There are numerous examples involving varying dosages. I am also including cases where subjects seemingly lost voluntary control, rolling around, knocking over furniture, or becoming violent toward their surroundings. This tends to occur without the subject having a recollection of it afterwards (this could simply be a sign of overdose). Panic attacks following use are also seemingly common.
From Thikal:
"(with an unknown but large amount, smoked) I observed the subject pass very quickly into an almost coma-like state. Within seconds his face became purple and his breathing stopped. I pounded his chest, and breathed for him, and he seemed to emerge in consciousness, with the comment, "This is absolute ecstasy." He stopped breathing a second time, and both heart massage and mouth-to-mouth resuscitation was provided. [...]"
From Erowid:
http://www.erowid.org/experiences/exp.php?ID=16441
http://www.erowid.org/experiences/exp.php?ID=5302
http://www.erowid.org/experiences/exp.php?ID=2235
While these may have involved overdoses, a human LD50 for 5-MeO-DMT alone is unknown and may be much lower than the figure extrapolated from rodent data. Both 5-MeO-AMT and 5-MeO-DIPT have been implicated in fatalities. It is also likely that some people have unusual sensitivities to this compound which result in what would be a "typically transcendental" dose becoming a toxic one. In contrast, there seems to be many people who respond quite well to this drug at huge doses.
Just be careful and start real low. I certainly wouldn't recommend more than 5mg orally with any MAOI. Actually, I'd say start with 2mg and go from there.
No one should have to endure my own aya + 5mg experience.
From Thikal:
"(with an unknown but large amount, smoked) I observed the subject pass very quickly into an almost coma-like state. Within seconds his face became purple and his breathing stopped. I pounded his chest, and breathed for him, and he seemed to emerge in consciousness, with the comment, "This is absolute ecstasy." He stopped breathing a second time, and both heart massage and mouth-to-mouth resuscitation was provided. [...]"
From Erowid:
http://www.erowid.org/experiences/exp.php?ID=16441
http://www.erowid.org/experiences/exp.php?ID=5302
http://www.erowid.org/experiences/exp.php?ID=2235
While these may have involved overdoses, a human LD50 for 5-MeO-DMT alone is unknown and may be much lower than the figure extrapolated from rodent data. Both 5-MeO-AMT and 5-MeO-DIPT have been implicated in fatalities. It is also likely that some people have unusual sensitivities to this compound which result in what would be a "typically transcendental" dose becoming a toxic one. In contrast, there seems to be many people who respond quite well to this drug at huge doses.
Just be careful and start real low. I certainly wouldn't recommend more than 5mg orally with any MAOI. Actually, I'd say start with 2mg and go from there.
No one should have to endure my own aya + 5mg experience.
