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Quetiapine / Seroquel dose advice

farmaz

farmaz

Ex-Bluelighter
Joined
May 9, 2009
Messages
2,640
Location
Shady Council estate
This is not for me it's for my deeply loved fiance. She is taking Seroquel in such huge amounts it's getting very scary for me. She has been taking up to 400/600mg per day & a few days has even topped over 1000mg in 24 hours.

I had a look on the internet too try & find the fatel dose but it was all in the weight thing (e.g. X mg per X kg) and thats no good for me to try to talk some logic in her head.

whats the fatel dose, long term & short term effects to her health etc etc?.............


thanks
 
What's wrong with the weight thing (equation)? Do some math with her weight, and there's your estimated lethal dose for someone her size.
 
Pjkt2501 said:
What's wrong with the weight thing (equation)? Do some math with her weight, and there's your estimated lethal dose for someone her size.
Click to expand...

you try getting a girl thats "big" to weigh herself or ask her about anything related to weight. I said 1 thing related to jabba the hut from starwars a few weeks ago when drunk & got hit.

It sounds such a simple task but she has a serious issue with what she weighs, It's not such a simple task as you make it sound
 
farmaz said:
This is not for me it's for my deeply loved fiance. She is taking Seroquel in such huge amounts it's getting very scary for me. She has been taking up to 400/600mg per day & a few days has even topped over 1000mg in 24 hours.

I had a look on the internet too try & find the fatel dose but it was all in the weight thing (e.g. X mg per X kg) and thats no good for me to try to talk some logic in her head.

whats the fatel dose, long term & short term effects to her health etc etc?.............


thanks
Click to expand...

What dose is your fiance prescribed?

The recommended dose range for adults is 400 mg to 750/800 mg, according to the Seroquel prescribing information:

http://www1.astrazeneca-us.com/pi/Seroquel.pdf
 
I have taken seroquel for 8 + years (top end of reccomended dosing spectrum), and I follow news about it and I have never heard of a fatal overdose from seroquel alone.

Seroquel is not very likely to kill your girlfriend IMO. I'm not saying it is good to abuse, but as long as she is not mixing it with other drugs I am extremely confident that she is not likely to die from the dosages you mentioned. I have read about people taking much higher doses and they reported some ill feelings and sleeping for a long time.

Is she actually prescribed the seroquel or using it recreationally?

I ask because one of the side effects of seroquel is weight gain because it tricks your brain into thinking you are hungry even if your stomach is completely stuffed. If she is not prescribed seroquel then it is possible she does not know about this side effect.

Edit*

In response to your question about other side effects: Weight gain, diabetes, high cholesterol, tardive dyskinesia (uncontrollable twitches in the face, loss of tongue control) the list goes on and on. I wish I did not have to take this drug but the bottom line is that my life would probably be a disaster without it. This drug should not really be taken for a prolonged period of time without the supervision of a doctor because they will monitor cholesterol and blood sugar levels.

Edit*

http://ajp.psychiatryonline.org/article.aspx?articleID=175921 Here is a link to a peer reviewed (scientific) article concerning seroquel overdose.
 
Last edited:
ihatepipes said:
I have taken seroquel for 8 + years (top end of reccomended dosing spectrum), and I follow news about it and I have never heard of a fatal overdose from seroquel alone.

Seroquel is not very likely to kill your girlfriend IMO. I'm not saying it is good to abuse, but as long as she is not mixing it with other drugs I am extremely confident that she is not likely to die from the dosages you mentioned. I have read about people taking much higher doses and they reported some ill feelings and sleeping for a long time.

Is she actually prescribed the seroquel or using it recreationally?

I ask because one of the side effects of seroquel is weight gain because it tricks your brain into thinking you are hungry even if your stomach is completely stuffed. If she is not prescribed seroquel then it is possible she does not know about this side effect.

Edit*

In response to your question about other side effects: Weight gain, diabetes, high cholesterol, tardive dyskinesia (uncontrollable twitches in the face, loss of tongue control) the list goes on and on. I wish I did not have to take this drug but the bottom line is that my life would probably be a disaster without it. This drug should not really be taken for a prolonged period of time without the supervision of a doctor because they will monitor cholesterol and blood sugar levels.

Edit*

http://ajp.psychiatryonline.org/article.aspx?articleID=175921 Here is a link to a peer reviewed (scientific) article concerning seroquel overdose.
Click to expand...

What dose are you on?

I'm on 25 mg to 100 mg for sleep as needed. Been taking it for a couple of years.

What side effects have you experienced? Do you have tardive dyskinesia?

I'm not overweight, don't have diabetes, BSL is fine, cholesterol is fine and don't have tardive dyskinesia.
 
I have taken upwards of 600 - 1000 mgs 8 + years. Most side effects are not very pronounced at your dosage from what I have read.

Extreme weight gain is the thing I have had the most problems with, and this is where the problems of high blood sugar and cholesterol come into play. I always crave sweet and salty snacks too. It is so hard to force myself not to eat after I take my dose.
 
^ If she's prescribed it then she should definitely speak to her doctor - there is a cardiovascular risk associated with quetiapine, and being overweight also increases the risk.

800mg/day is usually the max prescribed dose. I don't know what the LD50 is, but I would be more concerned about the more long term side effects mentioned by other posters unless she is continually increasing her dose?
 
Effie, you took the words right off the tip of my tongue. This is the point I was trying to make so thank you.
 
ihatepipes said:
I have taken seroquel for 8 + years (top end of reccomended dosing spectrum), and I follow news about it and I have never heard of a fatal overdose from seroquel alone.

Seroquel is not very likely to kill your girlfriend IMO. I'm not saying it is good to abuse, but as long as she is not mixing it with other drugs I am extremely confident that she is not likely to die from the dosages you mentioned. I have read about people taking much higher doses and they reported some ill feelings and sleeping for a long time.

Is she actually prescribed the seroquel or using it recreationally?

I ask because one of the side effects of seroquel is weight gain because it tricks your brain into thinking you are hungry even if your stomach is completely stuffed. If she is not prescribed seroquel then it is possible she does not know about this side effect.

Edit*

In response to your question about other side effects: Weight gain, diabetes, high cholesterol, tardive dyskinesia (uncontrollable twitches in the face, loss of tongue control) the list goes on and on. I wish I did not have to take this drug but the bottom line is that my life would probably be a disaster without it. This drug should not really be taken for a prolonged period of time without the supervision of a doctor because they will monitor cholesterol and blood sugar levels.

Edit*

http://ajp.psychiatryonline.org/article.aspx?articleID=175921 Here is a link to a peer reviewed (scientific) article concerning seroquel overdose.
Click to expand...

thank you
 
ihatepipes said:
I have taken upwards of 600 - 1000 mgs 8 + years. Most side effects are not very pronounced at your dosage from what I have read.

Extreme weight gain is the thing I have had the most problems with, and this is where the problems of high blood sugar and cholesterol come into play. I always crave sweet and salty snacks too. It is so hard to force myself not to eat after I take my dose.
Click to expand...

What about tardive dyskinesia?
 
There is less of a risk of tardive dyskinesia than with the older "typical" antipsychotics, but there is still a risk, yes. However the cardiovascular risk is more prominent with quetiapine..
 
kaiba said:
What about tardive dyskinesia?
Click to expand...

No signs of tardive dyskinesia as of yet, but the risk is serious enough that my psychiatrist has me perform a special test where I do different things with my hands, while looking at him, while he watches for any unusual facial movements ( he even has me do one while I stick my tongue out).

Effie is right on the money again in terms of the fact that tardive dyskinesia is less common with newer antipsychotics. However quetiapine is still a relatively new drug (ie. there is no generic formulation) so no one can actually speak of the long term effects without any certainty as far as I know.
 
Last edited:
ihatepipes said:
No signs of tardive dyskinesia as of yet, but the risk is serious enough that my psychiatrist has me perform a special test where I do different things with my hands, while looking at him, while he watches for any unusual facial movements ( he even has me do one while I stick my tongue out).

Effie is right on the money again in terms of the fact that tardive dyskinesia is less common with newer antipsychotics. However quetiapine is still a relatively new drug (ie. there is no generic formulation) so no one can actually speak of the long term effects without any certainty as far as I know.
Click to expand...

I've read somewhere that seroquel at low doses (25 mg to 100 mg) doesn't cause tardive dyskinesia because at low doses it doesn't target dopamine receptors (which causes tardive dyskinesia).

If I remember correctly, I read in another forum, a guy taking 100 mg at night for 8 years (for sleep) without any side effects.

Actually, seroquel at low doses is a different drug (it's not an antipsychotic - it's an antihistamine).

Check out this article:

http://thelastpsychiatrist.com/2007/07/the_most_important_article_on.html

Have you read this Seroquel article?
 
Yep very true, I've not read that article but you are spot on about the histamine/dopamine receptors. I will read now, thanks! (Well, later this eve :) )
 
I was scripted 1000mg quetiapine (400xr morning and 600ir at night) for well over a year.

It's not going to kill her but there are a fuckton of side effects. For one i've been off it and all other AAP's for well over 8 months now and I still show signs of Tardive Dyskinesia which could be permanent.
 
kaiba said:
I've read somewhere that seroquel at low doses (25 mg to 100 mg) doesn't cause tardive dyskinesia because at low doses it doesn't target dopamine receptors (which causes tardive dyskinesia).

If I remember correctly, I read in another forum, a guy taking 100 mg at night for 8 years (for sleep) without any side effects.

Actually, seroquel at low doses is a different drug (it's not an antipsychotic - it's an antihistamine).

Check out this article:

http://thelastpsychiatrist.com/2007/07/the_most_important_article_on.html

Have you read this Seroquel article?
Click to expand...

Tell me if i'm wrong but I feel like you have something to say that you are not saying...
 
Tripman said:
I was scripted 1000mg quetiapine (400xr morning and 600ir at night) for well over a year.

It's not going to kill her but there are a fuckton of side effects. For one i've been off it and all other AAP's for well over 8 months now and I still show signs of Tardive Dyskinesia which could be permanent.
Click to expand...

Tripman, I am so sorry to hear that. It is something I think about every time I take my meds. What are they doing to treat whatever conditions you were being treated for? How is your life off the meds?
 
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