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Opioids Feeling Things That Aren't There on Methadone

psilocybinsane said:
I used to get the same side effects from methadone when i had little opiate tolerance. its strong stuff man
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what doses were you taking, and what were the normal doses of other opiates for you? and if you dont mind me asking, how much do you weigh?
 
you guys have got to be right - as much as I don't want to believe its true... I've seen the guy open the bottles in front of me before, but he's told me that a lot of people stick a syringe underneath the foil to add water -- and some people at the clinics immediately head straight to the bathroom after getting their 'done to water it down (from what I've heard)..
Just can't trust drug dealers... no matter how close they are to you.
A 30mg IR oxycodone should never be more powerful than 30mg of methadone, right? No matter what variables there are with enzymes or whatever else, 30mg of methadone should be waaaay beyond a milligram:milligram equivalency with any of the codones, right?
One time when I took 30mg of methadone in pill form, it was the most powerful opiate I had ever done in my life, and I was so sedated I feared for my life for a few hours... and my hydrocodone tolerance was the same back then as it was now (20-45mg of hydro needed for a high)...

The 'guy' in question has offered a few explanations for the methadone not being as potent as pill form; one of his explanations is that liquid methadone begins absorbing immediately but also absorbs over a longer period of time - therefore it just doesn't have the same kick behind it as pill form, watered down or not.
 
30 mg methadone should be (is always) more potent than 30 mg oxycodone (IR or ER). Methadone is indeed stronger than hydrocodone (by FAR) and oxycodone (by ALMOST as far ;)). 30 mg methadone (in pill form) should be exactly as 30 mg in liquid form -- UNLESS clearly, you are getting a watered down or diluted version of liquid methadone (as it seems is suspected in this case). Great decision on 'not buying from that dude anymore' . It's true - can't really trust anyone.
 
As i was reading the post this is exactly what i was thinking about.. watch out for those ghosts.

Heres a little story about ghosts.
A friend of mine lived by himself at this old house near a cemetary. He was always hearing loud bangs cold feelings and he would say he would be sleeping in his bed and it felt like someone would get in the bed beside him. the bed would move and everything and this awful smell would start to come. stuff like that in this certain part of his house. He smoked rock so people said that he was just partying to much and that he needed sleep. When really he was smoking more rock just to stay up cause he didnt understand what was going on. Well he use to have this room in the back of the house (where all this shit happened) that the window would always open, so the one day i was there he decided to nail these 6 inch spikes into the window so that it could not open. Well we were getting high and all of a sudden heard this loud bang. so we went to check it out and this frigging window was wide open with all the spikes sticking out. After I seen think that i didnt think that he was just losing it from the rock and no sleep. So just watch out your house might just be haunted..
 
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whatsup73 said:
As i was reading the post this is exactly what i was thinking about.. watch out for those ghosts.

Heres a little story about ghosts.
A friend of mine lived by himself at this old house near a cemetary. He was always hearing loud bangs cold feelings and he would say he would be sleeping in his bed and it felt like someone would get in the bed beside him. the bed would move and everything and this awful smell would start to come. stuff like that in this certain part of his house. He smoked rock so people said that he was just partying to much and that he needed sleep. When really he was smoking more rock just to stay up cause he didnt understand what was going on. Well he use to have this room in the back of the house (where all this shit happened) that the window would always open, so the one day i was there he decided to nail these 6 inch spikes into the window so that it could not open. Well we were getting high and all of a sudden heard this loud bang. so we went to check it out and this frigging window was wide open with all the spikes sticking out. After I seen think that i didnt think that he was just losing it from the rock and no sleep. So just watch out your house might just be haunted..
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Fucking hell man...
 
whatsup73 said:
As i was reading the post this is exactly what i was thinking about.. watch out for those ghosts.

Heres a little story about ghosts.
A friend of mine lived by himself at this old house near a cemetary. He was always hearing loud bangs cold feelings and he would say he would be sleeping in his bed and it felt like someone would get in the bed beside him. the bed would move and everything and this awful smell would start to come. stuff like that in this certain part of his house. He smoked rock so people said that he was just partying to much and that he needed sleep. When really he was smoking more rock just to stay up cause he didnt understand what was going on. Well he use to have this room in the back of the house (where all this shit happened) that the window would always open, so the one day i was there he decided to nail these 6 inch spikes into the window so that it could not open. Well we were getting high and all of a sudden heard this loud bang. so we went to check it out and this frigging window was wide open with all the spikes sticking out. After I seen think that i didnt think that he was just losing it from the rock and no sleep. So just watch out your house might just be haunted..
Click to expand...
I don't think this house is haunted at all; if any spirits are here, they must be good ones. My roommate who owns the house also grew up in this house. Both his mother and brother died when he was a teenager -- if any ghosts are here, it might be theirs, and therefore I think they'd be watching over us and protecting us as opposed to performing mischief...
If you're superstitious, that is
 
Is there anybody willing to comment on cigarette's effect of inducing CYP450 enzymes, and how this might affect methadone and oxycodone?
In theory, induction of CYP450 would cause more oxycodone to be metabolized into oxymorphone, but it would have a negative effect on methadone metabolism and cause it to metabolize quicker --
if the induction of CYP450 is significant, would the ratio of equivalency for methadone and oxycodone be closer to 1:1?
 
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