i think it affects people differently Dan, i can do meph 3, even 4 times a week, usually 500mg or less in a sesh, but once a week possibly 750mg-a g ish, i have almost negligible comedowns from it....
IF I do it 3 days in a row I'l get some numbness etc, and feel a bit tired, so give it a break, but it VERY rare I do that.
My wife drinks more than me when we do meph together, i alternate booze and pints of ribena, she gets a bad "comedown" when she's drunk a lot with the meph, however, when she delibeartely drinks less, she gets much less hangover....I really think the booze affects the comedown more than the meph, and undoubtedly they both together make it worse.....
Don't get brainzaps, M1 gives me much worse comedowns/and even zaps, proper jolting electric shocks juddering through the brain as I'm droppping off, scary, and leave me fuckin exhausted the day after a big juddering zap......don't really do M1 now for that reason, even though i love it together with meph...