you have no acquired tolerance, a 100 mg attack dose and a single 50 mg redose should be pretty good. Always did me fine.

I wouldn't give any thought to the "body mass formula"... weight is a very small factor in finding out how much you'll need...

Why would this be? Immediately after dosing, the drug ingested should be distributed throughout blood plasma throughout the body. Concentration of the drug in blood plasma should determine relatively directly concentration in the brain. The only caveat I can think of is that fatty tissue has fewer blood vessels than other tissues, so if you're big and fat, required dosage will not be as large as one would otherwise expect.

ebola

 

[JWills20]

This isn't correct. Regardless of how much intra-neuron serotonin is present in according vesicles, MDMA will continue to bind to serotonergic and dopaminergic (and norepinephrinergic) transporters with the same frequency. With redosing, dopaminergic effects will become comparatively stronger than serotonergic effects because there simply won't be as much serotonin to release present.

My comment was a guess based on the OP's dopamine comment, thanks for clearing it up.