Opioids Lack of metabolic enzyme?

[nAON]

Basically, i've been using opis for a long time. However, i've always had a HUGE natural tolerance, even if I hadn't using be for months. Like i'd be sitting next to someone who vapes up 2mg fent and nods out, while I can sit there vaping triple that without a nod. Applies to most other drugs too, oxy, gear, etc.

I've also noticed that I tend to get the itch for much longer, today from DHC which I dosed over 24 hours ago, and often with poppy pods i'd itch for 3 days. So my theory is that if im lacking the enzyme needed to metabolise them, and the opis are prodrugs, then its gonna be a much more extended effect releasing [histamines] over a long time.

Now i've read before that many people lack or have lesser function versions of various CYP enzymes, there were some values on how it varies with ethnicity but I can't seem to find it now. Does this seem to be an indication that I lack this enzyme, or it acts weakly?
And if so, what can I do about it, I know stuff like white grapefruit juice can inhibit metabolism. But is there anything that can make it work stronger?

 

[laCster]

if you had deficient enzymes, then you would receive 10x the normal effect of oxycodone. pro-drugs would absolutely blow for you, but oxycodone, methadone, morphine/heroin (debated do to 6-MAM), ect... would give you astronomical effects that would last 6+ hours because of the inability to metabolize the substance.

 

[percozakk]

I have a similar problem, though all my opiates seem to last much shorter. I too have a high natural tolerance. From the time i started i was taking 30+ mg of hydrocodone as well as oxycodone.
But my high never lasts longer thn 2 hours. I will peak at about the one hour mark, and by the 2 hour mark i am almost at baseline. Could this be from overactive enzymes or metabolism?

 

[paper planes]

thats crazy i wish i could be faded for hours on hours...but when you refer to other drugs are you saying they might not feel cocaine and stuff like that

 

[nAON]

Referring to opis only. And it's only the itching effect that lasts particular long, but this I suspect only occurs in pro-drugs to histamine-releasing active opis. The actual effect I feel is relatively little, ie. when I first took oxy (with no tolerance) i didnt even feel anything below 60mg. Similarly, i can smoke fent with someone, I can smoke it literally non stop without nodding, while most people I see nod out after 1-2mg smoked.

 

[ErgicMergic]

if you had deficient enzymes, then you would receive 10x the normal effect of oxycodone. pro-drugs would absolutely blow for you, but oxycodone, methadone, morphine/heroin (debated do to 6-MAM), ect... would give you astronomical effects that would last 6+ hours because of the inability to metabolize the substance.

Are you 1000% sure on that? If you are, then thank you!! I was wondering why hydrocodone didn't do much for me, and why it lasted less long as my friends, and why tramadol kicked so much butt in comparison. Ultra-rapid CYP2D6 methinks