A follow up study conducted in 2014 which involved Colasanti reinforced the initial findings of the 2012 publication.
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Amphetamine induced endogenous opioid release in the human brain detected with [11C]carfentanil PET: replication in an independent cohort (2014).
In summary, we have replicated our previous findings that endogenous opioid release following an amphetamine challenge can be detected in multiple regions in the living human brain using [11C]carfentanil PET imaging. Importantly, we did not find that an oral amphetamine challenge produces euphoria/‘high’, which reduces the possibility of inducing unwanted behavioural adverse effects in vulnerable patient groups. This supports the use of our PET protocol in further defining the opioid system in neuropsychiatric disorders.
Link to the full text:
Amphetamine induced endogenous opioid release in the human brain detected with [11C]carfentanil PET: replication in an independent cohort (2014).