Benzos Any ways to potentate Xanax?

[MusicGuy]

I've got 1mg of Xanax (alprazolam) but I don't feel any noticeable effects till 2mg. I'd like to take this tonight since I probably won't be getting anymore anytime soon. Are there anyways to potentate it?

 

[cornell22]

white grapefruit works well. has to be white not red though!

 

[MusicGuy]

white grapefruit works well. has to be white not red though!

Can you back this up with any proof?

 

[brighton]

white grapefruit works well. has to be white not red though!

i thought that gfj only works for valium

 

[lorne667]

You don't need proof. Xanax is metabolized via CYP3A4. WGFJ potentiaties CYP3A4. Ergo, it will slow down the metabolism, making it last MUCH longer. WIth Xanax specifically it doesn't make it that much stronger(unless your taking a high dose) however, if you kill the enzymes prior to dosing, you may actully feel the 1mg, not to mention it lenghten the pitiful half-life of xanax(which is why I rarely take them) so that it actually lasts a few hours.

BTW, anything that inhibits CYP3A4 will also potentiate Xanax, which includes Tagament, which is the best all around inhibitor of ALL drugs(Opioids, benzos, and even amphetamines), in my opinion. And on this subject my opinion means a lot.

 

[lorne667]

Here are some links:

Here is a great article, which discusses the CYP3A4 enzyme in depth, and also specifically says that alprolazam(Xanax) is metabolized by CYP3A4.
It also lists the various inhibitors, as well as inducers. AVOID INDUCERS they slow down metabolism, making things worse!
http://www.pharmacytimes.com/publications/issue/2008/2008-09/2008-09-868

the wikipedia page, saying that xanax(alprolazam) is metabolized by CYP3A4:
http://en.wikipedia.org/wiki/Xanax

Hope this clears things up. Enjoy, and in the future, be sure to put inhibitors to full use!!!

 

[NoArtFlav]

lyrica...if you can get it..

 

[King Hop Head]

Gabapentin potentiates Benzos, but the Grapefruit juice or Tagamet is probably easier.

 

[DaDankyDank]

Have a few beers, not too much though. I suggest having 2 and waiting a bit how you feel, and then maybe 2 more max. It's really easy to keep drinking and eventually you'll end up blacking out or wake up finding you did something incredibly stupid. I lost 2 cell phones in my house from drinking on xanax and soma, and they still haven't been found till this day.

 

[mrflowers00]

opioids

 

[Tommyboy]

opioids

More like the other way around. Be very careful if you do the benzo/opiate combo, as I believe it is the #1 cause of fatal overdose.

 

[Jakeperson]

Antacids help with absorption in your stomach

 

[Ayrios]

Alcohol. Just take it very slow and be aware that the benzo might make you more heroic in dosing. Avoid doing shots for this reason. It's pretty easy to black out on this combo, even moreso if anti-depressants or mood stabilizers are part of your daily regimen. Alcohol and benzos are like a two-part explosive where the combination exponentially eclipses the sum of the parts. Made for one another if recreation and conservation are the objectives.

You may eventually find a point in your life where 1mg (or even less) of Xanax alone actually has a significant effect on you, though it may not be recreational (primarily anxiolytic). For recreational use of benzos, it's usually a part of a combo, however dangerous and disaster-prone. I'd bet a good deal no substance per its popularity lands people in jail more often than benzo (usually xanax or valium) + another depressant. At least we're not discussing potentiation of barbiturates

 

[Thorns Have Roses]

Barbiturates have been shown to enhance binding at benzodiazepine receptor sites in rat brains. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC350525/

 

[Alex000]

Have a drink or two with it. Should be feelin' something.

 

[HaZeX]

Smoke some weed. I find when I use benzos about 2 bars at a time, and smoke a bowl, it really kicks the xanax into drive. I also like to mix Oxy into the mix...