2CE/Tramadol produce a similar odd feeling

[Issac Sinclair]

Hey I don't know how to explain this but if you've taken both the substances before then you may be able to relate this feeling.

It feels like a 'body scan' where you have one thing go from one side to another. For me it is from left to right.

On 2CE, the auditory hallucinations are apparent. I feel like it is coming out of one side and out the other. Its like a warping and twisting of the sounds, where I can feel it in my head at the left and out the right.

On Tramadol, it is a feeling of warmth and the 'scan feeling'. It goes from one side to another but I feel it more on my back.

I don't know how else to explain how I feel. I think I might be missing a medical term that someone can point me to, or something obvious. If not, anyone else felt this before?

 

[FattyAcid]

nope

 

[Albion]

I'm betting folk in PD have a lot to say about this. I'll move this over there if you can't get any better answers than 'nope'.

 

[ErgicMergic]

Maybe the warm feeling from the tram is the serotonin moving through your body and brain? My brother said, when mixing 1 hit LSD and 100mg tram (not recommended), that he got these incredibly warm, euphoric rushes coursing through his body, especially when he did some light weightlifting on the LSD comeup. It would especially be in his chest, and he could feel the warm wave when he put his palm on his chest.

 

[Albion]

Maybe the warm feeling from the tram is the serotonin moving through your body and brain? My brother said, when mixing 1 hit LSD and 100mg tram (not recommended), that he got these incredibly warm, euphoric rushes coursing through his body, especially when he did some light weightlifting on the LSD comeup. It would especially be in his chest, and he could feel the warm wave when he put his palm on his chest.

Mixing LSD and tramadol sounds like a good way of winding up with genuine serotonin syndrome....Gonna move this to PD, though I'm not entirely sure who's best to answer this.

 

[ErgicMergic]

Mixing LSD and tramadol sounds like a good way of winding up with genuine serotonin syndrome....Gonna move this to PD, though I'm not entirely sure who's best to answer this.

Of course, that's why I didn't recommended it. Shambles had SS from only 100mg tram and 1.5 hit of LSD, so this had me worried during the trip, but all was well. It was just a slightly more stimulated trip, and people in PD reassured me after the fact that the doses were on the low side; people had mixed MDMA at high doses and LSD, much more SS risk there. I was just making a point about serotonin from a psychedelic and tramadol, much like 2CE and Tramadol.

 

[Issac Sinclair]

It feels like a stuttering glow or a warm shuddering, where it moves from one side of my head/body to another. Its completely pleasant and happens only when I lay down. Thanks for moving this, I have no idea what to call it or even if anyone else experiences it.

 

[Ismene]

Of course, that's why I didn't recommended it. Shambles had SS from only 100mg tram and 1.5 hit of LSD, so this had me worried during the trip

I'm not convinced that's evidence that tramadol causes "serotonin syndrome". Particularly not 100mg and 1.5 hits of LSD - especially seeing as LSD doesn't "release serotonin" anyway. That sounds like a unique reaction by one person to a drug. It's like saying "one guy in the paper the other day took two MDMA pills and dropped dead". That's fine and kinda interesting but it doesn't account for the other 50 million people who took 2 pills and had a great time.

 

[Moonshake]

Well I have a question, does tramadol release serotonin or inhibit its reputake, I think I have seen conflicting things. BTW 2c-e is an serotonin reputake inhibitor, I'm not sure how potent though.

I am confused as well, how could mixing an an SRI/SRA with LSD give one serotonin syndrome anyway, I thought LSD did not directly affect serotonin concentrations[not SRI/MAOI/SRA] (or is it more complicated than that).

I have had a bout of what I believe to be SS when a long time ago I stupidly combined (after reading an erowid report) a few grams of rue with like 80-90mg 5-meo-dalt, (also 1/4 medium dried amanita cap, doubt this had much effect though) and a bag of salt and vinegar potato chips (as I remember). Was pretty horrifying, thank god it only lasted a few hours, and I was able to get out of the dark forest and into my friends house before it really started getting hairy.

In regards to the OP's query....I have no idea, I've never experienced anything quite like that, 2c-e always seemed constant and centered to me in terms of body feeling. No "rushes", even with weed.

Now I have gotten a warm prickly glow moving across my body before, but it was from, I think, a moderate amount of morphine, cannabinoids and a bit of d-amph, it happened a couple times. I don't know if its what you're talking about though.

 

[Jesusgreen]

^ Interesting, I was not aware of the 2Cs having reuptake inhibition action until now, so thanks for posting this. I've been reading a little more about it since your post, and it seems their effects are a huge magnitude less than those of things like MDMA etc, which makes sense - but the fact that they are monoamine reuptake inhibitors explains some of their unique effects.

Tramadol is also a serotonin reuptake inhibitor (as well as a releaser it seems).

 

[Moonshake]

Someone should update the wiki page for tramadol in that case, it says in the introduction that tramadol "Tramadol possesses weak agonist actions at the μ-opioid receptor, releases serotonin, and inhibits the reuptake of norepinephrine"

Also the wiki on drugs-forum has a chart that includes the activity of 2c-e and several other psychedelics at inhibiting serotonin reputake.

 

[Jesusgreen]

My mistake, it seems to both inhibit reuptake *and* release serotonin!

 

[Ismene]

I have had a bout of what I believe to be SS when a long time ago I stupidly combined (after reading an erowid report) a few grams of rue with like 80-90mg 5-meo-dalt, (also 1/4 medium dried amanita cap, doubt this had much effect though) and a bag of salt and vinegar potato chips (as I remember).

Any reason why you thought it was SS rather than complications from the MAOI or well-dodgy drugs like meo-dalt and amanita?

 

[bluedolphin]

Of course, that's why I didn't recommended it. Shambles had SS from only 100mg tram and 1.5 hit of LSD, so this had me worried during the trip, but all was well. It was just a slightly more stimulated trip, and people in PD reassured me after the fact that the doses were on the low side; people had mixed MDMA at high doses and LSD, much more SS risk there. I was just making a point about serotonin from a psychedelic and tramadol, much like 2CE and Tramadol.

Yeah 100mg of Tramadol and any amount of LSD will be fine. Just like a reasonable (or even excessive) amount of MDMA and any amount of LSD will be fine.

The prior has not been widely tested and affirmed but it's obviously the case. The latter has been pushed to the limits by every kid who goes to his first festival and they all live to tell the tale

 

[Ismene]

LSD and MDMA is the brandy of psychedelics. I've taken it dozens of times. And I can't seen 100mg of tramadol releasing as much serotonin as MDMA!

 

[Moonshake]

Any reason why you thought it was SS rather than complications from the MAOI or well-dodgy drugs like meo-dalt and amanita?

Well I thought it might have been SS from combining 5-meo-dalt with the MAOI. And yes I think also the possible food complications with the MAOI also definitely played a role. in regards to the amanita, as I remember it I consumed hardly any in fear that it would interact with the maoi, certainly not enough to produce signifigant effects of its own (though it may have been enough to fuck w the maoi). My experience was totally different from the Erowid report of combining 5-meo-dalt and syrian rue at similar dosages, so I suspect something went wrong beyond an interaction between 5-meo-dalt and the rue. I also MAY have had some benadryl beforehand to help with possible nausea, I am not sure if that was a smart decision either.

I had used 5-meo-dalt at highish doses orally alone (80mg) and felt VERY little, and smoked I had gotten a rush and the fishbowl effects (along with a racing heart). My experience that night felt totally different with my experiences with 5-meo-dalt alone and with cannabinoids (though there were some similarities).

 

[Issac Sinclair]

I forgot I made this topic. So its safe to assume that the effects I was experiencing were due to serotonin effects?

Is there a proper medical term for it?