Yeah, you can get what is called nasal septum perforation. YOu can clean your nose before and after, it doesn't matter, putting drugs up your nose on a daily bases will put a hole in your septum. There's one trying to finish the job on my septum, half way through it. I can fell a small crator, which is probably from peevee or drone. 3FMC is even worse on the nose than those two to me so you might want to take breaks from insufflating doses. People say it can't happen, but I know someone that has septum perforation from just plain o'nasal spray.