• 💊 OTHER DRUGS 💊 Welcome Guest
    Posting Rules Bluelight Rules
    Notable Threads 1 Notable Threads 2
    Dangerous Combos Addiction Support
    Emergency Services Benzo Guide v.1
    Addiction Stories Scary Case Studies
    Biology, Pharmacology & Drugs 101
  • Select Your Topic Then Scroll Down
    Alcohol Bupe Benzos
    Cocaine Heroin Opioids
    RCs Stimulants Misc
    Harm Reduction All Topics Gabapentinoids
    Tired of your habit? Struggling to cope?
    Want to regain control or get sober?
    Visit our Recovery Support Forums

Bupe Suboxone/Buprenorphine FAQ & Megathread v3; 2010 - 2022

Status
Not open for further replies.
Just wondering if you guys have experienced withdrawal symptoms from suboxone after 2 months, although most of the physical symptoms have gone away after 2 months i still have chronic diarrhea and really bad anxiety and depression. I guess im just scared and want to make sure im not alone.
 
methadone/percocet to suboxone switch. still have some withdrawal symptoms after6days

Hi. I recently switched from 120 mg of methadone , and 30 mg percocet , to now 12 mg suboxone ( previously was 8 mg ). I told my doc I was on about 40 mg of methadone bit then I remembered I was actually taking a lot more then that ( long story on how I got confused, but point is I was taking more then I told him ). Anyway I'm on day 6 of suboxone,you don't think I'm going threw a bit of withdrawal do you because I have severe insomnia, sweats, runny nose and eyes. I thought precipitated withdrawal was only a few hours. I also have chronic pain but can't find a pain doctor with my shitty insurance. I feel like I'm dying. Does methadone precipitated withdrawal last this long or is it something else? Would I feel better if I stopped the suboxone? Should I go to the ER or just wait it out? Haven't slept in 2 weeks, can barely type this ( so sorry if I sound incoherent I'm extremely sleep deprived.) Feel free to ask me questions. The insomnia could be from my chronic pain, the same with the waking up in sweats. However the runny nose/eyes and some nausea I can't explain..although the nausea could be from chronic pain/sleep deprivation. Maybe I'm still going threw withdrawal from methadone? I feel like I'm going to die, but hospitals keep treating me like shit and kicking me out. I will go if you think I should though. Life sucks right now. The doctors keep treating me like a junkie but I'm a chronic pain patient for 6 years now. These doctors know shit about chronic pain, they think its all in your head, fucking idiots. Pain specialists know its not all in your head, but these nonspecialist ER doctors know shit about chronic pain, they think I'm using chronic pain as an excuse to use pain meds, but the fact is I hate using opiates for pain. I tried lyrica and gabapentin but it doesn't work for my type of pain. Any chronic pain survivors here? Either way I could use everyones help. Peace :) and thanks EDIT : also my doc told me suboxone can't cause insomnia but I read reports that it can. Makes me wonder if I should stop taking it or just stick to it.
 
Last edited:
yes, you're still in withdrawals from that dose of methadone. due to suboxone only being a partial agonist, it's only filling some of your receptors where as methadone was filling all of them. it isn't advised to switch from methadone to suboxone unless you're around 30mg of methadone where as you stated you were taking around 120mg. and how on earth you were taking 30 mg percocet and even feeling them thru the methadone is beyond me. unfortunately i don't have an answer however. who knows how long this could persist and i don't believe more suboxone would help either. i would suggest possibly being honest with your sub doctor about your previous methadone dosage and maybe he has an answer. good luck
 
You have to build up your blood levels of bupe (info from another thread). It takes a while. Hang on man, maybe look into some Dxm or immodium?
 
Yeah, its weird its helping with some withdrawal symptoms, sort of, like cravings, diarrhea, puking..but besides that I'm prolly still going threw withdrawal like you guys said because I have other symptoms like nausea, cold sweats, hot sweats, runny nose/eyes, feeling weak as all hell, my chronic pain is much, much worse then usual ( probably from lack of pain killers for first time in my life. Its extreme pain ! ). Anyway this isn't going to last forever is it? Can it kill you? I mean damn I feel so close to death or I'm going to end up with permanent brain damage or bodily damage or something...maybe its just anxiety and panic attacks from the withdrawal?
 
Last edited:
RazorBladeSlide said:
Anyway this isn't going to last forever is it? Can it kill you? I mean damn I feel so close to death or I'm going to end up with permanent brain damage or bodily damage or something...maybe its just anxiety and panic attacks from the withdrawal?
Click to expand...

The latter, anxiety
You have to wait till the tolerance go down and the subuxone is enough.
Onethr idea is to go back to methadone
 
do you think bupe is better in the morning or night?

down to 4MG bupe and only take it once a day. usually take it the minute I wake up in the AM but always hear/reading how others will take it at night.

wondering what most people do? would be nice to wake up and "feel normal" rather than struggle sometimes and have to wait. the thing is, I dont know if its just a morning thing or if its truly the suboxone.
 
Why not split it into two doses, one morning one night?

That way you'll get your "feeling normal" during the day and won't have trouble sleeping at night, either (if that's what's happening).

Are you tapering or doing permanent/semi-permanent replacement?
 
I dont like doing it first thing in the morning, i want to avoid my body getting used to the time.and ritual.

How do you take it? SL?


- hopeless
 
I take my 6mg dose split into 3x2mg. However, taking a dose before going to sleep can make you sleepless. I noticed that my sleep is generally worse if I take bupe relatively close to going to sleep, it feels uncomfortable, sometimes to the point of restlessness, when you're tired and can't properly fall asleep for a few hours. On the other hand sometimes when I couldn't fall asleep and was nervous, taking a dose helped me fall asleep, I suppose it's a matter of the size of a dose.

It could be that in the morning you're already feeling not well because the levels of buprenorphine dropped, it's not withdrawal per se, but if you take it in one dose, there's a higher chance of bigger rises and drops in concentration of bupe in your blood (at receptors). It was designed to last long and wear off very slowly, but I guess just like with any drug effects differ among people. When I took one dose in the morning, it often caused too much sedation while in the evening it was already wearing off, taking it 3x2mg I'm feeling "normal", so you might try splitting your dose in 2x2mg as well and see how it works for you.
 
Last edited:
Phil.McKeer said:
Why not split it into two doses, one morning one night?

That way you'll get your "feeling normal" during the day and won't have trouble sleeping at night, either (if that's what's happening).

Are you tapering or doing permanent/semi-permanent replacement?
Click to expand...

That is what I always did. And if you get to a low enough dosage, you can really feel it even 8 hours apart. I'm merging this with the Suboxone/Buprenorphine Megathread.
 
From the Suboxone megathhread, which I'm going to merge this with:
Captain.Heroin;12702891 [B said:
Bioavailability:[/B] Buprenorphine bioavailabilities:

intraduodenal: 9.7%

intrahepatoportal: 49%

intramuscular: 68%
"The observed mean intramuscular bioavailability was 68%"
"Studies of buprenorphine bioavailability have also examined the intramuscular (bioavailability, 50%–100%)"

intranasal: 50%
"Studies of buprenorphine bioavailability have also examined the [...] intranasal (bioavailability, 48%)
"The bioavailability of buprenorphine, HCl (BPP) in sheep after nasal administration of two formulations has been studied. 0.9 mg BPP in 150 microl was administered nasally and compared to 0.6 mg i.v. The test solutions were formulated with 30% polyethylene glycol 300 (PEG 300) and 5% dextrose, respectively. The bioavailability for PEG 300 was 70% (S.D.+/-27%, n=6), whereas the bioavailability for 5% dextrose was 89% (S.D.+/-23%, n=6)."
"Mean intranasal bioavailability was 48.2 +/- 8.35% (mean +/- s.e.m.) of the intravenous value"

intrarectal: 54%
"bioavailability of the drug was found to be: [... ]intrarectal (54%)..."
"Relative to the 100% bioavailability from the intraarterial route the mean bioavailabilities were [...] intrarectal, 54%..."

intravenous: 98%-100%

oral: 10%
"the oral bioavailability for buprenorphine is state to be 10%"
"due to extensive first-pass metabolism, buprenorphine has very poor oral bioavailability (10% of the intravenous route) if swallowed"

sublingual: ~30%
"Buprenorphine is well absorbed sublingually, with 60% to 70% of the bioavailability of intravenous doses"
"Study results indicate that bioavailability of sublingual buprenorphine is approximately 30%"
"Literature on bioavailability of sublingual buprenorphine presents variable numbers ranging from. 19–58% of the administered dose."
"Relative to the 100% bioavailability from the intraarterial route the mean bioavailabilities were [...] sublingual, 13%"

transdermal: 15%
Click to expand...

IMO, rectal is second best to IV or IM I imagine (have never muscled Bupe). However it's inconsistent, depending on how backed up you are. Insufflation works well too and hits fast as well, but in the end, though it has a lower BA it seems to last the longest. If you put some alcohol under your tongue, even mouthwash, it also boosts the BA up dramatically, possibly making it more effective then rectal or nasal.
 
Znegative said:
From the Suboxone megathhread, which I'm going to merge this with:


IMO, rectal is second best to IV or IM I imagine (have never muscled Bupe). However it's inconsistent, depending on how backed up you are. Insufflation works well too and hits fast as well, but in the end, though it has a lower BA it seems to last the longest. If you put some alcohol under your tongue, even mouthwash, it also boosts the BA up dramatically, possibly making it more effective then rectal or nasal.
Click to expand...

^^^ lookin at this earlier and I read this as saying the bio for peg300, itself was 70. And the bio for dextrose %5, itself, was 5 hahah
 
WHAT drugs are safe/ not fatal, to use with bupe.

I know tramadol, kratom
What about lope? What about klonopin (been doing it and nodding for 3 days), alprazolam, a couple alcohols, cocaine? Tapendetol?

What happens if you snort a lil H on subs, nothing or WD?
 
Sup Mike. If you try to use H on are regular to high dose of subs, you will feel nothing. You might be able to crack through the "blockade" if you were using a lower dose.

I highly recommend not using full agonists while on Bupe. It doesn't cause pwd as some might misbelieve (its the other way around, H first then subs, that causes pwd) but it just blocks the H because it binds tighter. Many people die because they try to bang through their blockade with more dope, barely catch a buzz, then depress their CNS so bad they die of respiratory failure.

So choose either dope or bupe. Bupe is for getting off dope.

I think, in comparison to some other opioids, bupe is more unforgiving with other things you can mix it with, but if you are opiate naive and the bupe actually gets you high, I wouldn't mix anything with it at all.
 
Phil.McKeer said:
Sup Mike. Bupe is for getting off dope.

I think, in comparison to some other opioids, bupe is more unforgiving with other things you can mix it with, but if you are opiate naive and the bupe actually gets you high, I wouldn't mix anything with it at all.
Click to expand...

Now I'm getting tired day and nauseaded and I'm nodding all day without any euphoria (also take klonopin) - I think my dose has been too high and making me pukey
 
mike.vick said:
Now I'm getting tired day and nauseaded and I'm nodding all day without any euphoria (also take klonopin) - I think my dose has been too high and making me pukey
Click to expand...

Yeah bud if you're nodding all day and getting nausea, you don't need that dose level. Are you taking the bupe for recreation or detox or what? And what are you adding the klonopin on for? I already find bupe to be pretty anxiolytic, so if you don't NEED the klonopin you can probably cut that out easily. Unless you're doing it because you like it, of course.

Like I said, I'd understand if you're going for a buzz, but if the sub gets you high and you're trying to detox, I don't think you really need it, or at least the dose amount you're taking. People who were on full agonists and switch to sub usually don't "feel" the sub (I mean, I can tell its there, but it's not getting me high - just keeping me from having a runny nose, kicky legs, back pain, and goosebumps all day), because it's doing its job right. If it gets you high, I bet you can taper down pretty quick (like 2-3 days) and get off with little w/d.

The thing is, if you take it too long, your body will get used to it and kicking buprenorphine is reportedly more difficult and drawn out than full agonists. Just a caution.

Edit: And to correct what I said in my last post, I meant to say bupe is MORE FORGIVING with what you mix it with (as a partial agonist/modulator, it is more resistant to fatal resp. dep. which is the mechanism behind opi o/d).
 
Status
Not open for further replies.
Top