In many cases, people assume that NE plays a minor role in stimulants' and empathogens/entactogens' desirable fx. I find this unjustified. For a point of comparison, we have: MDMA (affecting 5ht, DA, and NE all to a great extent), MBDB (affecting 5ht and NE but not DA (well maybe just a lil' bit)), and MDAI (affecting pretty much only 5ht). And then we have auxiliary comparison points: ethcathinone for a relatively selective, centrally active NE releaser, and ephedrine, an NE releaser exerting severe peripheral effects. (there are other possible compounds which we could compare; the above is a bit arbitrary.)
Okay...so we can look at what type of experience NE release effects in relative isolation from other effects. Surprisingly, many people find ethcathinone a solid, mildly euphoric stimulant. We can also look at the MBDB/MDAI contrast to see what role NE plays in 'non-stimulant' (really, non-dopaminergic) entactogens. However, there currently exists no selective releaser of 5ht and DA (sans NE fx), so we can't discern what NE brings to the DA + 5ht party. Hell...there's no DA releaser with little NE activity, even.
IMO, NE likely adds greatly to the body-high and felt excitement, but also anxiety and 'crashing'.
I'll assume that you meant MDAI when you wrote "mda". MDAI + d-amp will likely more closely mimic good aspects of mdma but will exert greater neurotoxicity than the combo w/ mph. MDAI + MPH is likely only very minorly neurotoxic, or perhaps not at all.
MDAI + selegiline is a different story: since exogenously triggered dopamine release does not occur in the combo, selegiline doesn't potentiate MDAI via that mechanism. So I hypothesize that MDAI is a substrate for maob, hence potentiation when taken with an MAOBI. The underlying data? Not much. I've found that with selegiline, 50 mg mdai will yield moderately strong fx (just the right level) for roughly 3 hrs., 1 redose at like T + 2 hrs. working well. Another selegiline user on BL finds MDAI idiosyncratically potent too. Typical doses for MDAI taken alone tend to be more like 100-200 mg. But be careful: this combo is experimental, and you could be somehow highly sensitive, etc. and yield dangerously strong fx. I'd do Shulgin-esque titration with the MDAI for this combo.
ebola