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How exactly does alcohol get potentiated by SSRI/SNRI

MikeRWK

MikeRWK

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Jan 8, 2012
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Fuck You, thats why!
Maybe i worded the title wrong but how exactly do you get completely fucked sometimes when you drink while on SSRI/SNRI? I'm guessing it happens in the liver?

I know its not smart to drink on these, i dont get drunk anymore because its not worth it with the hangovers i get due to being on effexor xr but its just something i want to understand how it works.
 
I am curious as well, sertraline and alcohol go together like butter and toast.
 
MXE through my research has been known to potentate the effects of alcohol enjoyably once more.
 
With sertraline, my favorite SSRI to write for younger folks if I HAVE to write one, I know its doing a lot at the serotonin receptors --> I'd blame dual SSRI and alcohol potentiation of the 5-HT3 receptor as well as depressant and metabolic alterations initiated by sertraline.

With SNRIs, you have the added effects of NE stimulation by both the alcohol and the SNRI; also, alcohol has a broad range of effects with serotonergic and dopaminergic pathways.
 
Geaux Tigers! said:
With sertraline, my favorite SSRI to write for younger folks if I HAVE to write one, I know its doing a lot at the serotonin receptors --> I'd blame dual SSRI and alcohol potentiation of the 5-HT3 receptor as well as depressant and metabolic alterations initiated by sertraline.

With SNRIs, you have the added effects of NE stimulation by both the alcohol and the SNRI; also, alcohol has a broad range of effects with serotonergic and dopaminergic pathways.
Click to expand...

Thanks doc :)
 
I was on sertraline for a while and I remember reading the alcohol potentiation was due to cytochrome p450 enzyme inhibition. I'm too lazy to look up the exact one. Its one of the ones that alcohol induces with chronic use increasing the toxicity of acetaminophen due to higher production of the bad metabolite.
 
There's a few threads on this on Wellbutrin and alcohol SNRIs and ssri's. In any case alcohol is not advised in either case. However, I have found no change at all when mixing Snri's and aalcohol. SSRI's seem to potentiate.
 
I've found this effect wears off after a few weeks on a stable dose of the SSRI (Sertraline in my case). The Alcohol potentiation becomes negligible after a short while, but it is interesting that this potentiation occurs in the first place.
 
i had 5 beers the other night, enought to catch a buzz and didnt die the next day its been a few months since ive gotten drunk so maybe those effects have worn off.
 
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