This quote pretty much sums up how most BL users feel about those asking for help, even after they are pretty fucked up.
I don't particularly care about this one thread or what TeOX2t said....but it is a damned good quote to illustrate the mentality of young drug users.
Keep chuckling.
Xanax increases GABA in the brain, which suppresses glutamate.
Glutamate is the brain's primary excitatory neurotransmitter and is involved in cellular toxicity if levels get high enough.
It literally destroys connects between neurons or neurons themselves.
Since our understanding of the brain is only beginning, it is possible that such a process is a tool used by the brain for a beneficial purpose.
Like re-wiring damaged circuits or limiting the activity of certain brain regions.
This may be important to the glutamate theory of schizophrenia.
But when drugs cause toxicity, glutamate is probably NOT serving any positive role.
And with MDMA, glutamate may be part of the toxic cascade that leads to serotonin axotomy.
I believe that in MDMA users that go on to develop anxiety problems, glutamate and cortisol both remain high for MONTHS.
And continue to cause cell death for some time.
And perhaps some of this is necessary for 'recovery'.
Especially since glutamate kills hypothalamus neurons, which is the relay station for serotonin nerves extending towards the frontal lobes!
Some research suggests that after glutamate-induced cell death, some hypothalamic neurons can regrow.
This is unique, because only a few regions of the brain are known to experience STEM cell proliferation and neuron growth.
After injury, some parts of the brain are actually capable of this.
Exciting stuff.
But during MDMA use, glutamate may contribute to hypothalmic damage.
Even if it doesn't, the hypothalamus is the site of MDMAs euphoric effects and eventual damage.
The hypothalamus causes the endocrine system to release the powerful prolactin/oxytocin combo that combine with dopamine to produce the incredible effects of the drug. This is AFTER the hypothalamus tells the adrenals to release MASSIVE waves of cortisol which lower brain serotonin!
And during abstinence, esp. with high or repeated doses of MDMA, the hypothalamus is seen to be hyper-innervated by serotonin...leaving the frontal lobes and PFC with sub-standard density.
Damn.
So, YES - taking xanax and MDMA together probably offers real neuroprotection.
Those experiencing acute reactions like Serotonin Syndrome are normally given a benzo in the ER.
It prevents skeletal muscle destruction, hyperthermia, and stroke!
This endorsement does not mean that the primary neurotoxic effects of MDMA can be blocked by benzos.
It is notable that many people go home from the ER and continue to experience the 're-wiring' of the brain, despite administration which prevents catastrophic consequences. The degeneration of serotonin neurons happens due to nasty metabolites of MDMA and dopamine.
But glutamate may increase the presence of these nasty metabolites.
And as a secondary toxicity it can kill neurons all on its own.
So benzos + MDMA is one combo that I approve.
Still gonna say my standard warning - NO redosing on MDMA.
Or you will only have more of this to come back to...
combining an SSRI with something like DXM, that is dangerous and can cause SS, so before you take any drug, first research possible interactions
