FunctionalOlfactio
Bluelighter
- Joined
- Jun 19, 2013
- Messages
- 239
We'll want to get started researching this^ on http://www.pubmed.gov.
That's an urban legend.Chronic LSD alters gene expression profiles in the mPFC relevant to schizophrenia.
I've been through eras of weekly psychedelic use. I generally find that after 7 days my tolerance is around 90% back to normal. I never experienced any adverse effects. In fact, I would probably be using weekly right now if the time constraints of having a job and a relationship didn't make that inconvenient.
Chronic LSD alters gene expression profiles in the mPFC relevant to schizophrenia.
This was only found in the orange juice study where inmates were tested for liability to spill.
Yes.
http://en.wikipedia.org/wiki/Operation_Midnight_ClimaxWikipedia said:Operation Midnight Climax was an operation initially established by Sidney Gottlieb and placed under the direction of Narcotics Bureau officer George Hunter White under the alias of Morgan Hall for the CIA as a sub-project of Project MKULTRA, the CIA mind-control research program that began in the 1950s.[1]
The project consisted of a web of CIA-run safehouses in San Francisco, Marin, and New York. It was established in order to study the effects of LSD on unconsenting individuals. Prostitutes on the CIA payroll were instructed to lure clients back to the safehouses, where they were surreptitiously plied with a wide range of substances, including LSD, and monitored behind one-way glass. Several significant operational techniques were developed in this theater, including extensive research into sexual blackmail, surveillance technology, and the possible use of mind-altering drugs in field operations.
Chronic LSD alters gene expression
Danuta Marona-Lewicka said:3.6. Multiple neurotransmitter system-related genes in medial prefrontal cortex are altered by chronic LSD treatment
One month after cessation of chronic LSD, mRNA for both the D2 dopamine receptor (DRD2) and neuron-derived orphan receptor 1 (NOR1) is significantly elevated in prefrontal cortex, whereas the mRNA for the serotonin 5-HT2C receptor (HTR2C) is significantly lowered in comparison to saline treated rats (fig. 8). The direction of change for each of these genes (with the exception of NOR1, for which there are no published data), is consistent with reports in the literature of mRNA expression for these genes in postmortem schizophrenic brain cortex. These results demonstrate that the serotonin and dopamine systems in mPFC are each affected by chronic LSD when examined some time after discontinuation of LSD treatment. More extensive analyses of gene expression changes are currently underway.
Danuta Marona-Lewicka said:The spontaneous hyperactivity that lasts for at least many months after chronic LSD is unusual, and we have never observed this phenomenon after prolonged administration of any other psychoactive drug employed in our lab. Several drugs (e.g. psychostimulants) produce behavioral sensitization, but a challenge drug is necessary to elicit hyperactivity or the elevated response. Further, sensitized responses are generally reversible by antagonists that inhibit the acute effects of the compound that produced the sensitization. By contrast, our data show that MDL 100907, which is able to block the acute effects of LSD, is inert in inhibiting spontaneous hyperactivity after chronic LSD exposure, suggesting that the mechanism responsible for this effect is different than that of acute LSD.
This is true.
That's definitely one way to pass the blood brain barrierNot in humans it isn't. Chronic LSD exposure in rats will be similar to what they do with MDMA in rats - inject enormous quantities directly into their brains every 4 hours for days on end. No human can ever attain such concentrations in their brain unless they had someone injecting it directly through their skull.
Not in humans it isn't.
Did you know going to the library 'rewires your brain'?
Even if you just sit in the back ogling the librarian?