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MDAI - Lasting depression/hangover

Intrinsic man

Intrinsic man

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Sep 22, 2011
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Saturday night at around 12:20 PM myself and my girlfiend ingested about 210-220 mg. of MDAI. What followed was one of the worst nights ever. I felt very weird and my brain felt like it was being scratched. The anxiety was terrible. I got weird feelings in my body and the back of my neck was experiencing odd sensations of warmth/an icy feeling. I was also feeling moderately nauseaus through out the night. The most predominant feeling of all was the sensation of being either freezing or way too hot. After about 3 hours we acquired some hydroxyzine (pretty much a benzo) in the hopes that it would make us feel better and maybe allow us to sleep. I'm pretty sure I got at least 4 hours of seep, maybe more, but I remained awake for the first 4 or 5 hours trying to sleep.

The next day I woke up feeling more depressed than I ever had in my entire life. My head still had the weird spacey pressure feeling like the night before only less intense. I was still experiencing the hot/cold flashes only less severe as the night before. The world was a colorless place and I couldnt do anything without feeling awkward and distant (best way to describe it). I couldn't really eat anything the whole day even though I was very hungry. As time went on I started feeling better, but I never felt back to normal.

Now it is Monday, the second day after taking the MDAI and I seem to be feeling a bit better but not completely back to normal. My head still has pressure around it and I still feel a bit off. I don't know what this drug did to me but I am hoping I didnt do any real damage and that this is just a serious hangover/comedown I am experiencing. I don't see how it could possibly last forever. I was hoping someone with experience or knowledge could give me some good news or at least some information I could use. Do you think taking a 5-htp would help? I was worried that it may make me feel even more wierd but now I'm wondering if that's exactly what I need.

Thanks in advance!
 
Yup, give 5-HTP a try, the feeling should go away in a few days, obviously MDAI doesn't agree with you
 
You should just take it easy until you feel better, take multivitamins, get normal excercise, and avoid any drugs until you're feeling normal. I've never been a fan of 5htp because there have been reports of it having adverse reactions with seratogenic drugs, and would be especially careful with a seratogenic drug that we know nothing about.
 
Amu said:
Yup, give 5-HTP a try, the feeling should go away in a few days, obviously MDAI doesn't agree with you
Click to expand...

OR, its not MDAI at all. Which is what this sounds like to me.

We dont do substance ID here though, so we cant help you there.


5-HTP is helpful, but L-Tryptophan is the same exact thing, but without all the risks, and is much much more effective.



It sounds like some shitty RC dealer gave you some piperazines instead man, you cant trust these chemical companies, some are worse than the dealers around here.


Take a nice long break, smoke minimal weed, dont drink at all, stay away from ANY psychedelics or empathogens, and youll be back to normal in a day or two
 
Thanks for the replies.

I believe what I got was infact MDAI, however nobody can kow for sure. My friend has taken the same stuff I took at a much higher dose mixed with Ethalone and he loved it. One of the biggest reasons why I think it is MDAI is because my symptoms match that of too much seratonin. The hot/cold feeling, the depression the next day etc.

What are piperazines? Are they dangerous? I will certianly look into the L-Tryptophan today. Can you elaborate on your reluctancy towards 5-htp... do you think adding more seratonin to the equation could be bad? It has been two days since I took the MDAI so it shouldnt be active anymore, furthermore I think what I am experiencing may be a lack of seratonin but I cannot know for sure.
 
Well 5-HTP is converted to L-Tryptophan, which is converted into serotonin (basically atleast). Taking the prodrug (5-HTP in this case) of another drug is always really ineffective.

Also I believe they found some slight toxic effects from the 5-HTP that isnt converted, so its just better lol...



What your experiencing is not TOO MUCH serotonin, but most likely too little. Just get some rest, youll be back to normal in no time!
 
Folley said:
Well 5-HTP is converted to L-Tryptophan, which is converted into serotonin (basically atleast). Taking the prodrug (5-HTP in this case) of another drug is always really ineffective.

Also I believe they found some slight toxic effects from the 5-HTP that isnt converted, so its just better lol...



What your experiencing is not TOO MUCH serotonin, but most likely too little. Just get some rest, youll be back to normal in no time!
Click to expand...

No, 5-HTP is converted into serotonin directly, while L-Tryptophan is first converted into 5-HTP. 5-HTP is indeed superior to L-Tryptophan and is the rate-limiting step.

http://upload.wikimedia.org/wikipedia/commons/0/0b/Tryptophan_metabolism.png
 
Amu said:
No, 5-HTP is converted into serotonin directly, while L-Tryptophan is first converted into 5-HTP. 5-HTP is indeed superior to L-Tryptophan and is the rate-limiting step.

http://upload.wikimedia.org/wikipedia/commons/0/0b/Tryptophan_metabolism.png
Click to expand...

This had always been my understanding, however, I have read that it is better to take L-Tryptophan daily being as it is an important part of our chemistry and 5-htp is not... also, many adults suffer from depression due to an L-Tryptophan deficiency.
 
True but in the context of MDMA, 5-HTP is better since the enzyme that makes it is compromised by MDMA. Also, can you post the link to the study? I'm curious about how it works.
 
It was cold winter evening (21th of January). We (young couple) decided to try out MDAI cause we had heard so much good about it. With good expectations we took about 180mg and it turned out to be a nightmare.
Main effects within 6 hours included anxiety attacks, more effective than in other drugs. All we could do was to lay in the bed and hold each other, we thought we would die. No euphoria.. Head felt buzzy.. At some point we managed to fall asleep. We slept the whole next 24 hours atleast. After we woke up we ate and other one of us got panic attacks again and other one called emergency line. Fortunately we managed to sleep again.. The next morning was almost like the previous.. In total at least three days of anxiety attacks and depression and hangover which like we had never experienced from any substances( and we've had bad hangovers from different subs / stimulants before this).
Maybe it was the patch or simply the substance didn't work for us honestly. We threw the rest of the substance into the trash bin.
Phef, we're happy to be alive!
 
serotonin

Heheh

You have mowed down some of your serotonin dendrites. They will grow back stronger in time.

Stay away from 5-htp when using serotonin drugs.... It will blow your head off literally .
Don't use it to recover you need a rest from serotonin not another blow to the head.

You will be ok... Doesn't sound like you have tinnitus or cochlear loss.

The tight head feeling can last upto 12months, by the sound of it you only had a minor incident.

I took 10g MDAI with 3or4 5-htp capsules

It's been 18 months now and still not fully recovered.

The tight feeling has gone recently...
That goes when the serotonin around the outside of your brain comes back on.

I blew the whole lot. Still waiting for more to reactivate.

Read this :
And also look at tassili cave art.


Mechanisms of regrowth of the bulbospinal serotonin system following 5,6-dihydroxytryptamine induced axotomy. I. Biochemical correlates

Anders Björklund, Leif Wiklund

Department of Histology, University of Lund, Lund Sweden

Accepted 8 November 1979. Available online 12 March 2003.

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Abstract

The regrowth of the bulbospinal serotonin neurons after 5,6-dihydroxytryptamine (5,6-DHT)-induced axotomy has been followed between 1–2 weeks and 8 months after neurotoxin injection, using determinations of endogenous serotonin (5-HT) and [ 3 H]5-HT uptake, and measurements of the conversion of [ 3 H]tryptophan ([ 3 H]TP)into [ 3 H]5-HT and [ 3 H]5-HIAA in vitro.In the spinal cord there was, at 2weeks after the 5,6-DHT treatment (75μg), adrastic reduction in all three parameters throughout the cord signifying that the 5,6-DHT-induced axotomy causes an almost complete denervation of the spinal cord from the lumbar up to the most cranial cervical segments. With time there was a gradual recovery in the[ 3 H] 5-HT uptake, which appeared to progress in acranio-caudal direction. By 2 months the recovery was noted mainly in the (*1) upper cervical segments; by 4 months it was evident also in (*2) the lower cervical segments, and by 8 months it had reached the (3*) thoracic and lumbar segments. By 7–8 months, when the [ 3 H] 5-HT uptake had recovered to 60% of normal in the upper cervical segments and to 25% of normal in the lumbar cord, endogenous 5-HT had recovered to 34% of the age-matched vehicle-treated controls in the cervical cord and to 13% in the lumbar cord, while the [ 3 H] 5-HT synthesis from [ 3 H] TP had recovered to about 40–50%. The [ 3 H]5-HIAA/[ 3 H]5-HT ratio (reflecting the rate of metabolism of the newly synthesized transmitter) and the medium/tissue ratio (reflecting the rate of spontaneous release under the in vitro conditions) had undergone a more than two-fold increase in the long-term 5,6-DHT-treated rats, indicating an increased turnover of the transmitter in the partially reinnervated spinal cord.

In medulla oblongata, where the cell bodies of origin of the bulbospinal serotonin neurons, as well as proximal terminal areas are located, there was acutely a partial (40–50%) reduction in [ 3 H]5-HT uptake and [ 3 H]5-HT synthesis capacity, where as the endogenous 5-HT content was increased by 30% (due to accumulation of the transmitter in the lesioned axon stumps).*There was a rapid and extensive recovery, resulting in supranormal values in all three parameters by 7–8 months*. This was accompanied by a marked retardation of the in vitro turnover of newly-synthesized [ 3 H]5-HT (reflected in marked reductions in the[ 3 H]5-HIAA/[ 3 H]5-HT and the medium/tissue ratios).

The results demonstrate an extensive recovery of the neurotransmitter biosynthetic machinery during regeneration of the chemically axotomized serotonin neurons. Moreover,the observations of increased transmitter turnover in the re innervated areas in the spinal cord and decreased turnover in the hyper innervated brain stem areas suggest that regional compensatory mechanisms may alleviate the functional consequences of the regenerated terminals. It is proposed that with a combination of axonal regeneration, increased utilization of the transmitter, and development of receptor super sensitivity also an complete regeneration, resulting in complete re innervation of an area, can become efficient in restoring complete

function in the CNS...

You must realize this is over 8months,and for rats.... In humans recovery takes a lot longer.... And yes is a different chemical but similar dynamics. You overloaded serotonin.

Mdai works in specific areas and very concentrated unlike mdma which works all over wider area.


Godspeed on your recovery
 
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could it works for MDMA neurotoxicity? some study related?

When u sayd mdma works all over wider...means its better or even worst?...nice to read some science :) !
 
derok said:
could it works for MDMA neurotoxicity? some study related?

When u sayd mdma works all over wider...means its better or even worst?...nice to read some science :) !
Click to expand...

Better dont do drugs
 
too late man!! xD im already fuked ! 10th dose...1 year in the hell...goint out little by little..as you see its my concern every mdma related research and recover.
 
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