Well for people with delayed LTCs there is a greater chance of this stuff. Estrogen isnt a problem until you try treating the T so its not a direct issue.
Testosterone isn't the biggest problem as much as the pregnenolone/progesterone/cortisol stuff. You can afford lower T if your preg/prog/cortisol is better. DHEA-S also plays into this somewhere. In the beginning of my LTC when I was numbed/anxious and in a terrible state I had very low pregnenolone+progesterone. I also had low cortisol.
However, I responded to the ACTH stim test and the endo was like ok no problem but the endo was wrong--the ACTH stim is not a good representation of the real biology. The best test is if your cortisol isn't high under physical/mental stress it shows adrenal insufficiency.
However, it just so happens that the treatments for Testosterone that are not directly replacing T such as HCG or SERMs can help you regenerate preg/prog/cortisol.
Here is a good paper explaining "bioenergetic stress" from MDMA. Bioenergetic stress is essentially "adrenal fatigue" but is a medically accepted term. Adrenal fatigue is real but has just been totally unaccepted cause too many quacks out there have misdefined it as an adrenal problem when it is actually a brain thing.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2826870/
When you push your body too hard it causes this. Doesnt happen in everybody cause their bodies can cope better due to other factors unrelated to mdma such as vitamin/mineral status. If I recall correctly, you also didnt experience a direct LTC and it was delayed and happened cause you suddenly couldnt handle school
That completely falls into this "bioenergetic stress" model.
For others it may have started after a drinking sesh a few weeks later, or an illness. Or even randomly--the random cases aren't "random" but seem that way cause the "stress" is something physical that is unidentified.
And then the symptoms cause mental stress which further pushes you to a total breakdown.
