I've wondered about what exactly is physically involved in drug absorption through various ROAs. Why, for instance, is MXE reportedly more potent both rectally and orally than intranasally (certainly far more potent rectally)? With ketamine, the opposite seems to be true, with oral and rectal administration being roughly equivalent in terms of subjective potency and intranasal being more potent then either.
I second the notion that thinking plugging must be motivated by some homosexual motivation is juvenile (though that's fine, too, so far as I'm concerned). Regardless of that, what the fuck kind of man is so afraid of his own asshole that he can't use it to his own advantage? Oh wait, we can just look to this thread for the answer to that.
