People, please start small with this substance.
I used liquid measurements because I don't trust my scale with such a small amount. After reading this thread, I weighed out 50mg, dissolved it into 10ml water/vodka solution.
I figured 10mg would probably be a good starting point. Based on the info I'd read, it seemed like a mid-range point. Strong, but not overwhelming. Perhaps even underwhelming for some. I wasn't worried about the mental component being too strong, as I felt I could handle strong mental trips, and with most reports the body load seemed to be either minimal, or very pleasurable. So I dosed 2ml of my solution into a glass of water, and drank on an empty stomach.
I was horribly wrong.
I waited, chilled out, watched some shows. I felt fine during most of the standard 3 hour come-up time.
Then it hit.
The euphoric body high most have described.
Except for me.
What I felt was intense, searing pain.
It started in my shoulders, neck, and shoulder blades (where I've had previous injury and struggle with pain that occurs more days than not) and spread throughout my back. It eventually reached into my upper arms and legs. It wasn't the usual feeling of muscle soreness or ache. It felt like fire had been poured into my body.
I lost track of time, but I know this went on for 12+ hours before I was able to finally fall asleep.
To be sure, I was tripping - I had OEVs with colors shifting around the edges of objects, definitely an altered mental state - but I couldn't focus on it or enjoy the trip. The pain was too intense. Although, I must say, the mental component wasn't anything near overwhelming. It didn't send me into an "oh god I'm dying" sort of trip, which might be expected, and I was able to mentally keep it together. I realized I just had to outlast it.
Eventually, some four or six hours in, once I figured it wasn't just going to go away, I took some vicodin left over from a surgery. 5mg, then another 5mg a couple hours later. I've no opiate tolerance, and it barely touched it. A bit later I took some MXE for the anesthetic qualities, which helped, but only a little.
It was only some 12 hours later that I was able to fall asleep and escape from the pain.
I made it though. After waking the pain had settled back to the regular chronic soreness/stiffness. It's just been more intense and persistent since.
The one good thing is that this triggered me actually making an appointment with my doctor for the chronic pain, which is something I'd been resisting doing. Hopefully I'll be able to get referred to a physical therapist who can help the underlying problem.
I don't suspect having a bad substance. Just that my body couldn't tolerate it. But I think it could have been lessened (although probably not altogether avoided) if I would have started with a 5mg dose.
So please, if this is your first time with this substance, do start small. Be cautious. My reaction seems to be quite rare, and it seems like most people have been just fine with doses similar to what I took. But just in case you're one of the rare few like me - starting with 5mg rather than 10mg just might save you hours and hours of agony.