Besides the probably harmless but silly idea of eating paper, can someone please explain if there is a specific formulation of a specific substance that benefits from this rather than chewing?
I am thinking about the usual opiates like hydrocodone, oxycodone, percocet, vicodin (yes, I know that several of those are the exact same thing) which have a bioavailability best achieved orally over any other method.
Even without APAP, you may get more of a rush or quicker acting experience from snorting, but someone please just confirm for me that making the most out of these medications is simply swallowing them, and that chewing them up to a fine paste with zero crumbles left before swallowing it is the way to get the most out of it.
Do people do this because they can't tolerate the 30 seconds to 1 minute bitterness of chewing up some pills?
Again, I realize that snorting may be faster onset- but you lose 50% of the bioavailability, and that plugging may avoid some metabolism but is still WAY LESS bioavailable...
So am I correct in that the highest bioavailability for these specific substances would just be chewing them up and swallowing them?
If not, why?
Even if plugging them is the same bioavailability, the amount you would lose by the time you crushed everything up and put it in some kind of enema type thing seems like it would be a total waste of time. And there is no way that just coating a tablet with some lube and sticking it up your butt would be an efficient way of making the most.
I am mainly asking because I need to make the most of my medications and there are thousands of threads suggesting that there is a better way than just chewing 'em up and swallowing them. I am not squeamish about any of this but need some answers.
