I've never tried 5-MeO-DMT, but I've been told that the breakthrough is similar to salvia, except more psychedelic and less chaotic. I would be willing to try 5-MeO-DMT, but salvia -- I don't know. Salvia scared the shit out of me. It was instantaneous ego loss...I don't even remember putting the pipe down after smoking a hit. I was just suddenly not there, now in this weird blue-colored dimension clearly beyond our simple three dimensions of space, except I wasn't me. I was my surroundings. And I had been there for an eternity. I didn't even know who I used to be. Once my ego reappeared, I started screaming. The transition of going back to my body and mind, and rediscovering me, what it meant to be me and nothing else, frightened the hell out of me. I would say it was definitely unique and almost therapeutic in a way. I'm still not ready to discuss everything I saw in detail though. It was that crazy. Someday I might do it again, but we'll see.