• 💊 OTHER DRUGS 💊 Welcome Guest
    Posting Rules Bluelight Rules
    Notable Threads 1 Notable Threads 2
    Dangerous Combos Addiction Support
    Emergency Services Benzo Guide v.1
    Addiction Stories Scary Case Studies
    Biology, Pharmacology & Drugs 101
  • Select Your Topic Then Scroll Down
    Alcohol Bupe Benzos
    Cocaine Heroin Opioids
    RCs Stimulants Misc
    Harm Reduction All Topics Gabapentinoids
    Tired of your habit? Struggling to cope?
    Want to regain control or get sober?
    Visit our Recovery Support Forums

Opioids Opana IR/ER

HaZeX

HaZeX

Bluelighter
Joined
Mar 5, 2011
Messages
384
So....Over the past few years Ive been prescribed Oxy since Im always in Chronic Pain due to M.S, anyway when they made the switch to the OP 80's, those things sucked for pain...

Long story really short, My doc wouldn't switch me off the oxy no matter what I said. So I resorted to buying Opana ER 20/30/40, for about a year which helped the pain so much. Of course I used them recreationally but no matter how used my pain was always gone.

Anyway, the other day I finally got scripted Opana 10IR and 20mg ER....I know the ER is supposed come out with a tamper proof thingy like the OP's....sure hope is doesn't ruin these opanas...

I think the new ER's are supposed to be called TRF's? Anyway today when I filled the script its still the old ER's
 
I'm not sure what your question is, but if you poke around for information on Opana ER, you will find lots of stuff on here.

Two things to keep in mind:
1. Opana ER is extremely risky to snort because of the very high possibility of the user developing fatal lung complications of Silicosis.
2. Opana ER is not, to be best of my knowledge, able to be safely made into an IV solution. I know there are people who say they CAn do it, but I've never heard of a method that sounds safe.

Anyway, I'm not sure what your preferred route of administration is. And as far as I know, there is no "new" Opana ER - they spent a bucket of money developing the TimerX system and it seems pretty successful.

As for Opana IR, those are my DOC and they can be used pretty much in any method your little heart desires.
 
I didn't really have a question, just sharing my joy that I was finally Rx'ed the only thing that helped me since OC's became OP's..

Yes I know the risk of snorting ER, although I was doing it inter nasally for about a year I quit for 6 months since my wallet couldn't afford a 40mg all the time.
I dont IV, so no worries there.


But no one here heard that Opana ER is supposed to become crush resistant? The FDA approved a new formula.

http://www.biotechnologyevents.com/node/4130

"Opana® ER Complete Response

On June 23, 2011, Endo Pharmaceuticals announced that it received notification from the U.S. Food and Drug Administration (FDA) that Endo's complete response to the FDA's Jan. 7, 2011 Action Letter relating to Endo's new drug application (NDA) for a new formulation of Opana ER has been accepted. The new formulation was developed in partnership with Grunenthal GmbH and is designed to provide some resistance to certain types of product manipulation. FDA has set a Prescription Drug User Fee Act (PDUFA) date of Dec. 13, 2011."

Off-topic---NO PERSONAL DISCUSSION IN PUBLIC FORUMS, take it to PM's.
 
Last edited by a moderator:
HaZeX said:
http://www.biotechnologyevents.com/node/4130

"Opana® ER Complete Response

On June 23, 2011, Endo Pharmaceuticals announced that it received notification from the U.S. Food and Drug Administration (FDA) that Endo's complete response to the FDA's Jan. 7, 2011 Action Letter relating to Endo's new drug application (NDA) for a new formulation of Opana ER has been accepted. The new formulation was developed in partnership with Grunenthal GmbH and is designed to provide some resistance to certain types of product manipulation. FDA has set a Prescription Drug User Fee Act (PDUFA) date of Dec. 13, 2011."

Off-topic---EDIT
Click to expand...

Interesting. I wonder if it is the official Endo response to the silicosis problem looming in the future. I have been wondering about what will happen if, indeed, chronic nasal users of Opana ER develop fatal lung complications en mass. While the legal points of the situation are very murky, and public opinion tends to be very low when it comes to strangers with drug problems, it would nonetheless be a PR nightmare for any pharmaceutical company. And they could even possibly be liable for the deaths that occurred after they realized Opana was being abused via snorting, and that there was a specific ingredient in it that would cause devastating results and was not being altered.

I'm glad you stopped snorting the ERs. I had a habit with them as well, for years. I snorted 60 Opana 40mg ER pills every month for about 3 years. So far, I don't notice any lung issues, and because of chronic serious health issues, I've had a lot of x-rays, CAT scans and other imaging series in the past year, as well as being an in-patient for a few months. Nothing turned up thus far.

Don't think I know a Random Dude in NYC. Are you in NY as well? And congrats on getting what you need from your Dr. It's too bad that getting adequate pain relief is rare enough that it's something to celebrate!
 
Last edited by a moderator:
Ive had a lot of experience with the opana40 ER, ground and insufflated, never had any type of pain in my throat or nasal cavity, as the stuff mostly "gels" and you get a drip like crazy. Try small lines if you are taking them nasal. ive also known people that I.V. the opana30/40 er as well. thats not my thing though. I have not had any connection with them in about one to two months though, and i do miss them....! I wonder if this will be a smiliar conversion like that of OC to OP.

edit: i read that website

Mechanism of action: Opana ER is an extended-release oral formulation of oxymorphone indicated for the management of moderate to severe pain when a continuous, around-the-clock opioid analgesic is needed for an extended period of time. Oxymorphone is a semisynthetic derivative of morphine that interacts predominantly with the opioid mu-receptor.

Phase of Development: Filed

Event Type: Regulatory FDA: PDUFA DATE

Dates: 2011-12-13

Results: Pending
 
I also have a question about Opana, I only have experience being prescribed Opana ER. I was on MScontin and was switched to Opana ER, and all i remember is being sick with WDs for about two weeks. I do not understand why people like it so much. It has such a low (10% ) oral BA. I do not understand how someone who is legally prescribed say 30mg Opana ER every 12 hours and 10mg Opana IR every 4-6 hours and take it as directed, feels any relief when they are used to other medications like Oxycontin or Exalgo for long term relief, with Oxycodone or hydromorphone for BTP. Can someone explain why Opana is supposedly so strong? I mean I know its more potent than morphine and all that, but when it comes to the BA and an ROA of ingestion, I just do not understand how it is effective whatsoever. I mean I would much rather be on 40mg OC every 12 hours, and 15mg oxy ir every 4-6 hours than sticking with opana of any kind. but as I said, I have no experience with opana IR... It just doesnt make sense to me because of the oral BA. I can see why people would want to abuse it for sure, but for me, I am pretty much done abusing my scripts and just want them to work, and I dont understand how a medication with such a low oral BA can be so effective. And like i said with my experience, when I was switched to opana ER, I had terrible WDs for like 2 weeks.. And from what I have read, that is unnervingly common.
 
from what i know , as strong as oxymorphone is, it has a shorter half life so you may not have been taking the equated dose to your mscontin which may or may not have a longer half-life (i do not know). also don't understimate the power and the will of the people to get high. most people don't munch them because of the 10% oral BA so they take to other ROAs.
 
Very true. Once I switched and realized I was going through mad withdrawals, I went to the Opana website, and used their own conversion. and I typed in that I was on 200mg mscontin a day, and it said to be taking a total of 60mg of Opana per day to be relatively close. And I was prescribed 30mg bid. and was still going through hell, I even checked another source and it too said switching from 200mscontin every 24 hours should be 60mg of opana er every 24 hours, and thats without that whole incomplete cross tolerance BS. Im just in a bind right now, because the doc I currently have is hesitant to prescribe someone my age Oxycontin, even though I have been on it plenty before, and with good reason, he is STILL hesitant. And I have an allergy to morphin sulfate, so mscontin is out of the question, trans dermal patches of any sort do not seem to work, so fentanyl patches are out, and I do not wish to go back on Opana ER again, because of the low BA, the fact that I would be taking it orally, and the price. And he also does not like to prescribe exalgo. so what does that leave? I only know of MS contin, Oxycontin, Fent patches, opana, and exalgo for longer term pain relief. He knows fent doesnt work, he knows Im allergic to msconting to a degree, and he knows opana ER does not work well for me (he prescribed all of those). so all that I know of that is left is oxycontin, and exalgo. and He is VERY anti Hydromorphone. Is there another contin type medicine that I missed? if not, he will have to choose between putting me back on oxycontin, or exalgo. And from what Ive heard exalgo doesnt really work because its a 24 hours med, hydromorph has a low BA orally as well, and I think the max dose of Exalgo is like 16mg pills. And I dont see how there are people that take 8mg dilaudid every 4 hours for a daily total of 32mg, would be sufficient on a slow release of half that daily dose. I know a lot about opiates, but when it comes to dosages, BA, and time release, I am rather naive. Sorry I went off topic. But yea, does anyone know of any sites that have more specific information on how these types of pain killers like opana ER and IR are supposed to compete with the likes of oxycontin and oxycodone which are not only higher doses, but have a much higher oral BA.
 
And just one thing to keep in mind when discussing the oral bioavailability. It is true certainly that oxymorphone has a low BA taken orally. Many many drugs do, not just opioids. But to be clear, for all the young or new-to-drugs readers out there and people looking into Opana, that is taken into account by the drug companies in creating dosages, and by doctors in prescribing. So while, yes, it's easy to see taking an Opana 10mg IR pill orally as a "waste" because you might only get the benefit of 1mg of actual oxymorphone, that IS the dose intended. I know that seems incredibly obvious, but I worry that inexperienced users might not quite understand that they aren't meant to be absorbing the entire 10mg...there are ways to increase the bioavailability certainly, but those increases are making the potency higher than intended.
 
does anyone know if the 20mg opanas are the old or new formula....... thanx 4 tha help !!!!
 
holy thread bump batman!

All Opana ER's are now "Abuse proof"

If they are 8 sided, stop signs, you may proceed to grind and snort.
 
80mg said:
The best way to use the new opanas recrationally is as follows:

1 - Take pills out
2 - Stare at them and cry.
Click to expand...

QFT!...Ive been cutting mine with a razor, they cut real easy into little pieces, then just been using them SL. After about an hour I swallow. I feel its comparable to snorting 1mg..LOL
 
You must log in or register to reply here.
Top