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Novel dissociative 3-Fluoro-2'-Oxo-PCPr

roi

roi

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Sep 2, 2013
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2-(3-fluorophenyl)-2-(propylamino)cyclohexanone.png


Other names could be Fluorophencylaminone, Fluorodeschloropropylnorketamine, 3-Fl-2-DCNPNK. FDCPNK in short?
 
All I see is "PCP"........ lol. Interesting, I know quite a few will be watching this.
 
@adder What's your take on this one? I can only find the synthesis of meta-halogenated arylcyclohexylamines, but not much else.
 
Rossak said:
All I see is "PCP"........ lol. Interesting, I know quite a few will be watching this.
Click to expand...

That's PCPr... Pr being short for Propyl, so it's a chain, not a ring like in PCP.

In other words they were going for structural similarities to Ketamine and MXE.
 
Hodor said:
That's PCPr... Pr being short for Propyl, so it's a chain, not a ring like in PCP.

In other words they were going for structural similarities to Ketamine and MXE.
Click to expand...

No, not ketamine. The halogen is in 3 position on the phenyl ring, and not on the 2 position like in ketamine. Considering NENK there's a strong indication that the latter would be inactive. The only structural similarity of this one to ketamine is the 2-oxo, so this one will probably be more a MXE or O-PCE type dissociative - if it's any good at all. I think PCPr was supposed to be more sedative than PCP and PCE btw.

I wonder why they didn't make the 3-MeO instead of 3-fluoro? imo that would have been more promising.
 
It's the first PCPr analogue in possibly decades, however I doubt that N-propyl will be very different compared to N-ethyl in both potency and effects, should be quite close.

The big unknown is the electronegative fluorine at the meta position. We know that halogens at the ortho position (ketamine, fluorodeschloroketamine) greatly reduces potency. But so does a ortho-methoxy group as well (methoxyketamine), while that doesn't appear to be the case at the meta position at all (3-MeO-PCE and 3-MeO-PCP are not far from PCE/PCP potency).
 
2-FK is rumored to be more effective than the ortho-methoxy or even ortho-chloro counterparts, despite them all sharing relatively similar electronegativity.

So OP is correct to assume we will be dealing with something similar to the 3-MeO homologues, and perhaps at an even more appreciable level.

I disagree that the lengthening of the alkyl chain will be negligible though. I think this this will require amounts closer to 2-oxo(2-chloro-PCM) than to 2-oxo(3-MeO-PCE).

I'm still waiting for the PCiP derivs to arrive. Those are projected to be superior to any other N-substitution, if only by bonding affinity - I have no knowledge of efficacy there.


Also, Roi, it's so saddening to see someone like you, with great potential, to be so adamantly devoted to the indirect downfall of our little world. I know it's a bit hypocritical of me to say the following, but if you choose to respond to this portion of my reply, please do so via PM. I'm only doing this in the thread because I'm on a mobile device and my PM functions aren't working correctly.
 
Is this one available?. Any speculations in potency and duration?

3-fluoro-2-oxo-pce could be a decent MXE analog too
 
Incunabula said:
No, not ketamine. The halogen is in 3 position on the phenyl ring, and not on the 2 position like in ketamine. Considering NENK there's a strong indication that the latter would be inactive. The only structural similarity of this one to ketamine is the 2-oxo, so this one will probably be more a MXE or O-PCE type dissociative - if it's any good at all. I think PCPr was supposed to be more sedative than PCP and PCE.
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No that's PCPy unfortunately! It was said to have barbiturate like sedation. Sounds very nice but r was stimulating.
 
My substance has arrived, i will shortcut it with floxy. What do you think is a good starter dose? Does someone knows for 2-oxo-pcpr? Should nearly be in that range, probably a bit lower in potency...ergo a little bit higher dosage
 
Why don't you titrate from really really low without redosing that same day (tolerance would screw it up), always a smart idea but here it's different enough from other known-well-enough compounds to just be safer rather than sorry. Being among the first to try it carries with it some risks and conditions, including not being impatient. I get it if you don't start at 1 µg but trying to start at the dose range you guesstimate it being active at is really stupid.
 
roi said:
It's the first PCPr analogue in possibly decades, however I doubt that N-propyl will be very different compared to N-ethyl in both potency and effects, should be quite close.
Click to expand...
Actually 3-MeO-PCPr was commercially available for a brief period of time alongside 3-MeO-PCPy and the first batch of 3-MeO-PCE from the UK. This was in 2011, I think.. 3-MeO-PCPr was indeed almost indistinguishable from it's N-Ethyl counterpart in it's qualitative effects as well as the dosage needed.. If memory serves me right 25mg lead to a smooth +++.. Anyways I am excited how 3-Fluoro-2'-Oxo-PCPr will turn out...
 
so 3-meo-pcpr was around 25mg.... ok, it seems the alkyl-substitute connected to the amine leads to different potency and duration- methoxMetamine needed twice the dosage of MXE. I was thinking, an propyl substituent is going the other way and even enforces the potency. On the phenyl-ring is in position 3 a fluor. This is clearly different from methoxy-groups, fluor is more like an ordinary bound hydrogen with stronger resistance for metabolic oxidation. And even the oxo-group plays an important role i think, it enhances serotonergic effects, while no oxo on the cyclohexane and a methoxy on the phenyl-ring is more responsible for an opioid effect. Removing the halogen (chlor) from ketamine leads to more lucid effects, and even an significant increase in potency. This can be seen on O-PCM. I think with a fluor floxy will be overall between Ketamine and O-PCE within its effects and dosage. Well, this are my thoughts about structure-effect-relationships, i will know more in around an hour :D I will keep you updated

€: i insufflated 5mg...it burns a lot, holy shit :D hydrochlorides are well known for that..... it reminds me of good old 2C-E nose pain oO next time oral is the way to go
 
Synthetic_Night said:
so 3-meo-pcpr was around 25mg.... ok, it seems the alkyl-substitute connected to the amine leads to different potency and duration- methoxMetamine needed twice the dosage of MXE. I was thinking, an propyl substituent is going the other way and even enforces the potency. On the phenyl-ring is in position 3 a fluor. This is clearly different from methoxy-groups, fluor is more like an ordinary bound hydrogen with stronger resistance for metabolic oxidation. And even the oxo-group plays an important role i think, it enhances serotonergic effects, while no oxo on the cyclohexane and a methoxy on the phenyl-ring is more responsible for an opioid effect. Removing the halogen (chlor) from ketamine leads to more lucid effects, and even an significant increase in potency. This can be seen on O-PCM. I think with a fluor floxy will be overall between Ketamine and O-PCE within its effects and dosage. Well, this are my thoughts about structure-effect-relationships, i will know more in around an hour :D I will keep you updated

€: i insufflated 5mg...it burns a lot, holy shit :D hydrochlorides are well known for that..... it reminds me of good old 2C-E nose pain oO next time oral is the way to go
Click to expand...

Interesting! Looking forward hearing back from you again! Have you used other dissos like 3-MeO-PCP or 2-OxO-PCE in order to compare to them? Also, could you please clear your PM inbox, as I wanted to contact you, but your inbox is full? :(
 
Yes, my inbox is full. Only 5 messages in my folder and that's it ^^ but now it is empty.
But i think this substance is not really working for now....maybe a bit like an opioid, but i am not recognizing much....maybe i will test again in 2 days, nothing more will happen today
 
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