Opiate Tolerant People please enter : looking for someone to out tolerate me.

[belligerent drunk]

I second what everyone has said in the meantime. It might be a good idea to look for higher efficacy opioid agonists, because maybe plain morphine or similar just aren't strong enough. Fentanyl and analogues are famous for being very potent, but their duration may leave you dissatisfied. Oxymorphone sounds good to me.

I would also like to say that, despite your tolerance, I don't think anybody is immune to overdose. You're combining opioids, NMDA antagonist, and benzos. The risk of overdose from a single agent is usually fairly small, but if you're taking 3 different classes of downers, then you're treading dangerous waters. So keep that in mind.

 

[SKR]

I can't help but feel your Dr's are placing bets in the lunch room on which day you're going to OD, ask 'em what the pool is currently at lol. Joe I'm sorry you're in this shitty situation. Did you say 2mil in debt?! You're in the US then huh? I'd be really interested in how you ended up where you are today health wise but you would have shared that already if you had wanted to. I think you obviously need to mix up your opioids as others have suggested maybe the 'morphones could offer you better relief. They should try diamorphine too (Heroin). Don't spose a guy with a 2mil debt can buy illicit drugs?

For me there was definitely only so far oxycodone could take me. I'm the same age as you Joe, I'm in chronic pain and I ended up on doses up to 500mgs per dose but once I became tolerant to doses in the range of 240-300mgs and by tolerant I mean I couldn't "feel" the drug no euphoria or sedation or noticeable pain relief. In fact, I took 600mgs a couple of times (which was stupid despite my narcan ampules at the ready) and I didn't really feel much if anything more than 300mgs.....that's some serious diminishing returns, the drug became useless to me. So I opted out and am now on suboxone as an opioid replacement (shit pain relief due to my tolerance unfortunately) but I'm considering my options again with full agonist opioids but I've got other health concerns that I need to get sorted out first.

I hope you find something that helps you Joe, as previously mentioned, check out the pain management thread we're a supportive community inside of a larger supportive community. Take care

 

[Crack'r]

This is what I was going to post yesterday then read some of your other posts and wasn't sure how helpful it would be?:

------

Are you positive of those dilaudid numbers? At that rate you shouldn't feel oral morphine at all or most other oral meds.

Does the lorazepam make you sleepy at all?

I have never taken ketamine and don't know dosages. I do know it's used every day in surgery to help knock you out. Sounds like it may be on the low side except for the hallucinations?!

It sounds like you may have some type of nerve disease? If that were the case it may be that opiates don't respond in the same way for you? Regardless, I'm very sorry about the situation you're in!

I wasn't an IV user so my numbers won't really compare. I plugged everything and found dilaudid did about as much as oxycodone which after a decade wasn't much for pain. I took 120 mg at a time usually and around 4 times a day but sometimes 6 times if it was a bad day. But occasionally I would try to get a buzz and take around 500 mg plugged and would still not feel much though it did seem to finally knock my pain out for a bit. If I took 3-6 mg ativan, depending on how much I had been taking recently, this would start to make me nod a bit but it was more a sleepy thing than euphoria. Without it, just the opiates didn't do much. Trying to get a buzz was probably the worst mistake I ever did from a pain management and tolerance point of view. Like you, I suggest no one take an elevated dose to try and get high if they have legitimate pain. And I only did it every couple months, it was not a routine thing I did.

I also found plugging to be 2-3 times the strength of orally taken meds. Maybe more. I would try taking that amount orally and never reached an equivalent amount of pain relief which really was just taking the edge off and never relieving it. I would take it orally to see if I could get away from plugging but it never helped so I just kept plugging away. I think once you get to a certain point opiates just stop becoming effective. And my plugging was just an attempt to get the most into my blood. With a port you don't have to worry about that.

I would be curious to know if subutex or methadone provide much pain relief since they bind so tightly to opiate receptors? Have you been to a hospital, preferably a good size teaching hospital on a university campus or even NIH in D.C.? Seems like they might have more experience with pain control in high tolerance people or in regards to your situation? Or maybe (partial) sedation could help for part of the day when things are worst? Maybe a consult with an anesthesiologist could be helpful? Surely they have something in their bag of tricks to knock you out for a while?

I wish you the best of luck finding some relief and with your situation. You still sound very alert and well spoken for the meds you are on!

Have tried some of the other meds that are more for nerve pain? I think Lyrica is of this type? I guess maybe the ketamine is a stronger version of this as they are GABA effecting drug. Sorry if I don't know the correct terminology. Also what about some of the muscle relaxers? I know there are some more effective for skeletal pain or nerve pain.

-----

Without knowing exactly what you have and the cause of the pain it's hard to know what kind of pain you are having, though I'm not a Dr so not sure how much that would actually help. But I would be interested because I do have lots of contacts in the medical community.

I'm not sure how ibogaine really works or if anyone does. But if it is really like hitting a reset button maybe it could somehow lower your tolerance? It isn't legal in the US though and you would have to go to either Canada or Mexico and finding a clinic to actually give it to you may be hard. Maybe it can be sourced illegally? Any family members need to go out of country? From what I understand it does require a day of hallucinating at effective doses. I would also be curious if maybe other countries may have treatments that aren't approved of in the US but I don't know how you would find this out? I'm getting into grasping at straws territory here.

I'm actually turning 37 today. I have been dealing with a rare and very rare blood diseases for going on 13 years. I know what it's like to deal with Dr's. Usually going to big medical centers are discouraging as many doctors are fairly negative and don't know the power of optimism. Most I have seen want to try and cure me which means a very risky bone marrow transplant that I know in my heart will kill me. They don't understand I just want help dealing with symptoms and keeping it from killing me. But occasionally you learn valuable information even if it's overall a depressing visit. One of my diseases is considered in remission although it still effects me some but has come back 4 times which is a month in the hospital getting a treatment that is hard on the body. I did learn something about a drug that seems to be keeping me from having it return so that was possibly a life saving piece of the puzzle for me so it can be helpful.

It sounds like your disease may be as rare as one of mine or even more so. I've been told there are about 200 to 300 people in the US with my one disease. So information about it is hard to come by. But there are some specialists in the country it's just the problem of finding them and getting there to see them. I would really suggest contacting NIH in D.C. as they are a government run institution. That would probably cause a sane person to run screaming but they have researched everything at some point. There may be someone that knows about your disease or someone that specializes in pain patients with astronomical tolerances.

Also has anyone every suggested a pain pump that is installed in your body? Or some type of block similar to an epidural that woman receive for child birth? My wife had one and couldn't feel anything from her boobs down and actually had to be told when to push because she couldn't feel the contractions. Or the extreme amount of tearing that occurred. May be too much info but if she couldn't feel her insides being ripped open I can't imagine it not working for you? Again, just trying to come up with something and why a consult with an anesthesiologist could be helpful. My wife is a nurse in the operating room of a level 1 trauma hospital and blocks are a routine part of pain control for surgery.

I know what it is like having to deal with illness, though not to your extent. I also know what it's like to deal with doctors that are negative and also what it's like to find one that is optimistic, with good bed side manners, and that is willing to experiment with potentially off label use of meds to try and find something that works. I wish you could find one of those but I know it's not common. If you would like to msg me and talk or give me some of your main medical conditions I would be happy to ask around about a potential specialist. My good Dr even gave me his personal cell phone number so I can contact him with any issues. He also worked at NIH for many years and has many contacts across the country as do many other doctors I have access to. It can never hurt to ask around even if it is a long shot.

I wish you the best of luck and hope you can find something to give you strength and to help deal with your situation.

 

[Crack'r]

After talking to my wife, I would really suggest looking into some type of block. She said a catheter to your spine can be installed that gives access similar to a port and a block can be installed indefinitely this way. She said there are different kinds with different meds but I imagine there has to be something that at least helps. Again, an anesthesiologist is probably who you need to talk to.I also read that people can still get high when taking subutex. To me this would mean you can still get pain relief. Since it is longer acting and tightly bonds to opiate receptors, maybe it would help satisfy your bodies high tolerance but allow pain relief when combined with other opiates? I'm just guessing here as I have never taken it to know what it feels like. Or possibly methadone? I know it is used for pain and maybe since it's so long acting it would give you enough of a base where your other meds could start to give some relief? Again, just guessing.Would also be curious if anyone thinks an ibogaine treatment would allow lower amounts of pain meds to be more effective if it really does act like a reset button for tolerance?From my own experience with pain meds losing effectiveness, I think I would look at something besides opiates, such as a block. If it somehow worked and was more effective than the opiates, I would hope a Dr will give you subutex or similar so your bodies cravings for opiates are satisfied because just your bodies need for them can be painful and mentally crushing and many people say they actually feel normal again without the intense cravings your body and mind develops.Please message me if you can. I would really like to know a bit about your diagnosis and to ask around and have my wife talk to her doctors at the hospital, if you don't mind!

 

[tightlywound]

Oxycodone.

better than morphine ime.

I have taken up to a gram a day of it, and am now prescribed 120 mgs a day fo it but take up to 500 mgs, think i outtolerate you bud.

Also snort some H when the oxy runs out, almos medical grade H.

and am on 2 mgs loprazolam for sleep.

I think that the hospice patient purportedly on over a gram and a half IV hydromorphone plus morphine daily still out tolerates you by far "bud."

 

[JoeDobbin]

Oxycodone.

better than morphine ime.

I have taken up to a gram a day of it, and am now prescribed 120 mgs a day fo it but take up to 500 mgs, think i outtolerate you bud.

Also snort some H when the oxy runs out, almos medical grade H.

and am on 2 mgs loprazolam for sleep.

I have a few questions, but don't just compare my morphine to your Oxy. Look at all the opiates that I am on:

Morphine:
20mg/mL
3mL per Hour
72mL per 19 hours (I don't take it the 5 hours I try to sleep)
1368mg of Morphine per day.

This alone, blows away your Oxy by volume. Yet, not all drugs are equal. If I go to an Opiate conversion calculator, conveniently, 120mg of your Oxy is equivalent to 1440 of Morphine oral. 1368 is less than 1440 no doubt. Yet, as indicated on my post - Morphine is just the side drug I take. The Hydromorphone (Dilaudid) is the killer, and where most people cannot compete. Lets break that down for comparison:

(corrected mg from mL on original post)
- Delaudid 40mg:1ML mix Pain Management Pump
-- 36 mg per Hour basil rate
-- 44 mg bolus rate (10 minute time separation / 6 times per hour); average 2 bolus pushes an hour over a 24 hour period (including sleeping time, etc.)
-- infused through a portacath

Since this is pumped into me 24/7 through a port-a-cath, using the last cartridge's statistics, here is how it comes out:
36mg basal x 24 hours = 864mg of Hydromorphone IV
2 bolus pushes per hour = 12 over the course of 24 hours. Each bolus push is 44 mg; 44mg x 12 = 528 mg of Hydromorphone IV.
... Adding it up 864mg + 528mg = 1392mg of Hydromorphone for the day.

Again, all drugs are not equal. Considering Hydromorphone is something like 40 times stronger than Oxy, it is an average for conversion rates. 1 MG of Hydromorphone is equivalent to about 17mg of Oxy. For giggles, my total "Oxy" conversion count when you add both the Hydromorphone and Morphine comes out to (18560mg + 1392mg = 19,952mg) on a daily basis. "Bud". %)

Thats why I was looking for people who could possibly be immune to Opiates like I possibly am.

 

[JoeDobbin]

I'm sorry that you're going through this, but I still don't understand what kind of help you're looking for. From what you're saying, it seems that you are in need for opioids, which you are getting. There really isn't much somebody over the internet can suggest, especially if you're honest with your doctors and are getting appropriate treatment.

While I can sympathize with your situation, and it is not my call to close the thread, there are certain guidelines which are in place to ensure a certain quality of posting, and posts such as yours may be better suited for the Blogs section more.

Again, I'm sorry that you're in this situation, but if you could state the question/issue more clearly, then maybe more people would be able to help.

E: as I said in my previous post, opioids are the number one class of drugs against pain, and you're taking astronomical quantities of them. I can't imagine what could help you alleviate the pain you're suffering through, except maybe cannabis or a gabapentinoid (gabapentin/pregabalin etc).

I was actually looking for the opposite. As in my previous post, I consume nearly 20k mg of Oxy a day of opiates. The doctors only want to continue to increase the dosages. I was looking for advice from people that are Opiate Tolerate or better yet, Immune, like I feel like I am. The doctors are generally just as confused as I am on how to treat my pain. Right now, I am essentially in a standing order of sedation to control pain.

I don't want to sleep the rest of my life away.

I don't know if there is a miracle solution out there or not for me. Yet, the Ketimine option came from this forum on a thread of mine, asking for potential other drugs that could provide some sort of relief. That was a great suggestion, one to which my doctors took up quickly too, once researched. So.. here I am again - looking to throw another hail marry pass and find some sort of substance to give me some relief!

 

[seahawks168]

I think im pretty tolerant... Just downed about 200mg oxy today... Now about to redose 7 hours later. Kind of ashamed to be honest... But anyway, try getting fentanyl... Thats rly the only advice i have, and the only opiate that may be able to provide some relief

 

[JoeDobbin]

... I deal exclusively with psychiatry issues, practically nothing involving pain management other than the incidental psych patient who is on PM elsewhere prescribed. this is why I will give you no numbers as follows. I would humbly suggest:

your tolerance is indeed astronomical, so you can take pretty much about anything it seems

d/c p.o. morphine, just forget it; substitute oxycodone or probably better yet oxymorphone
consider fentanyl as better baseline opiate (i.v. since you have it; other RoAs to be considered) wit
large dose dilaudid or i.v. morphine for breakthrough pain
phenergan is possibly worthwhile as a potentiator and will help with any nausea
neuroleptics will help knock you out but you won't like them
ketamine seems to be working for you but the hallucinatory qualities seem to trouble you. as many rec users may tell you, you will develop a tolerance or an ability to function on hallucinogenic quantities of ketamine
ativan can go up, there is essentially no ceiling to any of these drugs given tolerance
lyrica/pregabalin probably won't work if your pain isn't neuropathic but why not, it's worth a shot, it will also potentiate opiates

have you tried marijuana/Marinol™/high-potency medical cannabis products? is it legal where you live? if not, it's pretty easily soured and if your hospice team is this liberal they will probably at least turn a blind eye. if ketamine is causing you significant psychological distress though marijuana is likely to do the same in therapeutic doses which I am given to understand are rather large (thus the exotic high potency products out there), but it's at least worth a try probably although I'm generally canna-skeptic.

I don't think I can provide better advice than your hospice team though, nor can most if not all Bluelighters. I'm just throwing things out there; nothing I suggest is particularly novel or out of the box.

You may get some people in their suggesting esoteric research chemicals and the like, I'd ignore them and perhaps not appreciate the posts; however, on the other hand, if you're in an "anything goes" situation, it might be worthwhile, if there is a genuine justification. there's probably not as almost all of the commercially available ones are just variations on already available themes

Thanks for your reply. For the ease of reading, I removed the full disclosure and completely understand anything you write is suggestive to my basic information provided on this anonymous forum.

Prior to moving to Hydromorphone (Dilaudid), I was on Fentenyl. Bottom line, Fentenyl is too expensive. I was spending $40k a month on drugs like Abstral and SubSys for the quantity (1200mcg, 6 x daily= 300 doses a month). My Co-pay of the Abstral was $1,000.00 a week; we did this for four months before we had to find another solution.

I will say, Fentenyl did seem to work wonders compared to everything else. Yet, I also believe Fentenyl was the drug that destroyed my tolerances. Phenergan works wonders for nausea and vomiting, but it does knock me out. We tend to go to it when I am really bad, in a lot of pain, as it will quickly subside any vomiting feelings and make me sleep near instantly. The only issue is, is that even 1/2 mL of it will keep me knocked out for a good 12 hours or so.

It is a common fight here.

Pain vs No Pain with side effect
Sedation vs Coherent
etc.

I am not trying to be unreasonable and expect to be cured. Rater, what I am coming to these forums for is for tips like this (even if I have already tried them) because occasionally there may be one that I have not... for example, Cannibus.

I live in a non-cannibus friendly state, and my efforts in getting some through friends have failed. I don't really feel that comfortable, having my wife drive me down to a bad area of town and randomly select people and ask for drugs. So much could go wrong here..

 

[JoeDobbin]

Maybe I missed it but you still failed to say where you live. That is relevant.

Also, consider writing shorter posts. It's paradoxically easier to understand what you have to say when you keep it succinct.

I'm not trying to be unwelcoming, but just like everyone else who has posted I was unclear on exactly what you were asking.

I still recommend cannabis, just like I did 1 year ago. Opioids are not effective for neurological pain.

Sorry - Kansas - USA.

Both state and federal do not support cannabis.

 

[JoeDobbin]

Unfortunately I don't have any answers for your questions, but I do have a family member with a similar problem (but her pain issues have mostly passed fortunately).

SERIOUS WARNING:
Do not think that because you have an astronomical opioid tolerance or because you don't feel your pain medications that you are immune to an overdose. Even if you dont feel your pain meds working. Said family member of mine overdosed in a hospital of all places as doctors continuously administered pain meds trying to get her pain under control. She had no history of recreational drug use of any sort--she simply didn't respond to opioid pain medications. However, the CNS depression still occured.

I didn't mean to be harsh or anything, but it's an important consideration. I hope you find something that works for you. Thats an extremely difficult situation to be in.

I appreciate your wisdom here. When I first came onto Hospice, I spent 5 days within their Hospice Bed care; the purpose was for this exact reason. We are dealing with powerful medicine and didn't want an OD to end my life earlier than it already is. Two points though that come to my mind:
1) Political post with insurance. I only "get" 10 days of in-house Hospice care due to my insurance rights. I have spent have of that for reason of "fear" of OD only. I have to be extremely selective now, when I am feeling extremely bad or having heart issues on if they would admit me. Tough situation to be put in.
2) CNS Depression is my #1 worry. I have tried to mitigate it as much as possible:
- sleep with an air machine at 2 lbs
- sleep with a o2/heart finger reader and alarm

The alarm/reader is kind of cheezy, not like the hospital setup. It was the best I could find on Amazon under $300.000

 

[JoeDobbin]

Hi OP, I'm sorry to hear you're in the state you're currently in, but at least you are receiving adequate medical care. A couple points:

1. The mods are not trying to be antagonistic towards you, there are certain rules that they have to abide by. I've found that they are all very friendly and fair, and that we can, with a little bit of care, increase our post quality and abide by the rules without compromising the information content and what we get back from the interaction in the thread.

2. The only thing that comes to mind is adding cannabis to your treatment regime. You might not want to smoke it (it really is a terrible ROA). Eating THC containing edibles is probably going to be the best route for you, since it does not require you to combust and inhale burnt plant material and lasts longer and hits harder. Cannabis will also potentiate your opioids (although I'm not sure if "potentiate" is the correct term for this).

3. You can also use some other substances to potentiate the opioids you're currently taking, including diphenhydramine and DXM, among others. IME diphenhydramine is the best potentiator of opioids after cannabis (but again, I'm not sure if potentiate is the correct term for what cannabis does to increase the effects of opioids, but you get my point).

4. I also second what another BL'er mentioned about discontinuing the morphine and replacing it with oxymorphone.

Thanks for the two tips.

RE: Morphine - it was a drug I had never taken in my history of drugs and was hoping I would have some level of success with it. I had been on Oxy before, at high levels - and it was a throw at the dart. I will ask to go back to it. - see! A change I will make from this thread. Thank you!

Re: Cannabis - I already mentioned about that... ???

-- Finally - I am trying to get to reach response. It is taking me some time, due to the holidays and random commotion.

Thank you

 

[a222a]

https://en.wikipedia.org/wiki/Opioid-induced_hyperalgesia

 

[Keif' Richards]

I apologize up front - emotions are high as I am in a lot of pain.

I am not old. I am 37, have a wife and two kids (7 and 9). I figured I would go create an anonymous post on a recreational drug user forum, whereas the intent was to to help actually educate without any prejudiced. I thought the user community here may have some base knowledge or experience that I could actually get educated on.

Honestly, I feel that because I receive medicine through an RX that I am being kicked to the curb here. It took me 45 minutes to write that little bit of information, and I am being threatened to have the thread closed based on value not measured from I - the person who initiated the attempt to get information or help? Yeah, I already said I am emotional and that got me to use another 1/2 box of tissue. It is hard to reply to your questions (Monk) when I feel totally unwelcome and perceived stupid.

Yes - I have asked my doctor and their team.

I am in a situation where the doctors don't have answers or drive suggestions. The whole reason I am on Ketamine is based on a post I created here, had an intelligent conversation with another person, who recommended it for the 'said medical reasons. It was great advice, and moved the support for my case much further that nearly 2 million in medical bills have thus far...

I am sorry - I am angry and think it is easier to just go ahead and end it.

My intent with this thread was to find other people who are essentially opiate tolerant to the point Opiates don't work for them anymore (which is where I believe I am) and to see what they do to continue to survive. I was trying to compare my high amounts of opiates to anyone else who would post their amounts to show they were in the same realm as I - and what information followed I could glean on and try to continue to survive.

Else, it takes hours for me to write a book about the various medical problems that I have, the 34 different RX medicines that I take, the background/nature of each doctor and procedure I have had and interact with - only for someone to maybe find little value in that and closing that post down as well?

Yeah, I am on hospice. I am in the drivers seat. I essentially have an unlimited RX pad and can get whatever I want as long as it actually has a medical application. Why? The doctors are tired, lazy, or have given up on me as well as everyone else in the world. Take for example:

Two days ago I was vomiting and hadn't eaten in two days. Hospice comes out to see me as their scheduled to do, and I feel near death. Full of pain, nausea, vomiting, dry, etc. They said I look bad and called the doctor. Waited an hour for him to return the call. Asked me what was wrong, told them the issues, they gave me some Ondastat that I already had been taken (sublingual). Pain had still been high, and the doctor increases the bolus for the button push pump from 40mg to 44mg. I tell them it was a waste, as I can do 40 - with a nurses clinical 40 right after, wait 8 minutes, do another 40mg and have the nurse do her clinical on top for another 40 (160mg in 10 minutes of delaudid) and it does nothing for me. Yet, raising my bolus from 40 to 44 was the answer to my problems?

I asked for fentaghin or whatever its called, so I can IV it with my port. This would prevent my nausia and knock me out. I then tell them that the ketamine has been the only drug that makes a difference in physical feeling - and they go from 150mg /3ml a night to 3ml three times a day.

See the pattern here? I tell them - they do.

Please don't take a forum post that took me hours to write, and close it down because YOU didn't see any value to it?

I dont have the magic questions but need help. I can barely move my hands and fingers to write, nor see as everything is blurry as shit. What I would like please:

- Any recommendations of any medicines that will make pain go away.
- Any recommendations for any enhancing medications to take with already prescribed medications to make the more powerful.
- Any recommendations for any drug to alter my sense of reality of a short time being, maybe allowing me to bypass time when things are really bad?

Thats all I got at this point.

No respectable BL'er is going to discriminate or devalue your thread because you're not a recreational user. Although the forum by its nature tends to cater to us recreational users (or it may seem that way). Our primary goal is to spread the influence of Harm Reduction philosophy. I guess when you have a prescriber or are in Hospice like yourself, the assumption might be that your medical team are the ones mitigating harm for you. If you're just a recreational user, especially in a place like the United States, the only way to get information and advice it seems is from other users.

Trust me, we feel for you. Your Doctor will always have the final say, so all we can do is speculate, roughly. Opioid rotation is common as although Opioids share cross-tolerance, this cross-tolerance is often incomplete which can lead to certain medications providing more pain relief than an equipotent dose of the current medication. Luckily, there are tons of different Opioids out there.

From where I'm standing, it seems that you are already fairly heavily medicated. Opioids and Benzodiazepines taken in conjunction and at the dosages you are reporting should be enough to give you a good deal of relief, but obviously it's not doing the trick.

Have you ever tried Pregabalin (Lyrica)? It's typically prescribed for other conditions like fibromyalgia and general neuropathy, but I've found it to be useful as a pain reliever in its own right and as a matter of fact, my surgical team suggested it as an adjunct and I don't have any othe above specified conditions.

I know others have already broached this subject, but I really can't help thinking about Cannabis. It's a miracle drug for so many different conditions, it should not be overlooked. Not only can it mitigate your nausea, it might actually make you want to eat and eating a good meal could make you feel a lot better.

I know I'm really reaching here. I'm not a Doctor and don't have any experience with this sort of thing so please take everything I've said with a grain of salt.

 

[Felonious Monk]

Sorry - Kansas - USA.

Both state and federal do not support cannabis.

I assume you can't travel, or I'd say spend a weekend in Colorado to see how you respond to cannabinoid therapy. It truly is an incredible medicine, particularly for neuropathic pain. It's so inhumane that medicine is denied to people based on borders.

 

[aces99]

Hi JoeDobbin, I have been trying to send you a PM but it says your mailbox is full. Hit me up when you can so I PM you.

 

[Burnt Offerings]

I assume you can't travel, or I'd say spend a weekend in Colorado to see how you respond to cannabinoid therapy. It truly is an incredible medicine, particularly for neuropathic pain. It's so inhumane that medicine is denied to people based on borders.

Yeah, Kansas is definitely a reactionary state too, in terms of cannabis law. I feel for ya OP

 

[JoeDobbin]

Hi JoeDobbin, I have been trying to send you a PM but it says your mailbox is full. Hit me up when you can so I PM you.

Try now.
Thanks,

 

[aces99]

Ok I sent it. I think what JoeDobbin is looking for is some feedback from people that are on HUGE doses of opioids and have very high tolerance but have found a cocktail that works and get pretty good relief. Atleast that's what I think he is asking. It sounds like he is at his wits end and is looking for something that might work for him. Which I totally understand where he is coming from. Nothing is worse than waking up and being in pain all day. I think there is great value in this post and maybe someone will give him an idea that will work for him. Have you tried methadone or fentanyl. That might be an option if you haven't tried them. If you have tried both of them I heard there is another drug that is way way more potent than fentanyl, but can't remember the name off hand. But your doctor should be able find out what the name of it is. I hope someone gives you an idea that will work for you. If you need anymore information let me know.

 

[Koblih77]

Hi
I am sorry about your situation. I've been having some heroin addiction problems and my whole life i have been having problems with my tolerance towards all kinds of drugs. Especially class A drugs. I always needed up to 3-5 times more than other people which is dangerous, annoying and expensive at the very least. I still dont know what is your actual problem but let me tell you this. My father is suffering from Multiple sclerosis and he is in late stages now. He has been dealing with many unpleasant things and extreme pain is amongst them. One of the very few things that actually help him with lots of things is marijuana!!! It is good for many things and with many terrible illnesses and difficult conditions it is the only thing that helps considerably!!! Would recommend that for sure!!! As i said i dont know your circumstances or your goals but let me tell you this. Once heroin stops working due to high tolerance there is few things one can do. Switch from number 3 heroin to number 4... Find a good N4. I recommend gray heroin. From my experience it is the best one i ever had. Also if you want to take heroin and want something that will boost the effects go for methadone. I really like methadone. if you take heroin after methadone.. You only need little bit of heroin cause methadone makes it work 2-3 time stronger. But that's not why i like it so much. I had pretty bad withdrawal symptoms episode once and one of my dealers brought 200ml of methadone to me and said 35ml will be enough. It was not. But after some time i learned that my dose to make it work is at least 60-70ml and after i drunk that i felt... Well i felt sober and normal... But as i haven't been sober and normal for so long the feeling was so intense i became very keen of methadone. I believe it is a good tool when you want to kick your habit for good. I am on subutex atm and it is helping but not as good as methadone in my personal experience. Otherwise for pain tramadol i heard works pretty good. Also i do recommend to use small doses of LSD and DMT!!! It could help you with all kinds of things.. With lsd either start microdosing. Which is essentially lets say 1 regular blotter split into 10 for example and u take 1 a day and it should help you subconsciously with your mind and perception. I believe it but havent tried it. Also you can simply buy few regular trips (about 1000--1250uq i think) and split it on 2 or 4 ... And take 1/4 or 1/2 a day and that would at least make you feel better About life. Maybe even help you realise something important or simply change your point of view in a way so that you'd be happy or at least content. I have learned that i am addicted to drugs mostly heroin, crack And weed... But i am that kind of addict that i can take anything.. As long as it fucks me up.. But these 3 drugs i think i have an actual physical and psychological dependence. And i tried to quit 1000 times.. And it seems that i am to weak to quit on my own. So i have decided to got vietnam to do volunteer work. I need to get out of here or heroin and crack will be the end of me... So here are some ways and things that might help. Sorry i couldnt be of more help.
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