It depends on your tolerance to opioids (oxy). 30 mg of oxycodone is a lot (too much) for someone without tolerance. That Gabapentin dose is fine to combine, however I would start with 100-300 mg per dose and maybe even try it by itself first to get a feel for how it will affect you. Be aware that you may possibly experience increased sedation, and dizziness. The gabapentin in addition also may slow you down a little more.
Lovely combo, I also enjoy gabapentin with bupenorphine as wellI take pregabalin (Lyrica) 150 mg and oxy 40 mg every 2 weeks or so. For some reason the Pregab seems to smooth out the oxy high. One of my favorite combos!
I'm prescribed Oxycodone and Pregabalin and they seem to potentiate each other when taken together. Imo it's one of the best combinations for a pain condition.
When I'm in really bad pain I take 60mg of Oxycodone IR, 400mg of Pregabalin, and Ketamine. That combination provides intense pain relief which is on a different level!
I wouldn't recommend you take my dosages as you've probably got a much lower tolerance. Start at a low dose and work your way up slowly.
I wanted to state that i can vouche for this being 100% accurate. the effects of both pregabalin and oxycodone almost play off of eachother. but ketamine i haven't tried yet, i tend to try my best to stay away from psychedelics
if you and i know you may be exactly like me where at times, treating pain as quickly as possible is the most important thing in life i know this is true when i wake up and i want to remove my brain from my head with a butter knife because my pain is so bad not to mention acute withdrawal from heavy doses of pain meds usually doesn't help when waking upI'm prescribed Oxycodone and Pregabalin and they seem to potentiate each other when taken together. Imo it's one of the best combinations for a pain condition.
When I'm in really bad pain I take 60mg of Oxycodone IR, 400mg of Pregabalin, and Ketamine. That combination provides intense pain relief which is on a different level!
I wouldn't recommend you take my dosages as you've probably got a much lower tolerance. Start at a low dose and work your way up slowly.
i've been told this before, but generally speaking if i want to melt into my bed or couch and have a i unno if we can classify it as a trip but lets call it a 'trip' im sure you'll know what i mean, i'll lean toward taking more of my morphine =p but i've heard things about ketamine benefiting people with depression and what not so i assume it can even have its medicinal uses just like i use cocaine for pain oi maybe thats why the two rhyme mind = blown.Ketamine is more of an Anesthetic than a Psychedelic imo. It depends on which type of Ketamine your taking as theres 2 isomers plus Racemic, theres R, S, and Racemic. I take S-Ketamine.
that's because per say opiates, are metabolized via the liver into the bloodstream while the gabapentin/pregab are absorbed via gastrointenstinal tractsI am actually surprised that no company has come out with a chronic pain medication which is a combination of, for example, hydrocodone and gabapentin or pregabalin and/or baclofen . . . maybe medicinal chemists could find a way to make such a combo at the molecular level? Which is not to say it would be the best idea in 100 per cent of cases -- but the politics and economics in the largest markets would seem to point in that direction,
I love the story I heard today of an insurance company who was complaining about a chronic pain patient in the USA getting too many narcotic scripts, so the doctor consolidated all her narcotics into one monthly fill of 480 4 mg multi-purpose hydromorphone tablets, to usually be taken sublingually, but they she can also put on some rubber gloves, get some alcohol swabs, draw up some sterile saline into a 3 cc syringe, pull out the plunger, put 1 to 4 of the tablets in the barrel and put the plunger back in, shake for 3 minutes, and carpe diem, in the arse cheek, hip, or up the main line . . .
that's because per say opiates, are metabolized via the liver into the bloodstream while the gabapentin/pregab are absorbed via gastrointenstinal tracts
waaaait a sec, while obviously by crushing my morphine ER kadian caps i'm beating out the time release but am i getting less morphine?One of the newer things invented in the field of pharmaceutics are matrices and coatings which survive in the digestive tract different lengths of time, which have been sought as there are stark differences in absorption from the bottom of the oesophagous, the stomach, the duodenum, jejunum, ileum, colon, rectum &c . .. the differences in pH alone can be something like 0.7 in the stomach in extreme cases to over 12 further down for folks who make lots of bile, and different drugs are, as you mention, absorbed best in different places. One trick I discovered for MST Continus/MS Contin was to take some sodium bicarbonate and eat some pasta with it so the pill arrived whole in the duodenum, and it made all the difference, even when I chewed the tablet and washed it down with Coca-Cola if I did not have injectable M with me . . .
waaaait a sec, while obviously by crushing my morphine ER kadian caps i'm beating out the time release but am i getting less morphine?
somtimes your posts are written with too much smarts for me to process :/
well, i only crush my kadian and take it that way, from i notice is that, 20-40min in, it starts to kick in, but come 40-60min it's full force for a good 2-4 hours and slowly fades over about 6-8 hoursYou'll get the morphine one way or the other, of course . . . my experience with extended-release is with the wax-type solid tablets like Codidol, Didor, MST Continus, Ketodur, MS-Contin -- I think the fact that the morphine is best absorbed from a mix of the stomach and duodenum is why extended-release opioids are made they way they are, within limits . . . there are political elements and superstition as well . . . When I shit out Kadian beads on the first go back in the day, I went straight back to the doctor and that was the end of that. That is my higher gastric pH and dead spots on the lining, I think. When one of the orphenadrine ER makers cut corners and/or got too clever by half, I wound up with a bezoar of tablets the size of a cricket ball in my stomach and have been on the injectable ever since.
This could mean that an experiment with the Kadian may be to smash 50 per cent of the beads and leave the rest intact, to see if you can notice a delay then a more rapid absorption from the duodenum. I would think that it would manifest as a bigger bang, as it would be a more rapid increase in serum morphine level and therefore the absolute number of mu opioid receptors agonised over a given, short period of time.
The chewing & Coca-Cola/Sprite whatever process should be good enough for 80 per cent of people who need IR morphine in a pinch and did not get it from the doctor, but:
All of the ER formulations can be split by bench or kitchen processes into a gob to swallow which has as much or more of the extended-release effect, the colour of the tablet, and an injectable or nasal spray; describing it here may not be clear enough harm reduction to be within the Bluelight rules but it is straightforward at least. For economic sake, let me tell people to not discard the colouring on the tablets -- that colouring contains 2 to 9 per cent of the opioid dose. Suck it off or shake your tablets in šljivovica or tequila and drink it, In any case, later steps will re-sterilise the surface of the tablets.
Then the Kiwis and their followers have made some discoveries in this general department which are relevant. That most assuredly is verboten to discuss here.
I have heard multiple theories about why this happens to be the case for extended-release opioids. The one way I could imagine modifying Kadian to bypass the stomach would be to get some larger capsules and make the Kadian into the centre of a Russian nesting doll type setup.
The best extended-release mechanism is the least expensive and was invented before 1930 -- it is how they make Codidol -- they get their drug mixture, mill it into round particles of four different sizes, and encase it all in paraffin, sometimes with Vitamin C or sodium carbonate added to adjust the pH of the tablet. These Zogenix and other abuse resistant formulations demanded by politicians are a scientific and political abomination and a fundraising technique which is essentially wetting a little bird's beak as the Sicilians say: a protection racket, as many oxycodone patients have to struggle with all the time.