iconoclast56
Bluelighter
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- Feb 4, 2012
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- 94
Fun isn't the only reason people use drugs. I wonder why it makes it impossible to have fun though. I suspect its the dopamine antagonism.
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BDD Moderators: Keif’ Richards
Seroquel - Highly Underrated
- Thread starter blight12
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Fun isn't the only reason people use drugs. I wonder why it makes it impossible to have fun though. I suspect its the dopamine antagonism.
Fox Grove
Greenlighter
I take it, it's not fun. But it does put me right to sleep, and for about 30 minutes, its euphoric. I've never experienced any bad side affects. I take 50mg and get a good 8-9 hours of quality sleep.
BabyGurl3171
Bluelighter
Lol!!! Care to tell my psych I'm obviously psycho? Maybe I'd get better meds than I have now!
I still stick with my story, my hand to God, the first time I.tried it I took the full 900 mgs and it was a fun trip. I felt great for once in a loooong time. I have tried to re-create it to no avail. Now I just stick to my 300 mg at night.
Escapedysphoria
Ex-Bluelighter
Seroquel more so than mirtazapine, is most helpful for coming down from LSD in my expirience. I also use smaller dosages of seroquel to catch sleep during opi withdrawals or also come downs from cocaine. Out of all antipsychotics, I will only use Seroquel to comedown due to it's potential to have more sedation and less antipsychotic properties. "Seroquel is very antihistaminergic—so it causes a lot of sedation. It is moderately an alpha1 blocker—which is what causes orthostasis (lightheadedness/dizziness/grogginess). And much less of a D2 blocker, which is what actually provides the antipsychotic effect." Thelastpsychiatrist.com (got it from link from provided by a poster above me if you didn't read it).
FnX
Bluelighter
- Joined
- Apr 8, 2009
- Messages
- 749
The thing is, low dose Seroquel acts mostly on the histamine receptors (that's why it makes you sleepy too). You need to up the dose for it to start antagonizing your serotoning receptors, and up it even more for significant dopamine antagonism to start taking place. There is no such thing as low dose anti-psychotic treatment with seroquel, they raise your dosage to 300mg+ asap instead. That's probably the reason many doctors feel so comfortable prescribing ~25mg of seroquel to non-psychotic patients as a sleeping aid. This is pretty basic stuff and it should be on wikipedia too.
EDIT: http://en.wikipedia.org/wiki/Quetiapine#Pharmacology (check pharmacology and/or dosage sections)
rocknroll702
Bluelighter
the only people i ever know to have mentioned or have seroquel were hard core meth addicts they did meth all day everyday and then it seemed when they were out all id hear about is seroquel lol - so weird
somewherehappy
Greenlighter
- Joined
- Feb 21, 2012
- Messages
- 22
Antipsychotics (which Seroquel is) are dangerous and brain damaging.
I think Seroquel is over rated. So many people rave about it yet I see them go downhill after taking it for years. They wonder why, maybe they developed a new physical/mental illness or that theirs is getting worse on it's own, maybe it's other meds/drugs they are using, or they are getting older so can't think as well? Or maybe it's the antipsychotics..![:\](https://bluelight.org/xf/BL_Images/Orig_Emoji/wrygrin.gif "wry grin :\")
People often forget that Seroquel is an antipsychotic, since it's so widely used off label. However this is what it is, claims that is is milder and has less effects than older antipsychotics are wrong. (it's been demonstrated to be wrong in lawsuits against the drug companies for hundreds of millions of dollars being awarded to victims being misled that it's better than older ones)
Antipsychotics cause the frontal lobe of your brain (personality, intelligence, ability to problem solve, take care of yourself, self preservation, creativity and other important things) to atrophy (tissue dies) over long term use. This has been well documented in studies and is irreversible. I've seriously suffered some damage from taking them unknowing about the side effects. I've also seen intelligent people after about 10 years of being on them become literally retarted. Unable to speak properly, huge loss of intelligence, can't take care of themselves anymore (wash themselves, pay bills etc) and end up having to live in institutions the rest of their lives.
It also causes tardive dyskinesia, tardive akithisia, tardive amnesia and tardive dystonia. Tardive Dyskinesia is disfiguring movements out of your control that are repetitive and this has no cure. Like sticking your tongue out over and over, squishing your facial muscles, swinging your arms, thrusting hips, puckering lips, opening mouth etc. Tardive Akithisia is unable to sit still and relax without inner turmoil and being severely uncomfortable to the point some patients suffering it committed suicide. Tardive dystonia is painful muscle contractions that sometimes never stop, it has left people unable to walk, unable to swallow water properly, have their back bent in a strange way such as face looking up at sky and never goes back to normal, etc. Tardive amnesia ranges from inability to remember recent things, chronic forgetfullness, or total memory loss.
They also cause drug induced parkinsons in some cases, which though is reversible upon withdrawal, the withdrawal of antipsychotics is really awful, in long term use, people have described it as worse than heroin.
It also can cause psychosis and development of 'schizophrenia' after very long term use, these symptoms will also emerge upon withdrawal for some individuals making it even more difficult to get off and having psychiatrists often uneducated about the withdrawal claim you've suddenly developed a disease and need to stay on.
I'm letting you know this because I know for a fact the vast majority of drs or psychiatrists neglect to tell patients any of this or some drs actually don't know because they aren't knowledgable about these medications. Unfortunately there is the other group that don't care and have ties to pharmaceutical companies. I've asked a dr before and had them lie to my face about a side effect. I printed up studies, other drs and tons of evidence they finally said it's true but that it's rare.
Well they all will happen but it's a matter of when, the longer your on the medication the more likely.
Sometimes you can experience this but they can go away however if you have the real tardive ones it won't. Tardive means delayed and is permanent conditions all of which have no cures and poor treatment options.
Seroquel especially (but all of them do) has a high chance to cuase diabetes and weight gain. (other lawsuits about this were won against the drug company for attempting to lie about this side effect at first, now it has to be put on the black box warning)
It's also important to note in new studies, taking antipsychotics long term lowers life expectancy signifigantly.
There's many other NASTY effects of antipsychotics which haven't been mentioned.
Resources:
www.breggin.com
http://www.nature.com/npp/journal/v30/n9/full/1300710a.html
http://www.ahrp.org/risks/biblio0100.php
http://www.psychminded.co.uk/news/news2008/April08/Antipsychotic_medication002.htm
http://www.neuroleptic-awareness.co.uk/?Neuroleptic_Physical_Side_Effects
http://www.neuroleptic-awareness.co.uk/?Neuroleptic_Psychological_Side_Effects
Please be careful before taking anti psychotics so casually!!!
I think Seroquel is over rated. So many people rave about it yet I see them go downhill after taking it for years. They wonder why, maybe they developed a new physical/mental illness or that theirs is getting worse on it's own, maybe it's other meds/drugs they are using, or they are getting older so can't think as well? Or maybe it's the antipsychotics..
People often forget that Seroquel is an antipsychotic, since it's so widely used off label. However this is what it is, claims that is is milder and has less effects than older antipsychotics are wrong. (it's been demonstrated to be wrong in lawsuits against the drug companies for hundreds of millions of dollars being awarded to victims being misled that it's better than older ones)
Antipsychotics cause the frontal lobe of your brain (personality, intelligence, ability to problem solve, take care of yourself, self preservation, creativity and other important things) to atrophy (tissue dies) over long term use. This has been well documented in studies and is irreversible. I've seriously suffered some damage from taking them unknowing about the side effects. I've also seen intelligent people after about 10 years of being on them become literally retarted. Unable to speak properly, huge loss of intelligence, can't take care of themselves anymore (wash themselves, pay bills etc) and end up having to live in institutions the rest of their lives.
It also causes tardive dyskinesia, tardive akithisia, tardive amnesia and tardive dystonia. Tardive Dyskinesia is disfiguring movements out of your control that are repetitive and this has no cure. Like sticking your tongue out over and over, squishing your facial muscles, swinging your arms, thrusting hips, puckering lips, opening mouth etc. Tardive Akithisia is unable to sit still and relax without inner turmoil and being severely uncomfortable to the point some patients suffering it committed suicide. Tardive dystonia is painful muscle contractions that sometimes never stop, it has left people unable to walk, unable to swallow water properly, have their back bent in a strange way such as face looking up at sky and never goes back to normal, etc. Tardive amnesia ranges from inability to remember recent things, chronic forgetfullness, or total memory loss.
They also cause drug induced parkinsons in some cases, which though is reversible upon withdrawal, the withdrawal of antipsychotics is really awful, in long term use, people have described it as worse than heroin.
It also can cause psychosis and development of 'schizophrenia' after very long term use, these symptoms will also emerge upon withdrawal for some individuals making it even more difficult to get off and having psychiatrists often uneducated about the withdrawal claim you've suddenly developed a disease and need to stay on.
I'm letting you know this because I know for a fact the vast majority of drs or psychiatrists neglect to tell patients any of this or some drs actually don't know because they aren't knowledgable about these medications. Unfortunately there is the other group that don't care and have ties to pharmaceutical companies. I've asked a dr before and had them lie to my face about a side effect. I printed up studies, other drs and tons of evidence they finally said it's true but that it's rare.
Well they all will happen but it's a matter of when, the longer your on the medication the more likely.
Sometimes you can experience this but they can go away however if you have the real tardive ones it won't. Tardive means delayed and is permanent conditions all of which have no cures and poor treatment options.
Seroquel especially (but all of them do) has a high chance to cuase diabetes and weight gain. (other lawsuits about this were won against the drug company for attempting to lie about this side effect at first, now it has to be put on the black box warning)
It's also important to note in new studies, taking antipsychotics long term lowers life expectancy signifigantly.
There's many other NASTY effects of antipsychotics which haven't been mentioned.
Resources:
www.breggin.com
http://www.nature.com/npp/journal/v30/n9/full/1300710a.html
http://www.ahrp.org/risks/biblio0100.php
http://www.psychminded.co.uk/news/news2008/April08/Antipsychotic_medication002.htm
http://www.neuroleptic-awareness.co.uk/?Neuroleptic_Physical_Side_Effects
http://www.neuroleptic-awareness.co.uk/?Neuroleptic_Psychological_Side_Effects
Please be careful before taking anti psychotics so casually!!!
Last edited:
^ thank you for this informative post.
Antipsychotics are sometimes necessary - to treat psychosis and other schizophrenia-related illnesses - but I agree entirely that they are not something to be taken lightly (careful weighing up of risks vs benefits is needed) and thank you very much for providing those links
Antipsychotics are sometimes necessary - to treat psychosis and other schizophrenia-related illnesses - but I agree entirely that they are not something to be taken lightly (careful weighing up of risks vs benefits is needed) and thank you very much for providing those links
Psychonauticunt
Bluelighter
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- Jun 1, 2010
- Messages
- 1,415
I only take it when I really, desperately need to end a trip or get to sleep right now and have nothing else on hand to do the same job. It shuts me right down quite quickly - hits you like a sledgehammer and knocks you the fuck out - but even with small doses I feel groggy and stupid the next day.
It feels like a nasty drug, it seems like a nasty drug from what I've read about it, so I usually stay away from the stuff.
It feels like a nasty drug, it seems like a nasty drug from what I've read about it, so I usually stay away from the stuff.
Wulfenstein311
Greenlighter
- Joined
- Mar 3, 2012
- Messages
- 2
IMO Seroquel is a horrible horrible drug with horrible horrible side effects.........
Last week after being on 80 mg of vyvanse for around 7 hours, I plugged a 25 mg adderall xr to give a little boost. Stupid;y, I grabbed the wrong oral syringe.. one I had been using to dose large amounts of 25i-nbome.
I didn't realize this till after the psychedelic effects started coming on around an hour or so in. Realizing my screw-up, I decided to wait it out, but the effects only grew stronger- after about 3 hours, with the amphetamines mostly worn off and needing to have my wits about me for a social event, I decided to take a small amount of seroquel (15 mg) for the first time to help dampen the effects of the 25i-nbome, as I have read that it works well to end trips. (note that I had not really ingested that big of a dose of 25i-nbome, it subjectively felt like around 400-450 micrograms)
This was a stupid idea on my part- what followed was around 3 hours of a light-headedness, overall feeling of shittyness, and a pounding heart with a noticeable feeling of cardiotoxicity. I was unable to sleep all that night, and the next day consisted of the worst drug-induced after effects I have ever had the misfortune to experience, with a complete lack of energy or motivation, and a ridiculous inability to control my emotions- i basically felt like a zombie that had gotten punched in the balls repeatedly for a couple of hours, while simultaneously running a marathon on a treadmill without food or drink.
I noticed slightly the same cardiotoxic feel today just drinking a redbull, very concerning, which is leading me to lay off stimulants for a long while to let my body heal from my stupid mistake.
Last week after being on 80 mg of vyvanse for around 7 hours, I plugged a 25 mg adderall xr to give a little boost. Stupid;y, I grabbed the wrong oral syringe.. one I had been using to dose large amounts of 25i-nbome.
I didn't realize this till after the psychedelic effects started coming on around an hour or so in. Realizing my screw-up, I decided to wait it out, but the effects only grew stronger- after about 3 hours, with the amphetamines mostly worn off and needing to have my wits about me for a social event, I decided to take a small amount of seroquel (15 mg) for the first time to help dampen the effects of the 25i-nbome, as I have read that it works well to end trips. (note that I had not really ingested that big of a dose of 25i-nbome, it subjectively felt like around 400-450 micrograms)
This was a stupid idea on my part- what followed was around 3 hours of a light-headedness, overall feeling of shittyness, and a pounding heart with a noticeable feeling of cardiotoxicity. I was unable to sleep all that night, and the next day consisted of the worst drug-induced after effects I have ever had the misfortune to experience, with a complete lack of energy or motivation, and a ridiculous inability to control my emotions- i basically felt like a zombie that had gotten punched in the balls repeatedly for a couple of hours, while simultaneously running a marathon on a treadmill without food or drink.
I noticed slightly the same cardiotoxic feel today just drinking a redbull, very concerning, which is leading me to lay off stimulants for a long while to let my body heal from my stupid mistake.
BabyGurl3171
Bluelighter
Hmm, of course I was never told of the intelligence issues with Seroquel...
I'm very intelligent, not bein arrogant, but I need to remain that way as I'm a programmer.
And my 9 yr old, straight A's, honor roll, student of the month, takes 400 mgs of this daily!
I'm very intelligent, not bein arrogant, but I need to remain that way as I'm a programmer.
And my 9 yr old, straight A's, honor roll, student of the month, takes 400 mgs of this daily!
Psychedelic Jay
Bluelighter
Oh you will notice the swift change in your child... It will go from her doing it for herself, to doing it for you, to completely not giving a fuck about school. You will notice her developing social life start to dwindle because of the drug making people dislike everything trying to communicate with them.
Mere life will eventually become irritating, due to a vast amplification of the drugs effects mimicking the "negative" effects of schizophrenia...
Nucynta_80
Bluelighter
- Joined
- Mar 4, 2012
- Messages
- 59
IMHO, I don't see an issue with 25mgs or 50mgs of Seroquel at night. It is true that at doses of 50mgs or less, it is mostly an antihistimine with moderate anti-chlorgenic affects. From my understanding, it still does effect dopamine, but only mildly. If you are taking for example 300 mgs a day though, then yes its going to become an issue because its having a stronger affect on your dopamine receptors and thus your ability to experience pleasure, along with the high risks for motion related disorders.
If you are having trouble sleeping, it would seem to make sense to talk to your doctor about combining a low dose of benzo (say 5mg valium) along with 25mg seroquel, vs using higher amoints of seroquel on its own. Just like most drugs, its safe at certain doses and dangerous at others.
If you are having trouble sleeping, it would seem to make sense to talk to your doctor about combining a low dose of benzo (say 5mg valium) along with 25mg seroquel, vs using higher amoints of seroquel on its own. Just like most drugs, its safe at certain doses and dangerous at others.
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