futura2012
Bluelighter
- Joined
- Apr 28, 2012
- Messages
- 1,371
Been looking into one of my symptoms which is an altered perception of time.
I find since my allergic reaction to BZP I have no concept of time. Days all fade into one. One month seems like a day, half a year seems like a week.
My ability of time recognition since this experience has been shattered.
One theory is memory damage.
Another theory is MDMA can upset the HPA Axis and raise CORTISOL levels.
There is some evidence to suggest this hormone CORTISOL can interfere with your perception of time.
http://www.psychosomaticmedicine.org/content/32/1/39.full.pdf
A possible relationship between variations of hormone levels and changes in time perception is suggested by the work
of several authors. In our laboratory, for example, marked variations in time perception were discovered during various phases of the menstrual cycle.8 Women tended to produce longer time intervals in the premenstrual period, which is a time of progesterone withdrawal." The influences of thyroid hormone on time perception have been described by Stern10-n and Kleber et aV2 A possible relationship between cortisol levels and time estimation is suggested by the similarity in the diurnal changes in both time estimation as reported by Thor13 and cortisol levels as reported by Migeon et al.u
Numerous factors have been shown to affect time perception. These factors include, among others, body temperature12- 19-20 and mental status.21-22'2S Administration of certain drugs, such as barbiturates and amphetamine, in some cases also seems to affect time perception. Interpretation of results seen in drug administration customarily involves the metaphor of an internal clock, whose rate is changed by the drugs in question.
Thus, elevated body temperature19 appears to accelerate the internal clock, while barbiturates24-25 and nitrous oxide26 appear to slow this clock. It is possible that cortisol exerted the effects we observed by mechanisms other than by decelerating the event generating portion of the internal clock. Cortisol could interfere with perception of the
time defining events (whatever they maybe);
Cortisol interferes with a subject's ability to attend selectively to significant stimuli. With selection and filtration impaired, and with his time sense distorted, the subject (or patient) has increasing difficulty with perceptual input. The
high incidence of premorbid pathology in patients who later develop psychoses accompanying the use of corticosteroids37 would support an interaction between perceptual alterations and a weakened ego which defines both the presence or absence as well as the form of symptoms. An extrapolation of any such proposal to account for the psychiatric disturbances observed in patients with Cushing's disease and conditions involving chronic corticosteroid administration should be made with great caution, considering the difference between acute administration and chronic exposure to the drug. For example, chronic states could affect enzyme synthesis that could cause CNS
changes of a different sort from acute administration; also in chronic states CNS compensations could occur.
In general, these results may be described metaphorically as indicating that cortisol slows the rate of an internal clock, or otherwise interferes with the perception of internal timing elements.
I find since my allergic reaction to BZP I have no concept of time. Days all fade into one. One month seems like a day, half a year seems like a week.
My ability of time recognition since this experience has been shattered.
One theory is memory damage.
Another theory is MDMA can upset the HPA Axis and raise CORTISOL levels.
There is some evidence to suggest this hormone CORTISOL can interfere with your perception of time.
http://www.psychosomaticmedicine.org/content/32/1/39.full.pdf
A possible relationship between variations of hormone levels and changes in time perception is suggested by the work
of several authors. In our laboratory, for example, marked variations in time perception were discovered during various phases of the menstrual cycle.8 Women tended to produce longer time intervals in the premenstrual period, which is a time of progesterone withdrawal." The influences of thyroid hormone on time perception have been described by Stern10-n and Kleber et aV2 A possible relationship between cortisol levels and time estimation is suggested by the similarity in the diurnal changes in both time estimation as reported by Thor13 and cortisol levels as reported by Migeon et al.u
Numerous factors have been shown to affect time perception. These factors include, among others, body temperature12- 19-20 and mental status.21-22'2S Administration of certain drugs, such as barbiturates and amphetamine, in some cases also seems to affect time perception. Interpretation of results seen in drug administration customarily involves the metaphor of an internal clock, whose rate is changed by the drugs in question.
Thus, elevated body temperature19 appears to accelerate the internal clock, while barbiturates24-25 and nitrous oxide26 appear to slow this clock. It is possible that cortisol exerted the effects we observed by mechanisms other than by decelerating the event generating portion of the internal clock. Cortisol could interfere with perception of the
time defining events (whatever they maybe);
Cortisol interferes with a subject's ability to attend selectively to significant stimuli. With selection and filtration impaired, and with his time sense distorted, the subject (or patient) has increasing difficulty with perceptual input. The
high incidence of premorbid pathology in patients who later develop psychoses accompanying the use of corticosteroids37 would support an interaction between perceptual alterations and a weakened ego which defines both the presence or absence as well as the form of symptoms. An extrapolation of any such proposal to account for the psychiatric disturbances observed in patients with Cushing's disease and conditions involving chronic corticosteroid administration should be made with great caution, considering the difference between acute administration and chronic exposure to the drug. For example, chronic states could affect enzyme synthesis that could cause CNS
changes of a different sort from acute administration; also in chronic states CNS compensations could occur.
In general, these results may be described metaphorically as indicating that cortisol slows the rate of an internal clock, or otherwise interferes with the perception of internal timing elements.
) Anyways those of us who have experienced this know how bad it can be. I'm not sure if the piperzine i took was bzp or mcpp or something similar but it must have caused the same reaction. My heart wouldnt stop pounding and the dissociation and stuff i was getting was out of this world. Just think of every bad side effect someone can get and add it all together happening at once. The enzyme inhibition makes sense, no wonder it is such a damaging combo. I also think the experience is just so horrendous that it is not only a chemical reaction that is damaging us from that night, it is the trauma that sticks with us. It is just too much stress at once to be tripping out on a pipe and not knowing if you will make it to see tomorrow. Best thing to do is not get so caught up in it, whats done is done. Focus on getting better, only thing we can do : (