took 100 mg + dexedrine er and don't feel anything.

[Ms.Martini]

i do online courses, so usually when i want to get some homework done i take a high dose of dexedrine, and stay up for two days working straight. i usually take 30 mg of dexedrine er 2-3 a week before work or something, so tolerance isn't it at all. i mean, it would work before. i'm currently taking pristiq 100 mg, and sometimes 25 mg of methoprazine for sleep. i'm aware that sometimes when taking anti psychotics or something, dexedrine doesn't really work. but i haven't taken it in 4 days now, so it shouldn't be a problem. WHY DON'T I FEEL ANYTHING, THIS SUCKS. and it's a waste of pills. i've tried snorting some, or taking dexedrine 5 mg irs with it. still nothing.

 

[ErgicMergic]

How long have you been awake? The brain needs catecholamine neurotransmitters to release and play with to actually feel something off of amps, therapeutically or recreationally. On that same note, when has your last protein-rich meal been ingested?

If 30mg Dex usually works, what prompted you to take 100mg? Just curious... did you keep popping spansules as the previous ones didn't work? I would get at least four hours of sleep, crush the beads from 20-30mg Dexedrine, and eat them, following it 10 minutes later with a fat breakfast with 30-40g of protein at least.

Snorting it is a waste in terms of BA, sublingual or rectal administration is far more efficient.

I can't imagine eating 100+ Dex ER with Dex IR on the side and not feel anything, that's incredible... usually 15mg Dex with 12.5mg ephedrine dosed over 10 hours is enough for me to focus properly, but not enough to give me artificial motivation or procrastination removal, which are the wrong things to look for from amps tbh. Perhaps you are seeking the wrong thing from amps, especially smooth CNS specific ones like Dex? Start off with 20mg Dex crushed orally, imo, and chase it with 60mg caffeine (no more than this) if you can handle caffeine.

Caffeine is far better for "getting shit done" than amphetamines, but it comes with nasty cardio/GI side effects if you can't handle it.

 

[Ms.Martini]

30 mg dex don't do much, but it gives me the energy to get up in the mornings. and makes the time go faster at work. but like, i know what 100+ dex er feels like. the weird ringing in your ears. the weird feelings in your nerves and the back of your head. blacking out for a split second when you get up. it feels nothing like that. i didn't keep popping them, i took them all at once. and i took that much because i can't feel a damn thing! usually 60 mg is enough for a homework binge, but goddamnit. it has to be the meds i'm in.

dexedrine or any adhd meds use to work like a charm when i wanted to get shit done. seriously, caffeine doesn't do shit. so weird. the only thing i notice dex does for me is insomnia and makes me talk faster, probably makes me a bit manic too. BUT I USE TO GET THE DESIRED EFFECTS. i just don't know what the hell happened.

 

[lcrlover]

I have noticed over the years that at times I will no longer get the effect(s) I was trying for when I take something,
I have found that for me, that no longer working problem just means it is time for me to try something else. Ever try those 5hr energys?

 

[bluedolphin]

You obviously do have a tolerance if 30mg dexamphetamine will do little more than help you wake up, and now you are not feeling anything (which I seriously doubt you aren't feeling *anything*) from 100mg of dexamphetamine.

Like others have said, lay off the amps for a while, and switch to coffee. If amphs aren't working for you anymore, why bother?

I used to take amphetamines quite regularly but there was never a point where 30mg dex would do little more than help me wake up and 100mg would have little more effect. You have an amphetamine problem. Do something about it.

 

[Ms.Martini]

lol no i don't... i'm not addicted to them or anything, i only take them to get stuff done, not for the buzz. i have adhd, and monthly prescription to them. but i only take them as needed. okay, i GUESS i feel slightly more focused, but not motivated and shit as i should. yeah, maybe i do have a tolerance if 30 mg isn't doing much, but that doesn't mean 100 mg wouldn't do anything.

 

[ErgicMergic]

i GUESS i feel slightly more focused, but not motivated and shit as i should

This is your problem right here, amphetamines aren't supposed to increase motivation, that's just a "honeymoon" effect of a low tolerance, or a side effect of amphetamine abuse due to overly high prefrontal cortex DA levels.

Chasing the motivation from amps is like chasing the nod from opiates, it's a honeymoon effect that goes away very quickly, and needs increasingly higher and higher doses to be achieved. People who can't nod off of oxycodone anymore switch to Dilaudid, H, or Opana, even though the medicinal purpose of their opioids, analgesia, remains on oxy.

People who chase the motivation from amps tend to move to higher and higher dosages of Adderall/Dexedrine and try snorting or plugging, further raising their tolerance, then try snorting methamphetamine, then smoking it, then injecting, etc. Your brain catches up quickly with tolerance, it's unavoidable.

Use amphetamines for their intended purpose: focus. The rest is up to you.

 

[Ms.Martini]

People who chase the motivation from amps tend to move to higher and higher dosages of Adderall/Dexedrine

which is why i took a higher dose than usual. but okay, got it.
lol, trust me on the opiates though, i know all about chasing a nod. had to start banging my opiates because my tolerance was through the roof.

 

[Ms.Martini]

oh my fuckin jesus. the crash was terrible. and i had to work. puked my guts out. not that i'm complaining, shit happens.

 

[starkid]

OK, I have the same problem. I took 15mg of Dexedrine (spaced over an hour and a half) and do not feel anything at all. Years ago I definitely would feel something from 5mg. I was put on Invega sustena, a long-acting anti-psychotic, and I think it's because of that. Even though it's been 4-5 months since my last injection (it should have worn off completely by now) I think that it had some sort of potentially permanent effect on my brain and the whole dopaminergic system that's now resulting in dexedrine being completely ineffective. Very disappointed about this and don't know what to do. If anyone knows how to fix this please let me know!

 

[Swimmingdancer]

Hi starkid, welcome to Bluelight

I know this thread is less than 2 months old, but generally it's best to start your own thread unless there is already a currently active one on the exact same topic. BDD is a fast-moving forum and you will get more answers that way, as when you bump an old thread a lot of people just look at the original post in the thread, or see that it has a number of replies already and assume it has already been answered.

I believe the effects of the Invega (paliperidone palmitate) injection should have worn off within around 6 weeks or so, but it could be possible that it has had some longer-lasting effects for you. How long were you taking it for? Some long-lasting or permanent side effects are more likely the longer one has been taking it. It's not really understood how Invega works, but it is a dopamine antagonist. Are you currently on any other medications? Unfortunately I have no idea for a solution to your problem, other than perhaps trying a higher dose but I don't recommend that. I would just give up on it, unless you are legitimately prescribed the Dexedrine for ADHD or something - in which case talk to your doctor.

Did you feel absolutely nothing from the Dexedrine or did you just mean you didn't feel any euphoria?

 

[starkid]

Hi starkid, welcome to Bluelight

Thanks!

I know this thread is less than 2 months old, but generally it's best to start your own thread unless there is already a currently active one on the exact same topic. BDD is a fast-moving forum and you will get more answers that way, as when you bump an old thread a lot of people just look at the original post in the thread, or see that it has a number of replies already and assume it has already been answered.

Thanks, though I wanted to reply to this existing thread because I thought it might help the OP and since I'm also experiencing the same problem as OP, keep the discussion to one thread. Might be useful for Googlers on the topic.

I believe the effects of the Invega (paliperidone palmitate) injection should have worn off within around 6 weeks or so, but it could be possible that it has had some longer-lasting effects for you.

I found out that the half-life is 25-49 days, so right now, after about 5 months and given the worst-case half-life I would have about 12% remaining in my system, with a half-life of 30 days then only ~3%, so I'm guessing based on my experience with dexedrine so far, I probably have more than 3%...

How long were you taking it for? Some long-lasting or permanent side effects are more likely the longer one has been taking it.

Kindof an odd question because Invega Sustenna is given as an injection, and I was given 2 injections, about a week apart. It's now been about 5 months since my last injection. I feel like for my weight they gave me way too much (though IMO any amount is too much).

Did you feel absolutely nothing from the Dexedrine or did you just mean you didn't feel any euphoria?

I felt absolutely nothing, ended up taking 25mg total, and *maybe* it did something, but it was way too subtle to really tell. Just a warning to anyone with ADHD, stay away from antipsychotics, especially Invega Sustenna.

 

[Swimmingdancer]

Thanks, though I wanted to reply to this existing thread because I thought it might help the OP and since I'm also experiencing the same problem as OP, keep the discussion to one thread. Might be useful for Googlers on the topic.

Yep, that's fine. It's not very old so it's ok but usually Basic Drug Discussion is more of a quick question and answer forum and I just wanted to let you know that you might get more replies with a new thread

I'm kind wondering if maybe this should be moved to Other Drugs?

I found out that the half-life is 25-49 days, so right now, after about 5 months and given the worst-case half-life I would have about 12% remaining in my system, with a half-life of 30 days then only ~3%, so I'm guessing based on my experience with dexedrine so far, I probably have more than 3%...

Yeah, that's what I meant about the effects lasting for around 6 wks or so, but it definitely takes a lot longer for it to be completely out of your system and half-lives are just an average, your individual metabolism could vary.

If Dexedrine worked well for you before you had the Invega injections then you might be right in suspecting that it is something to do with that. Some people do even have long-term brain effects from Invega even after it's out of their system.

Sorry I can't be of much more help

 

[niddynid]

OK, I have the same problem. I took 15mg of Dexedrine (spaced over an hour and a half) and do not feel anything at all. Years ago I definitely would feel something from 5mg. I was put on Invega sustena, a long-acting anti-psychotic, and I think it's because of that. Even though it's been 4-5 months since my last injection (it should have worn off completely by now) I think that it had some sort of potentially permanent effect on my brain and the whole dopaminergic system that's now resulting in dexedrine being completely ineffective. Very disappointed about this and don't know what to do. If anyone knows how to fix this please let me know!

A dopamine antagonist would definitely explain why 100 mg of d-amphetamine barely had an effect on you.

Another factor to consider would be cross-tolerance. Do you use any other amphetamines? (ex. Methamphetamine etc.) Someone I know, is prescribed Dexedrine XR 15mg BID, and after a few weeks of smoking Methamphetamine, could easily crush & down 75 mg of dexedrine and only slightly feel the effects. Before, 15 mg was easily enough to get him spun.


About 10 or so years ago, a friend of mine had a similar experience with MDMA and an SSRI anti-depressant. He had an amount of MDMA (uncut crystal form) which He had sampled several times (same stuff) before He started taking the anti-depressant; Quality was about as good as it possibly gets. After being on anti-depressants for about a month, He took some MDMA (same stuff, usual dosage @ about 120 mg), and it did nothing, except give Him a headache and make Him feel speedy (in a bad way). So He ended up taking 3 x this amount, and the headache (and bad speediness) intensified. His friends had the same stuff, and were completely wrecked and enjoying themselves. After some research, He figured out that taking MDMA (as well as many other drugs that rely on serotonin for effect) on SSRI's is a waste of money. Essentially, he had to wait until all of the drugs were entirely gone from his system to feel the proper effects of other drugs.

One has to be careful of which drugs they choose to put in their bodies, especially those with long half lives (Invega). Drugs with extremely long half-lives (or drugs taken regularly) can cause the brain to adapt by altering neural pathways, and therefore function (neural plasticity) ; for better or worse.