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LSD Synthesis

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genaro, it's actually not possible. Or if it is, no one has done it and recorded their work.

LSAs will have similar but definitely different effects than LSD at an equipotent dose, however. If you were good, you could extract it from HBWR or MG seeds and obtains crystals of a different, but very nice, drug.
 
It is indeed possible, just not worthwhile. There was a good bit of info at the hive about it using PyBOP.

Why it's possible: After hydrolysis with KOH, you've got lysergic acid, a major step in most synths, including shulgin's, though he used ET to start.

Why it isn't worthwhile: Purifying LSA from seed source isn't an easy task. Ergolines tend to be a goop if they aren't extremely pure. And obviously, you'd need a shitload of starting material.
 
psych@delic said:
the United tates only need about a pound of LSD-25 a year to satiate all its users. with this in mind, think of how little it must be produced. most of the LSD that is made is mad eby a few skilled chemists. It is VERY difficult to synthesize, in fact a 20% yield ina batch is a great success. the reasons for this is because it degrades rapidly, almost too rapidly. light, heat, moisture, oxygen , and time all destroy it. if u do it right ull prolly trip while making it too. but if u reallytwanna do it, as do i. u can go get some ergo, and build a devise to produce it in a large3 scale. i forget where but i hav the blue prints to doit. with a simple ergot alkaloid extraction u hav some freakly shit. dont touch it as it causes gangreen and keep it in freebase so it dosnt destroy itself, after that step comes the haard part, the actual reduction/conversion into LSD-25. b prepared to drop maybe a thousand bucks and a shit load of effort to make the shiite. i would personally just use the LSA from the alkaloids to trip, but what do i kno. BTW jus some fun info, the salem witch trials ovccurred in the same time as many of the crops in the area became contaminated with ergot, producing the witches visions. but if u wanna make the LSD-25, go for it, the worst that will happen is ul wasate ur money but get a nice lab outta it. i doubtr ull b ableto do it. it would b easier to synthesize dimethyltryptamine.... jus get some hawwaiin baby wwoodrose seeds and grow a plant, thats allthe lysergamide ull need in ur life.

I thought much of the salem witch trials had to do with datura and hellsbells. The women knew the garden much better than the men and this is a reason why women wer convited more often then males(of course there were still other reasons). The women knew of hells bells and it's effects. They would brew it and rub the brew on broomsticks. These women were called witches cause they had "contacted the devil" and had the ability to "fly" on the broomstick, all thing linking to the psychedelic properties of hellsbells.
 
com4tblynumb said:
I thought much of the salem witch trials had to do with datura and hellsbells. The women knew the garden much better than the men and this is a reason why women wer convited more often then males(of course there were still other reasons). The women knew of hells bells and it's effects. They would brew it and rub the brew on broomsticks. These women were called witches cause they had "contacted the devil" and had the ability to "fly" on the broomstick, all thing linking to the psychedelic properties of hellsbells.

Actually, you're correct. I did a speech on the tropane alkaloids' role in the witch trials in college :)

But, I believe the "hellsbells" you're referring to is henbane. Either that or its a nickname I've never heard.
 
Piglet said:
Ergotamine is NOT the best start material. Cabergoline is commercially available and leads to a legal & stronger analogue.

Er, it is - well either ergotamine or ergonovine. Cabergoline on hydrolysis of the amide group gives N-(6)-allylnorlysergic acid, which ends up, upon formation of the N,N-diethylamide as AL-LAD (TIHKAL #1) which isn't as active as LSD; only the N-ethyl nor-LSD was marginally more active than LSD (although it is uncontrolled in all the countries I've checked)


Piglet said:
I also invite interested parties to consider other amides & substitution of the 8 nitrogen.

Apart from the amide formed using 1,3-dimethylaziridine, none of the other amides comes anywhere near the potency of the N,N-diethylamide. Oh and 8-nitrogen? * is where the carboxamide function is attached - the nitrogen is at pos 6.


Piglet said:
Using modern methods, I can reassure people that a 2 step route with over 50% yield is available. You don't need toxic OR controlled chemicals.

Again, eh? Ergotamine and the other ergot alkaloids that can be used as a source of lysergic acid are about the most monitored drug precursors going.


Piglet said:
Nobody EVER grew ergotamine to make LSD! It's total BS from a 4th rate chemist.

You don't grow ergotamine full stop. You grow ergot (C. purpurea), then extract the ergotamine (and other alkaloids like ergonovine) from the sclera (ergot fruiting bodies). As to nobody ever grew it to make LSD, where does all the ergotamine tartrate come from? The original Hoffman synth used ergotamine from ergot as a total synthesis of lysergic acid didn't occur until years later.


As far as I'm aware, you can use HBWR as a source of lysergic acid as the majority of the alkaloids contained in HBWR are N-substituted lysergamide derivitives, which can be hydrolysed to lysergic acid (final product being lysergic acid monohydrate) in the same way that ergotamine is. As for separation of the alkaloids from the rest of the crap contained in the seeds, that can be achieved fairly easily using ion-exchange resin chromatography (the best one for alkaloidal purification IMO being Amberlite IRC-50 - which is cheap & easily obtained ). Admittedly it involves a shit-load of HBWR seeds and extraction equipment that would look more in place in a vinyard grape pressing facility, but it's not a pie-in-the-sky method!
 
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J. Alfred Prufrock said:
According to this document, one could conclude it would be more difficult to obtain lysergic acid (or LSA) from a natural source than the actual manufacture of LSD.

One irony here is Piglet was right in his comments above. Hardison used PyBOP

Read the PDF appeal; document and on strictly legal grounds, Hardison def. seems to have a case because of the Crown witholding evidence pertinant to his defence. Unfortunately, with regard to the 'illegal search' he alludes to, he is basing his defence on a arguement that would work in the US courts, but in the UK the officers are entitled to enter a premesis if they believe an arrestable offence has/is being committed (ie an offence carrying a max penalty of over 5 years in prison). The materials found more than 2 days after the execution of the Search Warrant (from an unsecured scene) may well be on dodgy ground, but I'd imagine something like that is the sort of thing that barristers could argue over until the cows come home.

Whatever the outcome of the appeal (I don't think he'll get his conviction quoshed), his sentance should def be reviewed & downgraded because of the breaches in the defence notification proceedures that the Crown were blatent in committing.

Then again, law isn't my area of specialist knowledge (biochem/pharmacology is) so all the above might just be so much manure!
 
its amazing that such a complex-to-synth chemical was created by accident.
i have read of people on a certain psilo-supportive website that you can 'feel' the vial of acid in your pocket. The very presence of LSD does indeed have an effect, if not any
 
Damn this thread inspires me to continue my BS majoring in chem haha
 
This PDF, Practical LSD Manufacture by Uncle Fester, gives some great info on the intricacies of all aspects of LSD production. It'll probably be a while before you can obtain all the supplies to make your plan (or currently lack thereof) a reality, but if you're truly devoted to the idea it isn't outside of the realm of possibility, it'll just take a fair amount of time, money, and especially devotion.
 
This thread's interesting reading, but until a there's a method using precursors that aren't closely watched, i'll leave the acid production to the professionals.
 
^This thread is dangerous reading, TBH.

There's lots of misinformation being thrown around in here.

Honestly, its kind of ridiculous that we even have a thread titled "LSD synthesis" in PD-- granted the thread is pretty ancient.
 
^This thread is dangerous reading, TBH.

There's lots of misinformation being thrown around in here.

Honestly, its kind of ridiculous that we even have a thread titled "LSD synthesis" in PD-- granted the thread is pretty ancient.

On a forum on which synthesis discussion is prohibited.
 
Does anybody know if LSD synthesis is performed in university chemistry courses anymore?

I know that in the past it was often covered due to it being a complex synthesis with a lot practical knowledge to gain from.
 
Does anybody know if LSD synthesis is performed in university chemistry courses anymore?

I know that in the past it was often covered due to it being a complex synthesis with a lot practical knowledge to gain from.

From what I've heard about some universities, the LSD produced must be destroyed after synthesis. Also, I guess people choosing a project like this are on a watched list after.
 
^ Thanks for information and that seems logical.

I remember though my aunty who did a chemistry degree probably around 20 years ago was allowed to keep what she produced. Apparently the professors used it as a method of being popular and "cool and hip"

It is also a god damn easy way to get students enthusiastic about their practical work :D
 
Does anybody know if LSD synthesis is performed in university chemistry courses anymore?

I know that in the past it was often covered due to it being a complex synthesis with a lot practical knowledge to gain from.

You're asking if undergraduate students are taught to make LSD? 8)

This would never be allowed in any country where LSD is illegal (which happens to be many countries). There is no practical knowledge to be gained that couldn't be acquired making other legally possessed/produced molecules instead.

The synthesis of LSD from ET is not complex, however LSD is a relatively complex molecule. LSD is difficult to make because it requires precursors with relatively complex, very specific molecular structures which are easily watched/controlled. The actual synthesis (when you have the right precursors) is pretty simple. Someone with a Master's or Ph.D. in organic chemistry could do it without much trouble.

When I was in graduate school, I taught a practical course at a Uni where my students made Modafinil (available by prescription). At the end of the lab I had to go around and collect everyone's samples. They were definitely not allowed to keep the products.;)
 
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