Since LSD is not metabolized by MAO, we would expect either no interaction or reduced effects. Why reduced fx? Chronic administration of an MAOAI could lead to down-regulation of serotonergic receptors key to LSD's fx.
ebola
chronic administration in a pharmaceutical context yes, but i can imagine a one-time dose of harmala would do nothing but potentiate an LSD trip. even though LSD is not eaten by MAO, harmala does have 5HT2 action and will change the 'color' of any drugs taken concurrently.
while i have never tried it personally, i've read that harmala + lsa is a synergistic combo for this reason. however the bodyload may also be increased, as harmala causes dizziness and nausea in most people.
to coombesy: if you are eating the harmala, most of its action will be inhibiting MAO in the gut, and thus you can capsulate ~100mg DMT and eat it 30 minutes afterwards for "anahuasca" (analog + huasca) experience. a single dose of harmala is cleared relatively quickly (6-12 hours) from the body.
i have no experience with eaten harmala + smoked dmt, or smoked harmala alkaloids + smoked dmt, but theoretically both should be a stronger experience than the smoked dmt alone. as above, harmala also changes the color of a trip.
the one combo that does not make very much sense is smoked harmala alkaloids + eaten dmt, as very little harmala will make its way from the lungs to the gut, and most of the dmt will probably be destroyed before it reaches the bloodstream.
as always, NEVER COMBINE a monoamine releaser with an MAOI, as either serotonin syndrome or a hypertensive crisis may result. personally I have eaten sharp cheddar cheese before and after harmala ingestion with no noticeable effect, but I would NEVER try a PEA or amphetamine.
