great points, i made the example in another thread using 2c-e. I agree, 2.5 to 3mg is a safe, strong dose. So 100mg is 33 to 40 times that amount. Now imagine a safe but strong 2c-e dose, 18mg. A 40 times overdose of that would be 720mg, which i would imagine is anything but safe. Imagine mescaline... Let's say 400mg for a safe but strong dose (which may even be a bit low). 40 times that amount is 16 grams. I am nearly positive if you took 16 grams of mescaline amputated toes would be the least of your concerns. In fact, you'd probably no longer have any concerns at all, since you'd be dead.
I think what gets people with doc/doxs is that the dose is so low, and some people are idiots, and 100mg of a powder isn't a lot. But used responsibly, that is to say, with scales and liquid measurement to divide error, and using good dosing levels, you don't need to worry any more than you do with any psychedelic. Okay maybe there is a little more risk than 4-sub-tryptamines or lsd, but the safety margin is still more than good enough. Anyone being responsible with doc is not ever going to ingest anywhere near 100mg.