I've been mindfucked to the point of "bad trip" state three times: twice on Ps. cyanescens & Peganum harmala combination (ten thumbs up) and my first LSD experience (single bicycle blotter). Note that all of these trips have included copious cannabis consumption. Mushrooms on their own (have never actually done cubensis) never did me harm. It was the harmala in both instances that took everything into completely removed space. The LSD experience was about a year after the syrian rue fiascos. To be fair, I totally set myself up for it by drinking a beer and clearing a bong on the comeup, so when i finally peaked i was in no condition to be walking around outdoors. Thankfully we were able to spend a while laying on wet grass in a park after midnight so i had time to reassociate my physical body. We called a friend who picked us up and we went back to their apartment, so everything turned out fine.
2C-E, 2C-T-7, 2C-C, 2C-I have all been relatively calm seas compared to the above experiences. I discovered 2C-x a little while after the LSD trip, and had many low-to-medium dose trips with them. The controllability of dose might have played a role, but I also had many more 2C-X trials that did not involve cannabis. I have always been able to negotiate the trip-space far more easily while not stoned, and I think that weed probably contributed to the bad trips.
Marijuana on its own induces paranoia in a large number of people, so its addition to a trip is definitely going to amplify the "mind fuck" aspect due to its influences on emotions.
I am not saying that "mind fuck" is innately negative-- what I mean is that the cloudiness of cannabis causes difficulty navigating the inner recesses (or outer reaches). 2C-X can be delightfully evil in the right settings, and I feel that they might be easier to navigate than mushrooms, but then again I had the experience of mushrooms first before I tackled 2C-X.
Additionally, in my experience the 2C-X family is far more "bodily grounded" in its effect-- it draws closer attention to the skin compared to mushrooms, which lets you forget your own skin and immerse your head in a farther-reaching space. So I tend to use tryptamines with a more intellectual bias, compared to 2C-X with a more physical bias. YMMV.